Search Results - "Brooks, Rebekah"

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR by Walton, Zandra E., Patel, Chirag H., Brooks, Rebekah C., Yu, Yongjun, Ibrahim-Hashim, Arig, Riddle, Malini, Porcu, Alessandra, Jiang, Tianying, Ecker, Brett L., Tameire, Feven, Koumenis, Constantinos, Weeraratna, Ashani T., Welsh, David K., Gillies, Robert, Alwine, James C., Zhang, Lin, Powell, Jonathan D., Dang, Chi V.

“…Recent reports indicate that hypoxia influences the circadian clock through the transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes…”
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Autophagy: clocking in for the night shift by Brooks, Rebekah C, Dang, Chi V

“…Daily rhythms of biological activity, such as cycles of sleep–wake and feeding–fasting, are coupled to cell‐autonomous circadian clocks to synchronize…”
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mTOR Senses Intracellular pH through Lysosome Dispersion from RHEB by Walton, Zandra E., Brooks, Rebekah C., Dang, Chi V.

“…Acidity, generated in hypoxia or hypermetabolic states, perturbs homeostasis and is a feature of solid tumors. That acid peripherally disperses lysosomes is a…”
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ACLY alternative splicing correlates with cancer phenotypes by Supplee, Julianna G., Affronti, Hayley C., Duan, Richard, Brooks, Rebekah C., Stine, Zachary E., Nguyen, Phuong T.T., Pinheiro, Laura V., Noji, Michael C., Drummond, Jack M., Huang, Kevin, Schultz, Kollin, Dang, Chi V., Marmorstein, Ronen, Wellen, Kathryn E.

“…ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism and provides nucleocytosolic acetyl-CoA for protein acetylation. ACLY has two major splice…”
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Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity by Zhang, Xue, Pant, Shishir M., Ritch, Cecily C., Tang, Hsin-Yao, Shao, Hongguang, Dweep, Harsh, Gong, Yao-Yu, Brooks, Rebekah, Brafford, Patricia, Wolpaw, Adam J., Lee, Yool, Weeraratna, Ashani, Sehgal, Amita, Herlyn, Meenhard, Kossenkov, Andrew, Speicher, David, Sorger, Peter K., Santagata, Sandro, Dang, Chi V.

“…The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role…”
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Strategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from Plasmodium Infection in a Murine Model by Reeder, Sophia M, Bah, Mamadou A, Tursi, Nicholas J, Brooks, Rebekah C, Patel, Ami, Esquivel, Rianne, Eaton, Alison, Jhun, Hugo, Chu, Jacqueline, Kim, Kevin, Xu, Ziyang, Zavala, Fidel, Weiner, David B

“…Malaria infects millions of people every year, and despite recent advances in controlling disease spread, such as vaccination, it remains a global health…”
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MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis by Cazarin, Juliana, DeRollo, Rachel E, Shahidan, Siti Noor Ain Binti Ahmad, Burchett, Jamison B, Mwangi, Daniel, Krishnaiah, Saikumari, Hsieh, Annie L, Walton, Zandra E, Brooks, Rebekah, Mello, Stephano S, Weljie, Aalim M, Dang, Chi V, Altman, Brian J

“…The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many…”
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Leveraging mHealth and Virtual Reality to Improve Cognition for Alzheimer’s Patients: A Systematic Review by Kruse, Clemens Scott, Sen, Keya, Armenta, Valery, Hubbard, Nicole, Brooks, Rebekah

“…Background: Alzheimer’s Disease (AD) is a global problem affecting 58 million people, expected to reach a prevalence of 88 million people by 2050. The disease…”
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Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism by Hsieh, Annie L., Zheng, Xiangzhong, Yue, Zhifeng, Stine, Zachary E., Mancuso, Anthony, Rhoades, Seth D., Brooks, Rebekah, Weljie, Aalim M., Eisenman, Robert N., Sehgal, Amita, Dang, Chi V.

“…Drosophila Myc (dMyc) is highly conserved and functions as a transcription factor similar to mammalian Myc. We previously found that oncogenic Myc disrupts the…”
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Circadian Clock's Cancer Connections by Walton, Zandra E, Altman, Brian J, Brooks, Rebekah C, Dang, Chi V

“…The circadian molecular clock regulates and coordinates cellular metabolism with the organism's daily feeding and fasting cycle. Disruption of circadian…”
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Adverse Events Associated With Deep Brain Stimulation for Movement Disorders: Analysis of 510 Consecutive Cases by Patel, Daxa M, Walker, Harrison C, Brooks, Rebekah, Omar, Nidal, Ditty, Benjamin, Guthrie, Barton L

“…BACKGROUND:Although numerous studies have focused on the efficacy of deep brain stimulation (DBS) for movement disorders, less is known about surgical adverse…”
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Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis by Brooks, Rebekah, Monzy, Judith, Aaron, Bailey, Zhang, Xue, Kossenkov, Andrew, Hayden, James, Keeney, Frederick, Speicher, David W., Zhang, Lin, Dang, Chi V.

“…We identify ADIRF-AS1 circadian long non-coding RNA (lncRNA). Deletion of ADIRF-AS1 in U2OS cells alters rhythmicity of clock-controlled genes and expression…”
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The effect of spinal introducer needle use on postoperative back pain by Brooks, Rebekah R, Oudekerk, Chris, Olson, R Lee, Daniel, Carol, Vacchiano, Charles, Maye, John

“…Postdural puncture back pain has a reported incidence ranging from 2% to 29% following the administration of a spinal anesthetic. The purpose of this…”
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Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle by Lee, Yool, Fong, Shi Yi, Shon, Joy, Zhang, Shirley L, Brooks, Rebekah, Lahens, Nicholas F, Chen, Dechun, Dang, Chi Van, Field, Jeffrey M, Sehgal, Amita

“…Circadian rhythms are an integral part of physiology, underscoring their relevance for the treatment of disease. We conducted cell-based high-throughput…”
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Abstract 3711: Molecular and cancer-related roles of ATP-citrate lyase exon 14 by Supplee, Julianna G., Affronti, Hayley C., Duan, Richard, Brooks, Rebekah C., Nguyen, Phuong, Schultz, Kollin, Marmorstein, Ronen, Wellen, Kathryn E.

“…Abstract Introduction: ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism as well as provides acetyl-CoA necessary for histone acetylation,…”
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PBAF-Associated Circadian lncRNA ADIRF-AS1 Regulates Renal Clear Cell Tumorigenesis by Brooks, Rebekah Christianna

“…The roles of lncRNAs, particularly those regulated by the circadian transcription factors BMAL1-CLOCK, in biological processes are poorly understood. We…”
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Acute fatty liver of pregnancy: a case report by Brooks, Rebekah R, Feller, Cynthia M, Maye, John P

“…The third trimester of pregnancy has several unique disease entities that challenge the anesthetist. Acute fatty liver of pregnancy (AFLP) is an increasingly…”
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Distribution and concentration of metals in sediments and water of the Clark Fork River floodplain, Montana by Brooks, Rebekah

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Sediment-Water Interactions in the Metal-Contaminated Floodplain of the Clark Fork River, Montana, USA by Brooks, Rebekah, Moore, Johnnie N.

“…The distribution and concentration of metals and metalloids in the floodplain of the Clark Fork River of western Montana, USA, are mainly controlled by…”
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