Search Results - "Brooks, Douglas A."

A Molecular Probe for the Detection of Polar Lipids in Live Cells by Bader, Christie A, Shandala, Tetyana, Carter, Elizabeth A, Ivask, Angela, Guinan, Taryn, Hickey, Shane M, Werrett, Melissa V, Wright, Phillip J, Simpson, Peter V, Stagni, Stefano, Voelcker, Nicolas H, Lay, Peter A, Massi, Massimiliano, Plush, Sally E, Brooks, Douglas A

“…Lipids have an important role in many aspects of cell biology, including membrane architecture/compartment formation, intracellular traffic, signalling,…”
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Fluorescence Microscopy-An Outline of Hardware, Biological Handling, and Fluorophore Considerations by Hickey, Shane M, Ung, Ben, Bader, Christie, Brooks, Robert, Lazniewska, Joanna, Johnson, Ian R D, Sorvina, Alexandra, Logan, Jessica, Martini, Carmela, Moore, Courtney R, Karageorgos, Litsa, Sweetman, Martin J, Brooks, Douglas A

“…Fluorescence microscopy has become a critical tool for researchers to understand biological processes at the cellular level. Micrographs from fixed and…”
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Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression by Lazniewska, Joanna, Li, Ka Lok, Johnson, Ian R. D., Sorvina, Alexandra, Logan, Jessica M., Martini, Carmela, Moore, Courtney, Ung, Ben S.-Y., Karageorgos, Litsa, Hickey, Shane M., Prabhakaran, Sarita, Heatlie, Jessica K., Brooks, Robert D., Huzzell, Chelsea, Warnock, Nicholas I., Ward, Mark P., Mohammed, Bashir, Tewari, Prerna, Martin, Cara, O’Toole, Sharon, Edgerton, Laura Bogue, Bates, Mark, Moretti, Paul, Pitson, Stuart M., Selemidis, Stavros, Butler, Lisa M., O’Leary, John J., Brooks, Douglas A.

“…Prostate cancer (PCa) development and progression relies on the programming of glucose and lipid metabolism, and this involves alterations in androgen receptor…”
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Altered endosomal-lysosomal biogenesis in melanoma by Lam, Giang T, Sorvina, Alexandra, Martini, Carmela, Prabhakaran, Sarita, Ung, Ben S-Y, Lazniewska, Joanna, Moore, Courtney R, Beck, Andrew R, Hopkins, Ashley M, Johnson, Ian R D, Caruso, Maria C, Hickey, Shane M, Brooks, Robert D, Jackett, Louise, Karageorgos, Litsa, Foster-Smith, Erwin J, Malone, Victoria, Klebe, Sonja, O'Leary, John J, Brooks, Douglas A, Logan, Jessica M

“…Cutaneous melanoma is the deadliest form of skin neoplasm and its high mortality rates could be averted by early accurate detection. While the detection of…”
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Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion by Armstrong, Heather K., Gillis, Joanna L., Johnson, Ian R. D., Nassar, Zeyad D., Moldovan, Max, Levrier, Claire, Sadowski, Martin C., Chin, Mei Yieng, Tomlinson Guns, Emma S., Tarulli, Gerard, Lynn, David J., Brooks, Douglas A., Selth, Luke A., Centenera, Margaret M., Butler, Lisa M.

“…The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple…”
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Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers by Logan, Jessica M., Martini, Carmela, Sorvina, Alexandra, Johnson, Ian R. D., Brooks, Robert D., Caruso, Maria C., Huzzell, Chelsea, Moore, Courtney R., Karageorgos, Litsa, Butler, Lisa M., Tewari, Prerna, Prabhakaran, Sarita, Hickey, Shane M., Klebe, Sonja, Samaratunga, Hemamali, Delahunt, Brett, Moretti, Kim, O’Leary, John J., Brooks, Douglas A., Ung, Ben S.-Y.

“…The diagnosis of prostate cancer using histopathology is reliant on the accurate interpretation of prostate tissue sections. Current standards rely on the…”
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CDKI-73 is a Novel Pharmacological Inhibitor of Rab11 Cargo Delivery and Innate Immune Secretion by Sorvina, Alexandra, Shandala, Tetyana, Wang, Shudong, Sharkey, David J, Parkinson-Lawrence, Emma, Selemidis, Stavros, Brooks, Douglas A

“…Innate immunity is critical for host defence against pathogen and environmental challenge and this involves the production and secretion of immune mediators,…”
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Newborn screening for lysosomal storage disorders by Meikle, Peter J., Grasby, Dallas J., Dean, Caroline J., Lang, Debbie L., Bockmann, Michelle, Whittle, Alison M., Fietz, Michael J., Simonsen, Henrik, Fuller, Maria, Brooks, Douglas A., Hopwood, John J.

“…Lysosomal storage disorders (LSD) are chronic progressive diseases that have a devastating impact on the patient and family. Most patients are clinically…”
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Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo by Sorvina, Alexandra, Shandala, Tetyana, Brooks, Douglas A

“…The secretion of immune-mediators is a critical step in the host innate immune response to pathogen invasion, and Rab GTPases have an important role in the…”
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Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy by Kelly, Tanya E, Spillane, Cathy L, Ward, Mark P, Hokamp, Karsten, Huang, Yanmei, Tewari, Prerna, Martin, Cara M, Norris, Lucy A, Mohamed, Bashir M, Bates, Mark, Brooks, Robert, Selemidis, Stavros, Brooks, Douglas A, Kamran, Waseem, Saadeh, Feras Abu, O'Toole, Sharon A, O'Leary, John J

“…High-grade serous ovarian cancer (HGSOC) is the most prevalent and deadliest subtype of epithelial ovarian cancer (EOC), killing over 140,000 people annually…”
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Spectroscopic and Molecular Docking Study of the Interaction between Neutral Re(I) Tetrazolate Complexes and Bovine Serum Albumin by Lazniewska, Joanna, Agostino, Mark, Hickey, Shane M., Parkinson‐Lawrence, Emma, Stagni, Stefano, Massi, Massimiliano, Brooks, Douglas A., Plush, Sally E.

“…Re(I) complexes have potential in biomedical sciences as imaging agents, diagnostics and therapeutics. Thus, it is crucial to understand how Re(I) complexes…”
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Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells by Caporale, Chiara, Bader, Christie A., Sorvina, Alexandra, MaGee, Karen D. M., Skelton, Brian W., Gillam, Todd A., Wright, Phillip J., Raiteri, Paolo, Stagni, Stefano, Morrison, Janna L., Plush, Sally E., Brooks, Douglas A., Massi, Massimiliano

“…A family of five neutral cyclometalated iridium(III) tetrazolato complexes and their methylated cationic analogues have been synthesised and characterised. The…”
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A Drosophila model to image phagosome maturation by Shandala, Tetyana, Lim, Chiaoxin, Sorvina, Alexandra, Brooks, Douglas A

“…Phagocytosis involves the internalization of extracellular material by invagination of the plasma membrane to form intracellular vesicles called phagosomes,…”
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A 3,4-dimethoxy-1,8-naphthalimide for lipid droplet imaging in live and fixed cells by Johnson, Ian R.D., Rudebeck, Elley E., Sweetman, Martin J., Sorvina, Alexandra, Ashton, Trent D., Pfeffer, Frederick M., Brooks, Douglas A., Hickey, Shane M.

“…Lipid droplets (LDs) are found in most eukaryotic cells and in addition to serving as lipid reservoirs, these highly dynamic organelles play fundamental roles…”
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Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression by Nturubika, Bukuru D., Guardia, Carlos M., Gershlick, David C., Logan, Jessica M., Martini, Carmela, Heatlie, Jessica K., Lazniewska, Joanna, Moore, Courtney, Lam, Giang T., Li, Ka L., Ung, Ben S-Y, Brooks, Robert D., Hickey, Shane M., Bert, Andrew G., Gregory, Philip A., Butler, Lisa M., O’Leary, John J., Brooks, Douglas A., Johnson, Ian R. D.

“…Background This study focuses on the role of lysosomal trafficking in prostate cancer, given the essential role of lysosomes in cellular homoeostasis. Methods…”
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Cross-Coupling of Amide and Amide Derivatives to Umbelliferone Nonaflates: Synthesis of Coumarin Derivatives and Fluorescent Materials by Hickey, Shane M, Nitschke, Samuel O, Sweetman, Martin J, Sumby, Christopher J, Brooks, Douglas A, Plush, Sally E, Ashton, Trent D

“…The Buchwald-Hartwig cross-coupling reaction between 4-methylumbelliferone-derived nonaflates with amides, carbamates, and sulfonamides is described. A wide…”
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Distinct patterns of biomarker expression for atypical intraductal proliferations in prostate cancer by Martini, Carmela, Logan, Jessica M., Sorvina, Alexandra, Prabhakaran, Sarita, Ung, Benjamin S Y., Johnson, Ian R. D., Hickey, Shane M., Brooks, Robert D., Caruso, Maria C., Klebe, Sonja, Karageorgos, Litsa, O’Leary, John J., Delahunt, Brett, Samaratunga, Hemamali, Brooks, Douglas A

“…High-grade prostatic intraepithelial neoplasia (HGPIN) is a well-characterised precursor lesion in prostate cancer. The term atypical intraductal…”
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Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome system by Tang, Jingying, Lam, Giang T., Brooks, Robert D., Miles, Mark, Useckaite, Zivile, Johnson, Ian RD, Ung, Ben S.-Y., Martini, Carmela, Karageorgos, Litsa, Hickey, Shane M., Selemidis, Stavros, Hopkins, Ashley M., Rowland, Andrew, Vather, Ryash, O'Leary, John J., Brooks, Douglas A., Caruso, Maria C., Logan, Jessica M.

“…The highly heterogenous nature of colorectal cancer can significantly hinder its early and accurate diagnosis, eventually contributing to high mortality rates…”
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Publisher Correction to: Distinct patterns of biomarker expression for atypical intraductal proliferations in prostate cancer by Martini, Carmela, Logan, Jessica M, Sorvina, Alexandra, Prabhakaran, Sarita, Ung, Benjamin S-Y, Johnson, Ian R D, Hickey, Shane M, Brooks, Robert D, Caruso, Maria C, Klebe, Sonja, Karageorgos, Litsa, O'Leary, John J, Delahunt, Brett, Samaratunga, Hemamali, Brooks, Douglas A

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Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time by Bader, Christie A., Sorvina, Alexandra, Simpson, Peter V., Wright, Phillip J., Stagni, Stefano, Plush, Sally E., Massi, Massimiliano, Brooks, Douglas A.

“…Live cell imaging can provide important information on cellular dynamics; however, the full utilisation of this technology has been hampered by the limitations…”
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