Search Results - "Brooks, Keith J"

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats by Nagel, Simon, Papadakis, Michalis, Chen, Ruoli, Hoyte, Lisa C, Brooks, Keith J, Gallichan, Daniel, Sibson, Nicola R, Pugh, Chris, Buchan, Alastair M

“…Dimethyloxalylglycine (DMOG) is an inhibitor of prolyl-4-hydroxylase domain (PHD) enzymes that regulate the stability of hypoxia-inducible factor (HIF). We…”
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Cellular and molecular determinants of stroke-induced changes in subventricular zone cell migration by Young, Christopher C, Brooks, Keith J, Buchan, Alastair M, Szele, Francis G

“…A remarkable aspect of adult neurogenesis is that the tight regulation of subventricular zone (SVZ) neuroblast migration is altered after ischemic stroke and…”
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Blocked angiogenesis in Galectin-3 null mice does not alter cellular and behavioral recovery after middle cerebral artery occlusion stroke by Young, Christopher C, Al-Dalahmah, Osama, Lewis, Nicola J, Brooks, Keith J, Jenkins, Micaela M, Poirier, Françoise, Buchan, Alastair M, Szele, Francis G

“…Abstract Angiogenesis is thought to decrease stroke size and improve behavioral outcomes and therefore several clinical trials are seeking to augment it…”
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Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke by Young, Christopher C, van der Harg, Judith M, Lewis, Nicola J, Brooks, Keith J, Buchan, Alastair M, Szele, Francis G

“…Subventricular zone (SVZ) astrocytes and ependymal cells are both derived from radial glia and may have similar gliotic reactions after stroke. Diminishing SVZ…”
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MRI detects early hindlimb muscle atrophy in Gly93Ala superoxide dismutase-1 (G93A SOD1) transgenic mice, an animal model of familial amyotrophic lateral sclerosis by Brooks, Keith J., Hill, Mark D. W., Hockings, Paul D., Reid, David G.

“…MRI has been used to measure hindlimb muscle volume in female and male transgenic mice overexpressing the Gly93Ala (G93A) mutant human superoxide dismutase 1…”
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Molecular magnetic resonance imaging of acute vascular cell adhesion molecule-1 expression in a mouse model of cerebral ischemia by Hoyte, Lisa C, Brooks, Keith J, Nagel, Simon, Akhtar, Asim, Chen, Ruoli, Mardiguian, Sylvie, McAteer, Martina A, Anthony, Daniel C, Choudhury, Robin P, Buchan, Alastair M, Sibson, Nicola R

“…The pathogenesis of stroke is multifactorial, and inflammation is thought to have a critical function in lesion progression at early time points. Detection of…”
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Acute and repeated dose (28 day) mouse oral toxicology studies with Cry34Ab1 and Cry35Ab1 Bt proteins used in coleopteran resistant DAS-59122-7 corn by Juberg, Daland R., Herman, Rod A., Thomas, Johnson, Brooks, Keith J., Delaney, Bryan

“…Expression of the Cry34Ab1 and Cry35Ab1 proteins from Bacillus thuringiensis (Bt) Berliner strain PS149B1 in genetically modified maize (event DAS-59122-7)…”
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Protection of Respiratory Chain Enzymes from Ischaemic Damage in Adult Rat Brain Slices by Brooks, Keith J., Hargreaves, Iain P., Bates, Timothy E.

“…The effect of aglycaemic hypoxia (AH) on the activity of the mitochondrial respiratory chain complexes was measured in superfused adult cortical brain slices…”
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Automatic Quantification of Changes in Bone in Serial MR Images of Joints by Leung, K.K., Holden, M., Saeed, N., Brooks, K.J., Buckton, J.B., Williams, A.A., Campbell, S.P., Changani, K., Reid, D.G., Yong Zhao, Wilde, M., Rueckert, D., Hajnal, J.V., Hill, D.L.G.

“…Recent innovations in drug therapies have made it highly desirable to obtain sensitive biomarkers of disease progression that can be used to quantify the…”
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MRI quantification in vivo of corticosteroid induced thymus involution in mice: Correlation with ex vivo measurements by Brooks, Keith J., Bunce, Keith T., Haase, Michael V., White, Alan, Kumar Changani, K., Bate, Simon T., Reid, David G.

“…Thymus involution is a useful marker of transactivation-mediated side effects in preclinical therapeutic index testing of new anti-inflammatory…”
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Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia by BROOKS, Keith J, HARGREAVES, Iain, ORDIDGE, Roger, NGUYEN, Quyen, CLEMENCE, Matthew, WYATT, John, BATES, Timothy E, BHAKOO, Kishore, SELLWOOD, Mark, O'BRIEN, Francis, NOONE, Martina, SAKATA, Yasuko, CADY, Ernest, WYLEZINSKA, Marzena, THORNTON, John

“…The effects of normothermia and delayed hypothermia on the levels of N-acetylaspartate (NAA), reduced glutathione (GSH) and the activities of mitochondrial…”
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Nitric-oxide-induced inhibition of mitochondrial complexes following aglycaemic hypoxia in neonatal cortical rat brain slices by Brooks, K J, Hargreaves, I P, Bates, T E

“…The effect of aglycaemic hypoxia (AH) on the activity of the mitochondrial respiratory chain complexes was measured in superfused neonatal cortical brain…”
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Time-dependent impairment of mitochondrial function after storage and transplantation of rabbit kidneys by SAMMUT, I. A, BURTON, K, BALOGUN, E, SARATHCHANDRA, P, BROOKS, K. J, BATES, T. E, GREEN, C. J

“…The mitochondrial respiratory chain is implicated as a major target of kidney damage after ischemia-reperfusion. This study measures changes in integrated…”
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TIME-DEPENDENT IMPAIRMENT OF MITOCHONDRIAL FUNCTION AFTER STORAGE AND TRANSPLANTATION OF RABBIT KIDNEYS1 by Sammut, Ivan A., Burton, Kate, Balogun, Elizabeth, Sarathchandra, Padmini, Brooks, Keith J., Bates, Timothy E., Green, Colin J.

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Assessment of energy metabolism in the developing brain following aglycemic hypoxia by1H and31P NMR by Brooks, Keith J., Clark, John B., Bates, Timothy E.

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Calcium-mediated damage following hypoxia in cerebral cortex ex vivo studied by NMR spectroscopy. Evidence for direct involvement of voltage-gated Ca(2+)-channels by Brooks, K J, Kauppinen, R A

“…Calcium plays a prominent role in the neuronal degeneration which accompanies stroke and there has been much conjecture about the possible source of this Ca2+…”
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3‐Hydroxybutyrate Aids the Recovery of the Energy State from Aglycaemic Hypoxia of Adult but Not Neonatal Rat Brain Slices by Brooks, Keith J., Clark, John B., Bates, Timothy E.

“…: The level of phosphocreatine (PCr) and the intracellular pH (pHi) of superfused cortical brain slices from adult or 10‐day‐old rats were monitored using 31P…”
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The regulation of intracellular pH studied by 31P- and 1H-NMR spectroscopy in superfused guinea-pig cerebral cortex slices by Brooks, K J, Bachelard, H S

“…(1) The intracellular pH (pHi) of superfused slices of guinea-pig cerebral cortex was measured in 31P-NMR spectra using the chemical shifts of intracellular…”
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Relationship between stimulated inositol lipid hydrolysis and contractility in guinea-pig visceral longitudinal smooth muscle by Best, L, Brooks, K J, Bolton, T B

“…Carbamylcholine caused a marked, concentration-dependent stimulation of [3H]Ins P, [3H] InsP2 and to a lesser extent [3H]InsP3 production in guinea-pig…”
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Effects of hypoglycaemia and hypoxia on the intracellular pH of cerebral tissue as measured by 31P nuclear magnetic resonance by Brooks, K J, Porteous, R, Bachelard, H S

“…Changes in high-energy phosphate metabolites and the intracellular pH (pHi) were monitored in cerebral tissue during periods of hypoglycaemia and hypoxia using…”
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