Search Results - "Brookheart, Rita T"

Association between obesity and bacterial vaginosis as assessed by Nugent score by Brookheart, Rita T., Lewis, Warren G., Peipert, Jeffrey F., Lewis, Amanda L., Allsworth, Jenifer E.

“…Bacterial vaginosis is 1 of the most common vaginal conditions in the United States. Recent studies have suggested that obese women have an abnormal microbiota…”
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Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress by Michel, Carlos I., Holley, Christopher L., Scruggs, Benjamin S., Sidhu, Rohini, Brookheart, Rita T., Listenberger, Laura L., Behlke, Mark A., Ory, Daniel S., Schaffer, Jean E.

“…Lipotoxicity is a metabolic stress response implicated in the pathogenesis of diabetes complications and has been shown to involve lipid-induced oxidative…”
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Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51 by Mousa, Muhammad G., Vuppaladhadiam, Lahari, Kelly, Meredith O., Pietka, Terri, Ek, Shelby, Shen, Karen C., Meyer, Gretchen A., Finck, Brian N., Brookheart, Rita T.

“…The mitochondrial response to changes in cellular energy demand is necessary for cellular adaptation and organ function. Many genes are essential in…”
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The Non-coding RNA gadd7 Is a Regulator of Lipid-induced Oxidative and Endoplasmic Reticulum Stress by Brookheart, Rita T., Michel, Carlos I., Listenberger, Laura L., Ory, Daniel S., Schaffer, Jean E.

“…In obesity and diabetes, an imbalance in fatty acid uptake and fatty acid utilization leads to excess accumulation of lipid in non-adipose tissues. This lipid…”
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Casein Kinase 1 Regulates Sterol Regulatory Element-binding Protein (SREBP) to Control Sterol Homeostasis by Brookheart, Rita T., Lee, Chih-Yung S., Espenshade, Peter J.

“…Sterol homeostasis is tightly controlled by the sterol regulatory element-binding protein (SREBP) transcription factor that is highly conserved from fungi to…”
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Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations by Chambers, Kari T, Cooper, Michael A, Swearingen, Alison R, Brookheart, Rita T, Schweitzer, George G, Weinheimer, Carla J, Kovacs, Attila, Koves, Timothy R, Muoio, Deborah M, McCommis, Kyle S, Finck, Brian N

“…Lipin 1 is a bifunctional protein that is a transcriptional regulator and has phosphatidic acid (PA) phosphohydrolase activity, which dephosphorylates PA to…”
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A mutation in Site‐1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema by Schweitzer, George G., Gan, Connie, Bucelli, Robert C., Wegner, Daniel, Schmidt, Robert E., Shinawi, Marwan, Finck, Brian N., Brookheart, Rita T.

“…Background Site‐1 Protease (S1P) is a Golgi‐resident protein required for the activation of regulatory proteins that drive key cellular functions, including,…”
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As a Matter of Fat by Brookheart, Rita T., Michel, Carlos I., Schaffer, Jean E.

“…Excess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease. When elevated lipid levels exceed the cell's capacity to store or…”
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Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry by Pietka, Terri A, Brookheart, Rita T

“…Mitochondrial function, a cornerstone of cellular energy production, is critical for maintaining metabolic homeostasis. Its dysfunction in skeletal muscle is…”
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Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism by McGuire, Meredith R., Mukhopadhyay, Debaditya, Myers, Stephanie L., Mosher, Eric P., Brookheart, Rita T., Kammers, Kai, Sehgal, Alfica, Selen, Ebru S., Wolfgang, Michael J., Bumpus, Namandjé N., Espenshade, Peter J.

“…Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein implicated in a wide range of cellular functions. We previously showed that…”
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Drosophila melanogaster: An emerging model of transgenerational effects of maternal obesity by Brookheart, Rita T., Duncan, Jennifer G.

“…The prevalence of obesity in the world is endemic with one rapidly growing health concern being maternal obesity. Obesity during pregnancy increases the risk…”
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Modeling dietary influences on offspring metabolic programming in Drosophila melanogaster by Brookheart, Rita T, Duncan, Jennifer G

“…The influence of nutrition on offspring metabolism has become a hot topic in recent years owing to the growing prevalence of maternal and childhood obesity…”
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Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice by Martino, Michael R, Habibi, Mohammad, Ferguson, Daniel, Brookheart, Rita T, Thyfault, John P, Meyer, Gretchen A, Lantier, Louise, Hughey, Curtis C, Finck, Brian N

“…Exercise robustly increases the glucose demands of skeletal muscle. This demand is met by not only muscle glycogenolysis but also accelerated liver glucose…”
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Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility by Franczyk, Michael P, Qi, Nathan, Stromsdorfer, Kelly L, Li, Chengcheng, Yamaguchi, Shintaro, Itoh, Hiroshi, Yoshino, Mihoko, Sasaki, Yo, Brookheart, Rita T, Finck, Brian N, DeBosch, Brian J, Klein, Samuel, Yoshino, Jun

“…Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme that regulates cellular energy metabolism in many cell types. The major purpose of the…”
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High-sucrose-induced maternal obesity disrupts ovarian function and decreases fertility in Drosophila melanogaster by Brookheart, Rita T., Swearingen, Alison R., Collins, Christina A., Cline, Laura M., Duncan, Jennifer G.

“…As the obesity epidemic worsens, the prevalence of maternal obesity is expected to rise. Both high-fat and high-sucrose diets are known to promote maternal…”
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Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility by Franczyk, Michael P, Qi, Nathan, Stromsdorfer, Kelly L, Li, Chengcheng, Yamaguchi, Shintaro, Itoh, Hiroshi, Yoshino, Mihoko, Sasaki, Yo, Brookheart, Rita T, Finck, Brian N, DeBosch, Brian J, Klein, Samuel, Yoshino, Jun

“…Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme that regulates cellular energy metabolism in many cell types. The major purpose of the…”
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Importance of Adipose Tissue NA[D.sup.+] Biology in Regulating Metabolic Flexibility by Franczyk, Michael P, Qi, Nathan, Stromsdorfer, Kelly L, Li, Chengcheng, Yamaguchi, Shintaro, Itoh, Hiroshi, Yoshino, Mihoko, Sasaki, Yo, Brookheart, Rita T, Finck, Brian N, DeBosch, Brian J, Klein, Samuel, Yoshino, Jun

“…Nicotinamide adenine dinucleotide (NA[D.sup.+]) is an essential coenzyme that regulates cellular energy metabolism in many cell types. The major purpose of the…”
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The Non-coding RNA gadd7 Is a Regulator of Lipid-induced Oxidative and Endoplasmic Reticulum StressS by Brookheart, Rita T., Michel, Carlos I., Listenberger, Laura L., Ory, Daniel S., Schaffer, Jean E.

“…In obesity and diabetes, an imbalance in fatty acid uptake and fatty acid utilization leads to excess accumulation of lipid in non-adipose tissues. This lipid…”
Get full text