Search Results - "Brooks, DJ"

Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease by Lang, Anthony E., Gill, Steven, Patel, Nik K., Lozano, Andres, Nutt, John G., Penn, Richard, Brooks, David J., Hotton, Gary, Moro, Elena, Heywood, Peter, Brodsky, Matthew A., Burchiel, Kim, Kelly, Patrick, Dalvi, Arif, Scott, Burton, Stacy, Mark, Turner, Dennis, Wooten, V. G. Frederich, Elias, William J., Laws, Edward R., Dhawan, Vijay, Stoessl, A. Jon, Matcham, James, Coffey, Robert J., Traub, Michael

“…Objective Glial cell line–derived neurotrophic factor (GDNF) exerts potent trophic influence on midbrain dopaminergic neurons. This randomized controlled…”
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Compulsive drug use linked to sensitized ventral striatal dopamine transmission by Evans, Andrew H., Pavese, Nicola, Lawrence, Andrew D., Tai, Yen F., Appel, Silke, Doder, Miroslava, Brooks, David J., Lees, Andrew J., Piccini, Paola

“…Objective A small group of Parkinson's disease (PD) patients compulsively use dopaminergic drugs despite causing harmful social, psychological, and physical…”
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The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study by von Spiczak, Sarah, Whone, Alan L., Hammers, Alexander, Asselin, Marie-Claude, Turkheimer, Federico, Tings, Tobias, Happe, Svenja, Paulus, Walter, Trenkwalder, Claudia, Brooks, David J.

“…Opioids have been shown to provide symptomatic relief from dysaesthesias and motor symptoms in restless legs syndrome (RLS). However, the mechanisms by which…”
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Reward Processing in Health and Parkinson’s Disease: Neural Organization and Reorganization by Goerendt, Ines K., Lawrence, Andrew D., Brooks, David J.

“…It has been suggested that motivational processes mediated by dopaminergic neural systems may be relatively spared in Parkinson’s disease (PD) and activation…”
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Neuroinflammation in Alzheimer's disease by Heneka, Michael T, Prof, Carson, Monica J, Prof, Khoury, Joseph El, Prof, Landreth, Gary E, Prof, Brosseron, Frederic, PhD, Feinstein, Douglas L, Prof, Jacobs, Andreas H, Prof, Wyss-Coray, Tony, Prof, Vitorica, Javier, Prof, Ransohoff, Richard M, Prof, Herrup, Karl, Prof, Frautschy, Sally A, Prof, Finsen, Bente, Prof, Brown, Guy C, Prof, Verkhratsky, Alexei, Prof, Yamanaka, Koji, Prof, Koistinaho, Jari, Prof, Latz, Eicke, Prof, Halle, Annett, MD, Petzold, Gabor C, Prof, Town, Terrence, Prof, Morgan, Dave, Prof, Shinohara, Mari L, Prof, Perry, V Hugh, Prof, Holmes, Clive, Prof, Bazan, Nicolas G, Prof, Brooks, David J, Prof, Hunot, Stéphane, PhD, Joseph, Bertrand, Prof, Deigendesch, Nikolaus, MD, Garaschuk, Olga, Prof, Boddeke, Erik, Prof, Dinarello, Charles A, Prof, Breitner, John C, Prof, Cole, Greg M, Prof, Golenbock, Douglas T, Prof, Kummer, Markus P, PhD

“…Summary Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with…”
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Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy by Obeso, J.A., Stamelou, M., Goetz, C.G., Poewe, W., Lang, A.E., Weintraub, D., Burn, D., Halliday, G.M., Bezard, E., Przedborski, S., Lehericy, S., Brooks, D.J., Rothwell, J.C., Hallett, M., DeLong, M.R., Marras, C., Tanner, C.M., Ross, G.W., Langston, J.W., Klein, C., Bonifati, V., Jankovic, J., Lozano, A.M., Deuschl, G., Bergman, H., Tolosa, E., Rodriguez‐Violante, M., Fahn, S., Postuma, R.B., Berg, D., Marek, K., Standaert, D.G., Surmeier, D.J., Olanow, C.W., Kordower, J.H., Calabresi, P., Schapira, A.H.V., Stoessl, A.J.

“…ABSTRACT This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he…”
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EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0 by Morbelli, Silvia, Esposito, Giuseppe, Arbizu, Javier, Barthel, Henryk, Boellaard, Ronald, Bohnen, Nico I., Brooks, David J, Darcourt, Jacques, Dickson, John C., Douglas, David, Drzezga, Alexander, Dubroff, Jacob, Ekmekcioglu, Ozgul, Garibotto, Valentina, Herscovitch, Peter, Kuo, Phillip, Lammertsma, Adriaan, Pappata, Sabina, Peñuelas, Iván, Seibyl, John, Semah, Franck, Tossici-Bolt, Livia, Van de Giessen, Elsmarieke, Van Laere, Koen, Varrone, Andrea, Wanner, Michele, Zubal, George, Law, Ian

“…Purpose This joint practice guideline or procedure standard was developed collaboratively by the European Association of Nuclear Medicine (EANM) and the…”
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Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum by Jansen, Willemijn J, Janssen, Olin, Tijms, Betty M, Vos, Stephanie J B, Ossenkoppele, Rik, Visser, Pieter Jelle, Aarsland, Dag, Alcolea, Daniel, Altomare, Daniele, von Arnim, Christine, Baiardi, Simone, Baldeiras, Ines, Barthel, Henryk, Bateman, Randall J, Van Berckel, Bart, Binette, Alexa Pichet, Blennow, Kaj, Boada, Merce, Boecker, Henning, Bottlaender, Michel, den Braber, Anouk, Brooks, David J, Van Buchem, Mark A, Camus, Vincent, Carill, Jose Manuel, Cerman, Jiri, Chen, Kewei, Chételat, Gaël, Chipi, Elena, Cohen, Ann D, Daniels, Alisha, Delarue, Marion, Didic, Mira, Drzezga, Alexander, Dubois, Bruno, Eckerström, Marie, Ekblad, Laura L, Engelborghs, Sebastiaan, Epelbaum, Stéphane, Fagan, Anne M, Fan, Yong, Fladby, Tormod, Fleisher, Adam S, Van der Flier, Wiesje M, Förster, Stefan, Fortea, Juan, Frederiksen, Kristian Steen, Freund-Levi, Yvonne, Frings, Lars, Frisoni, Giovanni B, Fröhlich, Lutz, Gabryelewicz, Tomasz, Gertz, Hermann-Josef, Gill, Kiran Dip, Gkatzima, Olymbia, Gómez-Tortosa, Estrella, Grimmer, Timo, Guedj, Eric, Habeck, Christian G, Hampel, Harald, Handels, Ron, Hansson, Oskar, Hausner, Lucrezia, Hellwig, Sabine, Heneka, Michael T, Herukka, Sanna-Kaisa, Hildebrandt, Helmut, Hodges, John, Hort, Jakub, Huang, Chin-Chang, Iriondo, Ane Juaristi, Itoh, Yoshiaki, Ivanoiu, Adrian, Jagust, William J, Jessen, Frank, Johannsen, Peter, Johnson, Keith A, Kandimalla, Ramesh, Kapaki, Elisabeth N, Kern, Silke, Kilander, Lena, Klimkowicz-Mrowiec, Aleksandra, Klunk, William E, Koglin, Norman, Kornhuber, Johannes, Kramberger, Milica G, Kuo, Hung-Chou, Van Laere, Koen, Landau, Susan M, Landeau, Brigitte, Lee, Dong Young, de Leon, Mony, Leyton, Cristian E, Lin, Kun-Ju, Lleó, Alberto, Löwenmark, Malin, Madsen, Karine, Maier, Wolfgang, Marcusson, Jan, Marquié, Marta

“…One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal…”
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The noradrenergic subtype of Parkinson disease: from animal models to clinical practice by Ray Chaudhuri, K., Leta, Valentina, Bannister, Kirsty, Brooks, David J., Svenningsson, Per

“…Many advances in understanding the pathophysiology of Parkinson disease (PD) have been based on research addressing its motor symptoms and phenotypes. Various…”
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Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial by Rascol, O, Brooks, DJ, Melamed, E, Oertel, W, Poewe, W, Stocchi, F, Tolosa, E

“…Rasagiline mesylate is a novel drug for Parkinson's disease with selective, irreversible monoamine oxidase B (MAO-B) inhibitor activity, and is effective as…”
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Imaging markers for Alzheimer disease: Which vs how by Frisoni, Giovanni B, Bocchetta, Martina, Chételat, Gael, Rabinovici, Gil D, de Leon, Mony J, Kaye, Jeffrey, Reiman, Eric M, Scheltens, Philip, Barkhof, Frederik, Black, Sandra E, Brooks, David J, Carrillo, Maria C, Fox, Nick C, Herholz, Karl, Nordberg, Agneta, Jack, Clifford R, Jagust, William J, Johnson, Keith A, Rowe, Christopher C, Sperling, Reisa A, Thies, William, Wahlund, Lars-Olof, Weiner, Michael W, Pasqualetti, Patrizio, DeCarli, Charles

“…Revised diagnostic criteria for Alzheimer disease (AD) acknowledge a key role of imaging biomarkers for early diagnosis. Diagnostic accuracy depends on which…”
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In vivo imaging of microglial activation with [ 11C]( R)-PK11195 PET in idiopathic Parkinson's disease by Gerhard, Alexander, Pavese, Nicola, Hotton, Gary, Turkheimer, Federico, Es, Meltem, Hammers, Alexander, Eggert, Karla, Oertel, Wolfgang, Banati, Richard B., Brooks, David J.

“…Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder associated with akinesia, tremor and rigidity. While the characteristic Lewy body pathology…”
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Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease by Martinez-Martin, Pablo, Falup Pecurariu, Cristian, Odin, Per, van Hilten, Jacobus J., Antonini, Angelo, Rojo-Abuin, Jose M., Borges, Vanderci, Trenkwalder, Claudia, Aarsland, Dag, Brooks, David J., Ray Chaudhuri, Kallol

“…Differences in the expression of non-motor symptoms (NMS) by Parkinson’s disease (PD) patients may have important implications for their management and…”
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Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice by Devlin, M J, Brooks, D J, Conlon, C, Vliet, M van, Louis, L, Rosen, C J, Bouxsein, M L

“…Starvation induces low bone mass and high bone marrow adiposity in humans, but the underlying mechanisms are poorly understood. The adipokine leptin falls in…”
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Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease by Mattsson, Niklas, Groot, Colin, Jansen, Willemijn J., Landau, Susan M., Villemagne, Victor L., Engelborghs, Sebastiaan, Mintun, Mark M., Lleo, Alberto, Molinuevo, José Luis, Jagust, William J., Frisoni, Giovanni B., Ivanoiu, Adrian, Chételat, Gaël, Resende de Oliveira, Catarina, Rodrigue, Karen M., Kornhuber, Johannes, Wallin, Anders, Klimkowicz-Mrowiec, Aleksandra, Kandimalla, Ramesh, Popp, Julius, Aalten, Pauline P., Aarsland, Dag, Alcolea, Daniel, Almdahl, Ina S., Baldeiras, Inês, van Buchem, Mark A., Cavedo, Enrica, Chen, Kewei, Cohen, Ann D., Förster, Stefan, Fortea, Juan, Frederiksen, Kristian S., Freund-Levi, Yvonne, Gill, Kiran Dip, Gkatzima, Olymbia, Grimmer, Timo, Hampel, Harald, Herukka, Sanna-Kaisa, Johannsen, Peter, van Laere, Koen, de Leon, Mony J., Maier, Wolfgang, Marcusson, Jan, Meulenbroek, Olga, Møllergård, Hanne M., Morris, John C., Mroczko, Barbara, Nordlund, Arto, Prabhakar, Sudesh, Peters, Oliver, Rami, Lorena, Rodríguez-Rodríguez, Eloy, Roe, Catherine M., Rüther, Eckart, Santana, Isabel, Schröder, Johannes, Seo, Sang W., Soininen, Hilkka, Spiru, Luiza, Stomrud, Erik, Struyfs, Hanne, Teunissen, Charlotte E., Verhey, Frans R.J., Vos, Stephanie J.B., van Waalwijk van Doorn, Linda J.C., Waldemar, Gunhild, Wallin, Åsa K., Wiltfang, Jens, Vandenberghe, Rik, Brooks, David J., Fladby, Tormod, Rowe, Christopher C., Drzezga, Alexander, Verbeek, Marcel M., Sarazin, Marie, Wolk, David A., Fleisher, Adam S., Klunk, William E., Na, Duk L., Sánchez-Juan, Pascual, Lee, Dong Young, Nordberg, Agneta, Tsolaki, Magda, Camus, Vincent, Rinne, Juha O., Fagan, Anne M., Zetterberg, Henrik, Blennow, Kaj, Rabinovici, Gil D., Hansson, Oskar, van Berckel, Bart N.M., van der Flier, Wiesje M., Scheltens, Philip, Visser, Pieter Jelle, Ossenkoppele, Rik

“…Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require…”
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Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe by Hammers, Alexander, Allom, Richard, Koepp, Matthias J., Free, Samantha L., Myers, Ralph, Lemieux, Louis, Mitchell, Tejal N., Brooks, David J., Duncan, John S.

“…Probabilistic atlases of neuroanatomy are more representative of population anatomy than single brain atlases. They allow anatomical labeling of the results of…”
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DLB and PDD boundary issues : Diagnosis, treatment, molecular pathology, and biomarkers by LIPPA, C. F, DUDA, J. E, FAHN, S, FARMER, J. M, GALASKO, D, GALVIN, J. E, GOETZ, C. G, GROWDON, J. H, GWINN-HARDY, K. A, HARDY, J, HEUTINK, P, IWATSUBO, T, GROSSMAN, M, KOSAKA, K, LEE, V. M.-Y, LEVERENZ, J. B, MASLIAH, E, MCKEITH, I. G, NUSSBAUM, R. L, OLANOW, C. W, RAVINA, B. M, SINGLETON, A. B, TANNER, C. M, HURTIG, H. I, TROJANOWSKI, J. Q, WSZOLEK, Z. K, AARSLAND, D, BOEVE, B. F, BROOKS, D. J, DICKSON, D. W, DUBOIS, B, EMRE, M

“…For more than a decade, researchers have refined criteria for the diagnosis of dementia with Lewy bodies (DLB) and at the same time have recognized that…”
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Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease by Gill, Steven S, Svendsen, Clive N, Patel, Nikunj K, Hotton, Gary R, O'Sullivan, Karen, McCarter, Renée, Bunnage, Martin, Brooks, David J, Heywood, Peter

“…Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor with restorative effects in a wide variety of rodent and primate models of…”
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Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study by Whone, Alan L., Watts, Ray L., Stoessl, A. Jon, Davis, Margaret, Reske, Sven, Nahmias, Claude, Lang, Anthony E., Rascol, Olivier, Ribeiro, Maria J., Remy, Philippe, Poewe, Werner H., Hauser, Robert A., Brooks, David J.

“…Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot clinical study using 18F‐dopa…”
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Positron Emission Tomography and Single-Photon Emission Computed Tomography in Central Nervous System Drug Development by Brooks, David J.

“…In this review, the value of functional imaging [positron emission tomography (PET)/single-photon emission computed tomography (SPECT)] in drug development is…”
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