Search Results - "Brookes, Simon J. H."

Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum by Rahman, Ahmed A., Robinson, Ainsley M., Brookes, Simon J. H., Eri, Rajaraman, Nurgali, Kulmira

“…Rectal prolapse is associated with diminished anal sensitivity and rectal motor activity. Both sensory and motor functions are controlled by the extrinsic and…”
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Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis by Dinning, Phil G, Wiklendt, Lukasz, Omari, Taher, Arkwright, John W, Spencer, Nick J, Brookes, Simon J H, Costa, Marcello

“…Propulsive contractions of circular muscle are largely responsible for the movements of content along the digestive tract. Mechanical and electrophysiological…”
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Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach by Zagorodnyuk, Vladimir P., Chen, Bao Nan, Brookes, Simon J. H.

“…Distension-sensitive vagal afferent fibres from the cardiac region of the guinea-pig stomach were recorded extracellularly, then filled with biotinamide, using…”
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Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium by Zagorodnyuk, Vladimir P., Brookes, Simon J. H., Spencer, Nick J., Gregory, Sarah

“…The guinea pig bladder is innervated by at least five distinct major classes of extrinsic sensory neurons. In this study, we have examined the mechanisms of…”
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Properties of the major classes of mechanoreceptors in the guinea pig bladder by Zagorodnyuk, Vladimir P., Gibbins, Ian L., Costa, Marcello, Brookes, Simon J. H., Gregory, Sarah J.

“…Sensory neurons represent an attractive target for pharmacological treatment of various bladder disorders. However the properties of major classes of…”
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Functional changes in low- and high-threshold afferents in obstruction-induced bladder overactivity by Zagorodnyuk, Vladimir P, Keightley, Lauren J, Brookes, Simon J H, Spencer, Nick J, Costa, Marcello, Nicholas, Sarah J

“…Neural mechanisms of lower urinary tract symptoms in obstruction-induced bladder overactivity remain unclear. We made the first single unit recordings from…”
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Roles of three distinct neurogenic motor patterns during pellet propulsion in guinea‐pig distal colon by Costa, Marcello, Keightley, Lauren J., Wiklendt, Lukasz, Hibberd, Timothy J., Arkwright, John W., Omari, Taher, Wattchow, David A., Zagorodnyuk, Vladimir, Brookes, Simon J. H., Dinning, Phil G., Spencer, Nick J.

“…Key points Enteric neural circuits enable isolated preparations of guinea‐pig distal colon to propel solid and fluid contents by a self‐sustaining…”
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Sympathetic Pathways Target Cholinergic Neurons in the Human Colonic Myenteric Plexus by Parker, Dominic R, Wiklendt, Lukasz, Humenick, Adam, Chen, Bao Nan, Sia, Tiong Cheng, Wattchow, David A, Dinning, Phil G, Brookes, Simon J H

“…The sympathetic nervous system inhibits human colonic motility largely by effects on enteric neurons. Noradrenergic axons, which branch extensively in the…”
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Automated Analysis Using a Bayesian Functional Mixed-Effects Model With Gaussian Process Responses for Wavelet Spectra of Spatiotemporal Colonic Manometry Signals by Wiklendt, Lukasz, Costa, Marcello, Scott, Mark S, Brookes, Simon J H, Dinning, Phil G

“…Manual analysis of human high-resolution colonic manometry data is time consuming, non-standardized and subject to laboratory bias. In this article we present…”
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Characterization of viscerofugal neurons in human colon by retrograde tracing and multi-layer immunohistochemistry by Chen, Bao Nan, Humenick, Adam G, Hibberd, Timothy James, Yew, Wai Ping, Wattchow, David A, Dinning, Phil G, Costa, Marcello, Spencer, Nick J, Brookes, Simon J H

“…Viscerofugal neurons (VFNs) have cell bodies in the myenteric plexus and axons that project to sympathetic prevertebral ganglia. In animals they activate…”
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Characterisation of parasympathetic ascending nerves in human colon by Johnson, Michaela E, Humenick, Adam, Peterson, Rochelle A, Costa, Marcello, Wattchow, David A, Sia, Tiong Cheng, Dinning, Phil G, Brookes, Simon J H

“…In the human large bowel, sacral parasympathetic nerves arise from S2 to S4, project to the pelvic plexus ("hypogastric plexus") and have post-ganglionic axons…”
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Characterization of putative interneurons in the myenteric plexus of human colon by Humenick, Adam, Chen, Bao Nan, Wattchow, David A., Zagorodnyuk, Vladimir P., Dinning, Phil G., Spencer, Nick J., Costa, Marcello, Brookes, Simon J. H.

“…Background The enteric nervous system contains multiple classes of neurons, distinguishable by morphology, immunohistochemical markers, and projections;…”
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Characterization of projections of longitudinal muscle motor neurons in human colon by Humenick, Adam, Chen, Bao Nan, Lauder, Chris I. W., Wattchow, David A., Zagorodnyuk, Vladimir P., Dinning, Phil G., Spencer, Nick J., Costa, Marcello, Brookes, Simon J. H.

“…Background The enteric nervous system contains inhibitory and excitatory motor neurons which modulate smooth muscle contractility. Cell bodies of longitudinal…”
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A Novel Method for Electrophysiological Analysis of EMG Signals Using MesaClip by Wiklendt, Lukasz, Brookes, Simon J. H., Costa, Marcello, Travis, Lee, Spencer, Nick J., Dinning, Phil G.

“…In electrophysiology, many methods have been proposed for the analysis of action potential firing frequencies. The aim of this study was to present an…”
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Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse by Zhang, Lei, Jones, Sarahlouise, Brody, Kate, Costa, Marcello, Brookes, Simon J H

“…A number of transient receptor potential (TRP) channels has recently been shown to mediate cutaneous thermosensitivity. Sensitivity to warm and cool stimuli…”
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Effects of Lactate on One Class of Group III (CT3) Muscle Afferents by Peterson, Rochelle A., König, Christine, Zimmermann, Katharina, Barry, Christine M., Wiklendt, Lukasz, Brookes, Simon J. H.

“…A class of Group III muscle afferent neurons has branching sensory terminals in connective tissue between layers of mouse abdominal muscles ("CT3 muscle…”
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Measurement of strains experienced by viscerofugal nerve cell bodies during mechanosensitive firing using digital image correlation by Palmer, Gwen, Hibberd, Timothy J, Roose, Tiina, Brookes, Simon J H, Taylor, Mark

“…Mechanosensory neurons detect physical events in the local environments of the tissues that they innervate. Studies of mechanosensitivity of neurons or nerve…”
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Characterization of the colonic response to bisacodyl in children with treatment‐refractory constipation by Heitmann, Paul T., Wiklendt, Lukasz, Thapar, Nikhil, Borrelli, Osvaldo, Di Lorenzo, Carlo, Yacob, Desalegn T., Baaleman, Desiree F., Vriesman, Mana H., Nurko, Samuel, El‐Chammas, Khalil, Kaul, Ajay, Benninga, Marc A., Koppen, Ilan J.N., Wattchow, David A., Brookes, Simon J.H., Dinning, Phil G.

“…Background Colonic manometry with intraluminal bisacodyl infusion can be used to assess colonic neuromuscular function in children with treatment‐refractory…”
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Neurochemical characterization of extrinsic nerves in myenteric ganglia of the guinea pig distal colon by Chen, Bao Nan, Sharrad, Dale F., Hibberd, Timothy J., Zagorodnyuk, Vladimir P., Costa, Marcello, Brookes, Simon J.H.

“…ABSTRACT Extrinsic nerves to the gut influence the absorption of water and electrolytes and expulsion of waste contents, largely via regulation of enteric…”
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Identification of Medium/High-Threshold Extrinsic Mechanosensitive Afferent Nerves to the Gastrointestinal Tract by Song, Xingyun, Chen, Bao Nan, Zagorodnyuk, Vladimir P, Lynn, Penny A, Blackshaw, L. Ashley, Grundy, David, Brunsden, Alan M, Costa, Marcello, Brookes, Simon J.H

“…Background & Aims Large distentions reliably evoke sensation from the noninflamed, nonischemic bowel, but the specialized afferent axonal structures…”
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