Search Results - "Brooks, David"

Molecular imaging of dopamine transporters by Brooks, David J

“…Abstract The dopamine transporter (DAT) is responsible for clearance of dopamine from the synaptic cleft after its release. Imaging DAT availability provides a…”
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Type I Interferon in Chronic Virus Infection and Cancer by Snell, Laura M, McGaha, Tracy L, Brooks, David G

“…Type I interferons (IFN-Is) are emerging as key drivers of inflammation and immunosuppression in chronic infection. Control of these infections requires IFN-I…”
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An early and late peak in microglial activation in Alzheimer's disease trajectory by Fan, Zhen, Brooks, David J, Okello, Aren, Edison, Paul

“…Amyloid-β deposition, neuroinflammation and tau tangle formation all play a significant role in Alzheimer's disease. We hypothesized that there is microglial…”
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Age at onset and Parkinson disease phenotype by Pagano, Gennaro, Ferrara, Nicola, Brooks, David J, Pavese, Nicola

“…OBJECTIVE:To explore clinical phenotype and characteristics of Parkinson disease (PD) at different ages at onset in recently diagnosed patients with untreated…”
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Imaging approaches to Parkinson disease by Brooks, David J

“…Parkinson disease (PD) is associated with nigral degeneration and striatal dopamine deficiency. Demonstrating midbrain structural abnormalities with…”
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Opposing Roles of Type I Interferons in Cancer Immunity by Boukhaled, Giselle M, Harding, Shane, Brooks, David G

“…The immune system is tasked with identifying malignant cells to eliminate or prevent cancer spread. This involves a complex orchestration of many immune cell…”
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Properties of the Diffuse Emission around Warm Loops in Solar Active Regions by Brooks, David H.

“…Coronal loops in active regions are the subjects of intensive investigation, but the important diffuse unresolved emission in which they are embedded has…”
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MEASUREMENTS OF NON-THERMAL LINE WIDTHS IN SOLAR ACTIVE REGIONS by Brooks, David H., Warren, Harry P.

“…ABSTRACT Spectral line widths are often observed to be larger than can be accounted for by thermal and instrumental broadening alone. This excess broadening is…”
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Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease by Dani, Melanie, Wood, Melanie, Mizoguchi, Ruth, Fan, Zhen, Walker, Zuzana, Morgan, Richard, Hinz, Rainer, Biju, Maya, Kuruvilla, Tarun, Brooks, David J, Edison, Paul

“…The relationship between microglial activation and protein aggregation in Alzheimer's disease is still debated. Dani et al. report that in vivo microglial…”
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IL-21 Is Required to Control Chronic Viral Infection by Elsaesser, Heidi, Sauer, Karsten, Brooks, David G

“…CD4⁺ and CD8⁺ T cell functions are rapidly aborted during chronic infection, preventing viral clearance. CD4⁺ T cell help is required throughout chronic…”
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Full-Sun observations for identifying the source of the slow solar wind by Brooks, David H., Ugarte-Urra, Ignacio, Warren, Harry P.

“…Fast (>700 km s −1 ) and slow (~400 km s −1 ) winds stream from the Sun, permeate the heliosphere and influence the near-Earth environment. While the fast wind…”
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Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease by Leng, Fangda, Hinz, Rainer, Gentleman, Steve, Hampshire, Adam, Dani, Melanie, Brooks, David J., Edison, Paul

“…Brain network dysfunction is increasingly recognised in Alzheimer’s disease (AD). However, the causes of brain connectivity disruption are still poorly…”
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Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism by Brooks, David J.

“…In this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are…”
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The Role of Neuroinflammation in Dementias by Pasqualetti, Giuseppe, Brooks, David J., Edison, Paul

“…The molecular mechanism of neuronal loss and synaptic damage in Alzheimer’s disease (AD), Parkinson’s disease dementia (PDD), frontotemporal dementia (FTD) and…”
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Type I interferon signaling, regulation and gene stimulation in chronic virus infection by Lukhele, Sabelo, Boukhaled, Giselle M., Brooks, David G.

“…Type I Interferons (IFN-I) mediate numerous immune interactions during viral infections, from the establishment of an antiviral state to invoking and…”
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Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study by Horsager, Jacob, Andersen, Katrine B, Knudsen, Karoline, Skjærbæk, Casper, Fedorova, Tatyana D, Okkels, Niels, Schaeffer, Eva, Bonkat, Sarah K, Geday, Jacob, Otto, Marit, Sommerauer, Michael, Danielsen, Erik H, Bech, Einar, Kraft, Jonas, Munk, Ole L, Hansen, Sandra D, Pavese, Nicola, Göder, Robert, Brooks, David J, Berg, Daniela, Borghammer, Per

“…Parkinson's disease is characterized by the presence of abnormal, intraneuronal α-synuclein aggregates, which may propagate from cell-to-cell in a prion-like…”
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Future Imaging in Dementia by Brooks, David J.

“…Imaging has made an immense contribution toward supporting the diagnosis of dementias, detecting preclinical and prodromal pathology, and allowing disease…”
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Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis by Dyson, Matthew T, Roqueiro, Damian, Monsivais, Diana, Ercan, C Mutlu, Pavone, Mary Ellen, Brooks, David C, Kakinuma, Toshiyuki, Ono, Masanori, Jafari, Nadereh, Dai, Yang, Bulun, Serdar E

“…Endometriosis is a gynecological disease defined by the extrauterine growth of endometrial-like cells that cause chronic pain and infertility. The disease is…”
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A SYSTEMATIC SURVEY OF HIGH-TEMPERATURE EMISSION IN SOLAR ACTIVE REGIONS by WARREN, Harry P, WINEBARGER, Amy R, BROOKS, David H

“…The recent analysis of observations taken with the EUV Imaging Spectrometer and X-Ray Telescope instruments on Hinode suggests that well-constrained…”
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A Diagnostic of Coronal Elemental Behavior during the Inverse FIP Effect in Solar Flares by Brooks, David H.

“…The solar corona shows a distinctive pattern of elemental abundances that is different from that of the photosphere. Low first ionization potential (FIP)…”
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