Search Results - "Brooks, David G"

Type I Interferon in Chronic Virus Infection and Cancer by Snell, Laura M, McGaha, Tracy L, Brooks, David G

“…Type I interferons (IFN-Is) are emerging as key drivers of inflammation and immunosuppression in chronic infection. Control of these infections requires IFN-I…”
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Opposing Roles of Type I Interferons in Cancer Immunity by Boukhaled, Giselle M, Harding, Shane, Brooks, David G

“…The immune system is tasked with identifying malignant cells to eliminate or prevent cancer spread. This involves a complex orchestration of many immune cell…”
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IL-21 Is Required to Control Chronic Viral Infection by Elsaesser, Heidi, Sauer, Karsten, Brooks, David G

“…CD4⁺ and CD8⁺ T cell functions are rapidly aborted during chronic infection, preventing viral clearance. CD4⁺ T cell help is required throughout chronic…”
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Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection by Wilson, Elizabeth B., Yamada, Douglas H., Elsaesser, Heidi, Herskovitz, Jonathan, Deng, Jane, Cheng, Genhong, Aronow, Bruce J., Karp, Christopher L., Brooks, David G.

“…Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease…”
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Rapid detection of Mycobacterium tuberculosis by recombinase polymerase amplification by Boyle, David S, McNerney, Ruth, Teng Low, Hwee, Leader, Brandon Troy, Pérez-Osorio, Ailyn C, Meyer, Jessica C, O'Sullivan, Denise M, Brooks, David G, Piepenburg, Olaf, Forrest, Matthew S

“…Improved access to effective tests for diagnosing tuberculosis (TB) has been designated a public health priority by the World Health Organisation. In high…”
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Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials by Gadalla, Ramy, Noamani, Babak, MacLeod, Bethany L, Dickson, Russell J, Guo, Mengdi, Xu, Wenxi, Lukhele, Sabelo, Elsaesser, Heidi J, Razak, Albiruni R Abdul, Hirano, Naoto, McGaha, Tracy L, Wang, Ben, Butler, Marcus, Guidos, Cynthia J, Ohashi, Pam S, Siu, Lillian L, Brooks, David G

“…Flow cytometry is a widely applied approach for exploratory immune profiling and biomarker discovery in cancer and other diseases. However, flow cytometry is…”
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Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection by Snell, Laura M., Osokine, Ivan, Yamada, Douglas H., De la Fuente, Justin Rafael, Elsaesser, Heidi J., Brooks, David G.

“…Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of…”
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Networking at the Level of Host Immunity: Immune Cell Interactions during Persistent Viral Infections by Ng, Cherie T., Snell, Laura M., Brooks, David G., Oldstone, Michael B.A.

“…Persistent viral infections are the result of a series of connected events that culminate in diminished immunity and the inability to eliminate infection. By…”
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IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection by Brooks, David G, Ha, Sang-Jun, Elsaesser, Heidi, Sharpe, Arlene H, Freeman, Gordon J, Oldstone, Michael B.A

“…Suppression of T-cell responses by host-derived regulatory factors is a key event leading to viral persistence. Antibody blockade of either IL-10 or programmed…”
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Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control by Guo, Mengdi, Abd-Rabbo, Diala, Bertol, Bruna C., Carew, Madeleine, Lukhele, Sabelo, Snell, Laura M., Xu, Wenxi, Boukhaled, Giselle M., Elsaesser, Heidi, Halaby, Marie Jo, Hirano, Naoto, McGaha, Tracy L., Brooks, David G.

“…CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation of CD4 tumor-specific T (TTS) cells is unclear. We demonstrate…”
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Cardiolipin provides an essential activating platform for caspase-8 on mitochondria by Gonzalvez, Francois, Schug, Zachary T, Houtkooper, Riekelt H, MacKenzie, Elaine D, Brooks, David G, Wanders, Ronald J.A, Petit, Patrice X, Vaz, Frédéric M, Gottlieb, Eyal

“…Cardiolipin is a mitochondria-specific phospholipid known to be intimately involved with apoptosis. However, the lack of appropriate cellular models to date…”
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IL-10 Directly Suppresses CD4 but Not CD8 T Cell Effector and Memory Responses Following Acute Viral Infection by Brooks, David G., Walsh, Kevin B., Elsaesser, Heidi, Oldstone, Michael B. A.

“…Mounting effective T cell responses is critical for eliciting longlasting immunity following viral infection and vaccination. A multitude of inhibitory and…”
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Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses by Gillespie, Eugene J, Ho, Chi-Lee C, Balaji, Kavitha, Clemens, Daniel L, Deng, Gang, Wang, Yao E, Elsaesser, Heidi J, Tamilselvam, Batcha, Gargi, Amandeep, Dixon, Shandee D, France, Bryan, Chamberlain, Brian T, Blanke, Steven R, Cheng, Genhong, de la Torre, Juan Carlos, Brooks, David G, Jung, Michael E, Colicelli, John, Damoiseaux, Robert, Bradley, Kenneth A

“…Pathogenic microorganisms and toxins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert virulent effects upon the…”
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Emergence of Distinct Multiarmed Immunoregulatory Antigen-Presenting Cells during Persistent Viral Infection by Wilson, Elizabeth B., Kidani, Yoko, Elsaesser, Heidi, Barnard, Jennifer, Raff, Laura, Karp, Christopher L., Bensinger, Steven, Brooks, David G.

“…During persistent viral infection, adaptive immune responses are suppressed by immunoregulatory factors, contributing to viral persistence. Although this…”
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CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses by Woo, Jin Seok, Srikanth, Sonal, Kim, Kyun-Do, Elsaesser, Heidi, Lu, Jing, Pellegrini, Matteo, Brooks, David G, Sun, Zuoming, Gwack, Yousang

“…Ca release-activated Ca channel regulator 2A (CRACR2A) is expressed abundantly in T cells and acts as a signal transmitter between TCR stimulation and…”
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Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence by Cunningham, Cameron R, Champhekar, Ameya, Tullius, Michael V, Dillon, Barbara Jane, Zhen, Anjie, de la Fuente, Justin Rafael, Herskovitz, Jonathan, Elsaesser, Heidi, Snell, Laura M, Wilson, Elizabeth B, de la Torre, Juan Carlos, Kitchen, Scott G, Horwitz, Marcus A, Bensinger, Steven J, Smale, Stephen T, Brooks, David G

“…Persistent viral infections are simultaneously associated with chronic inflammation and highly potent immunosuppressive programs mediated by IL-10 and PDL1…”
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Prevention of CD8 T Cell Deletion during Chronic Viral Infection by Brooks, David G, Tishon, Antoinette, Oldstone, Michael B A, McGavern, Dorian B

“…During chronic viral infections, CD8 T cells rapidly lose antiviral and immune-stimulatory functions in a sustained program termed exhaustion. In addition to…”
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Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer by Lheureux, Stephanie, Matei, Daniela E, Konstantinopoulos, Panagiotis A, Wang, Ben X, Gadalla, Ramy, Block, Matthew S, Jewell, Andrea, Gaillard, Stephanie L, McHale, Michael, McCourt, Carolyn, Temkin, Sarah, Girda, Eugenia, Backes, Floor J, Werner, Theresa L, Duska, Linda, Kehoe, Siobhan, Colombo, Ilaria, Wang, Lisa, Li, Xuan, Wildman, Rachel, Soleimani, Shirin, Lien, Scott, Wright, John, Pugh, Trevor, Ohashi, Pamela S, Brooks, David G, Fleming, Gini F

“…BackgroundCombining immunotherapy and antiangiogenic agents is a promising treatment strategy in endometrial cancer. To date, no biomarkers for response have…”
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Inflammation Makes T Cells Sensitive by Wilson, Elizabeth B., Brooks, David G.

“…Inflammatory cytokines shape CD8+ T cell responses. In this issue of Immunity, Richer et al. (2013) and Raue et al. (2013) demonstrate that inflammatory…”
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Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection by BROOKS, David G, TEYTON, Luc, OLDSTONE, Michael B. A, MCGAVERN, Dorian B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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