Search Results - "Brooks, David J."

An early and late peak in microglial activation in Alzheimer's disease trajectory by Fan, Zhen, Brooks, David J, Okello, Aren, Edison, Paul

“…Amyloid-β deposition, neuroinflammation and tau tangle formation all play a significant role in Alzheimer's disease. We hypothesized that there is microglial…”
Get full text

Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study by Horsager, Jacob, Andersen, Katrine B, Knudsen, Karoline, Skjærbæk, Casper, Fedorova, Tatyana D, Okkels, Niels, Schaeffer, Eva, Bonkat, Sarah K, Geday, Jacob, Otto, Marit, Sommerauer, Michael, Danielsen, Erik H, Bech, Einar, Kraft, Jonas, Munk, Ole L, Hansen, Sandra D, Pavese, Nicola, Göder, Robert, Brooks, David J, Berg, Daniela, Borghammer, Per

“…Parkinson's disease is characterized by the presence of abnormal, intraneuronal α-synuclein aggregates, which may propagate from cell-to-cell in a prion-like…”
Get full text

Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease by Fan, Zhen, Okello, Aren A, Brooks, David J, Edison, Paul

“…Amyloid deposition, tangle formation, neuroinflammation and neuronal dysfunction are pathological processes involved in Alzheimer's disease. However, the…”
Get full text

The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study by Ismail, Rola, Parbo, Peter, Madsen, Lasse Stensvig, Hansen, Allan K, Hansen, Kim V, Schaldemose, Jeppe L, Kjeldsen, Pernille L, Stokholm, Morten G, Gottrup, Hanne, Eskildsen, Simon F, Brooks, David J

“…The aim of this longitudinal study was to assess with positron emission tomography (PET) the relationship between levels of inflammation and the loads of…”
Get full text

Trial of Cinpanemab in Early Parkinson’s Disease by Lang, Anthony E., Siderowf, Andrew D., Macklin, Eric A., Poewe, Werner, Brooks, David J., Fernandez, Hubert H., Rascol, Olivier, Giladi, Nir, Stocchi, Fabrizio, Tanner, Caroline M., Postuma, Ronald B., Simon, David K., Tolosa, Eduardo, Mollenhauer, Brit, Cedarbaum, Jesse M., Fraser, Kyle, Xiao, James, Evans, Karleyton C., Graham, Danielle L., Sapir, Inbal, Inra, Jennifer, Hutchison, R. Matthew, Yang, Minhua, Fox, Tara, Budd Haeberlein, Samantha, Dam, Tien

“…In a phase 2 trial in early Parkinson’s disease, treatment with cinpanemab, a monoclonal antibody to α-synuclein, did not affect clinical or imaging…”
Get full text

Role of Neuroinflammation in the Trajectory of Alzheimer's Disease and in vivo Quantification Using PET by Edison, Paul, Brooks, David J

“…Recent evidence suggests that neuroinflammation and immunity play a significant role in Alzheimer's disease and other neurodegenerative diseases. It has also…”
Get more information

Imaging synucleinopathies by Brooks, David J., Tambasco, Nicola

“…ABSTRACT In this review the structural and functional imaging changes associated with the synucleinopathies PD, MSA, and dementias associated with Lewy bodies…”
Get full text

Health-related quality of life in early Parkinson's disease: The impact of nonmotor symptoms by Duncan, Gordon W., Khoo, Tien K., Yarnall, Alison J., O'Brien, John T., Coleman, Shirley Y., Brooks, David J., Barker, Roger A., Burn, David J.

“…ABSTRACT Nonmotor symptoms (NMS) are common in patients with established Parkinson's disease (PD) and have a major impact upon quality of life. We investigated…”
Get full text

Proposed neuroimaging criteria for the diagnosis of multiple system atrophy by Brooks, David J., Seppi, Klaus

“…In this article, we review the state of the art knowledge concerning structural and functional imaging in multiple system atrophy (MSA). The relative value of…”
Get full text

Serotonergic mechanisms responsible for levodopa-induced dyskinesias in Parkinson's disease patients by Politis, Marios, Wu, Kit, Loane, Clare, Brooks, David J, Kiferle, Lorenzo, Turkheimer, Federico E, Bain, Peter, Molloy, Sophie, Piccini, Paola

“…Levodopa-induced dyskinesias (LIDs) are the most common and disabling adverse motor effect of therapy in Parkinson's disease (PD) patients. In this study, we…”
Get full text

The noradrenergic subtype of Parkinson disease: from animal models to clinical practice by Ray Chaudhuri, K., Leta, Valentina, Bannister, Kirsty, Brooks, David J., Svenningsson, Per

“…Many advances in understanding the pathophysiology of Parkinson disease (PD) have been based on research addressing its motor symptoms and phenotypes. Various…”
Get full text

Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease by Parbo, Peter, Ismail, Rola, Hansen, Kim V, Amidi, Ali, Mårup, Frederik H, Gottrup, Hanne, Brændgaard, Hans, Eriksson, Bengt O, Eskildsen, Simon F, Lund, Torben E, Tietze, Anna, Edison, Paul, Pavese, Nicola, Stokholm, Morten G, Borghammer, Per, Hinz, Rainer, Aanerud, Joel, Brooks, David J

“…See Kreisl (doi:10.1093/awx151) for a scientific commentary on this article.Subjects with mild cognitive impairment associated with cortical amyloid-β have a…”
Get full text

Inflammation after trauma: Microglial activation and traumatic brain injury by Ramlackhansingh, Anil F., Brooks, David J., Greenwood, Richard J., Bose, Subrata K., Turkheimer, Federico E., Kinnunen, Kirsi M., Gentleman, Steve, Heckemann, Rolf A., Gunanayagam, Karen, Gelosa, Giorgio, Sharp, David J.

“…Objective: Patient outcome after traumatic brain injury (TBI) is highly variable. The underlying pathophysiology of this is poorly understood, but inflammation…”
Get full text

The spectrum of nonmotor symptoms in early Parkinson disease by KHOO, Tien K, YARNALL, Alison J, DUNCAN, Gordon W, COLEMAN, Shirley, O'BRIEN, John T, BROOKS, David J, BARKER, Roger A, BURN, David J

“…Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) but their frequency in early PD has not been extensively studied. Our…”
Get full text

Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein by Fan, Zhen, Calsolaro, Valeria, Atkinson, Rebecca A, Femminella, Grazia D, Waldman, Adam, Buckley, Christopher, Trigg, William, Brooks, David J, Hinz, Rainer, Edison, Paul

“…Neuroinflammation is associated with neurodegenerative disease. PET radioligands targeting the 18-kDa translocator protein (TSPO) have been used as in vivo…”
Get full text

Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia by Fan, Zhen, Aman, Yahyah, Ahmed, Imtiaz, Chetelat, Gaël, Landeau, Brigitte, Ray Chaudhuri, K, Brooks, David J, Edison, Paul

“…Abstract Background Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common neurodegenerative diseases characterized by progressive neuronal…”
Get full text

Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease? by Duncan, Gordon W., Firbank, Michael J., Yarnall, Alison J., Khoo, Tien K., Brooks, David J., Barker, Roger A., Burn, David J., O'Brien, John T.

“…ABSTRACT Background The aim of this work was to investigate the cortical and white matter changes that underlie cognitive impairment in patients with incident…”
Get full text

PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats by Thomsen, Majken B., Ferreira, Sara A., Schacht, Anna C., Jacobsen, Jan, Simonsen, Mette, Betzer, Cristine, Jensen, Poul H., Brooks, David J., Landau, Anne M., Romero-Ramos, Marina

“…Alpha-synuclein (a-syn) can aggregate and form toxic oligomers and insoluble fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies…”
Get full text

Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART by GARVEY, Lucy J, PAVESE, Nicola, POLITIS, Marios, RAMLACKHANSINGH, Anil, BROOKS, David J, TAYLOR-ROBINSON, Simon D, WINSTON, Alan

“…Neuroinflammation plays an important role in HIV-associated neurological disorders; however, its role prior to the onset of symptomatic disease is unclear. We…”
Get full text

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis by Sperling, Reisa, Dr, Salloway, Stephen, Prof, Brooks, David J, Prof, Tampieri, Donatella, MD, Barakos, Jerome, MD, Fox, Nick C, Prof, Raskind, Murray, Prof, Sabbagh, Marwan, MD, Honig, Lawrence S, MD, Porsteinsson, Anton P, Prof, Lieberburg, Ivan, MD, Arrighi, H Michael, PhD, Morris, Kristen A, MS, Lu, Yuan, MS, Liu, Enchi, PhD, Gregg, Keith M, PhD, Brashear, H Robert, MD, Kinney, Gene G, PhD, Black, Ronald, MD, Grundman, Michael, MD

“…Summary Background Amyloid-related imaging abnormalities (ARIA) have been reported in patients with Alzheimer's disease treated with bapineuzumab, a humanised…”
Get full text