Search Results - "Brookes, S J"

Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high‐resolution fiber‐optic manometry by Dinning, P. G., Wiklendt, L., Maslen, L., Gibbins, I., Patton, V., Arkwright, J. W., Lubowski, D. Z., O'Grady, G., Bampton, P. A., Brookes, S. J., Costa, M.

“…Background Until recently, investigations of the normal patterns of motility of the healthy human colon have been limited by the resolution of in vivo…”
Get full text

Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial by Brunton, P. A., Davies, R. P. W., Burke, J. L., Smith, A., Aggeli, A., Brookes, S. J., Kirkham, J.

“…Key Points Describes a rationally-designed peptide-based biomaterial capable of infiltrating early caries lesions where it is thought to form scaffold-like…”
Get full text

Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses by Hughes, P A, Brierley, S M, Martin, C M, Brookes, S J H, Linden, D R, Blackshaw, L A

“…Intestinal infection evokes hypersensitivity in a subgroup of patients with irritable bowel syndrome (IBS) long after healing of the initial injury…”
Get more information

Neuromechanical factors involved in the formation and propulsion of fecal pellets in the guinea‐pig colon by Costa, M., Wiklendt, L., Simpson, P., Spencer, N. J., Brookes, S. J., Dinning, P. G.

“…Background The neuromechanical processes involved in the formation and propulsion of fecal pellets remain incompletely understood. Methods We analyzed motor…”
Get full text

Self-assembling Peptide Scaffolds Promote Enamel Remineralization by Kirkham, J., Firth, A., Vernals, D., Boden, N., Robinson, C., Shore, R.C., Brookes, S.J., Aggeli, A.

“…Rationally designed β-sheet-forming peptides that spontaneously form three-dimensional fibrillar scaffolds in response to specific environmental triggers may…”
Get full text

Electrophysiological and morphological changes in colonic myenteric neurons from chemotherapy‐treated patients: a pilot study by Carbone, S. E., Jovanovska, V., Brookes, S. J. H., Nurgali, K.

“…Background Patients receiving anticancer chemotherapy experience a multitude of gastrointestinal side‐effects. However, the causes of these symptoms are…”
Get full text

Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat by Costa, M, Dodds, K N, Wiklendt, L, Spencer, N J, Brookes, S J H, Dinning, P G

“…Gastrointestinal motility involves interactions between myogenic and neurogenic processes intrinsic to the gut wall. We have compared the presence of…”
Get more information

Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract by Berthoud, H. R., Blackshaw, L. A., Brookes, S. J. H., Grundy, D.

“…Here we discuss the neuroanatomy of extrinsic gastrointestinal (GI) afferent neurones, the relationship between structure and function and the role of…”
Get full text

Postoperative ileus—An ongoing conundrum by Wattchow, David, Heitmann, Paul, Smolilo, David, Spencer, Nick J., Parker, Dominic, Hibberd, Timothy, Brookes, Simon S. J., Dinning, Phil G., Costa, Marcello

“…Background Postoperative ileus is common and is a major clinical problem. It has been widely studied in patients and in experimental models in laboratory…”
Get full text

Hydrogen peroxide preferentially activates capsaicin‐sensitive high threshold afferents via TRPA1 channels in the guinea pig bladder by Nicholas, S, Yuan, S Y, Brookes, S J H, Spencer, N J, Zagorodnyuk, V P

“…Background and Purpose There is increasing evidence suggesting that ROS play a major pathological role in bladder dysfunction induced by bladder inflammation…”
Get full text

Sensory transmission in the gastrointestinal tract by Blackshaw, L. A., Brookes, S. J. H., Grundy, D., Schemann, M.

“…The gastrointestinal (GI) tract must balance ostensibly opposite functions. On the one hand, it must undertake the process of digestion and absorption of…”
Get full text

Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies by Brookes, S. J., Dinning, P. G., Gladman, M. A.

“…Colorectal physiology is complex and involves programmed, coordinated interaction between muscular and neuronal elements. Whilst a detailed understanding…”
Get full text

Identification and mechanosensitivity of viscerofugal neurons by Hibberd, T.J, Zagorodnyuk, V.P, Spencer, N.J, Brookes, S.J.H

“…Highlights ► Viscerofugal neurons are known as gastrointestinal interneurons. ► Identification of viscerofugal neurons in extracellular recordings has been…”
Get full text

Enamel matrix proteins; old molecules for new applications by Lyngstadaas, SP, Wohlfahrt, JC, Brookes, SJ, Paine, ML, Snead, ML, Reseland, JE

“…Structured Authors –  Lyngstadaas SP, Wohlfahrt JC, Brookes SJ, Paine ML, Snead ML, Reseland JE Emdogain® (enamel matrix derivative, EMD) is well recognized in…”
Get full text

Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon by Carbone, S. E., Dinning, P. G., Costa, M., Spencer, N. J., Brookes, S. J. H., Wattchow, D. A.

“…Background In animal models, enteric reflex pathways have potent effects on motor activity; their roles have been much less extensively studied in human gut…”
Get full text

Quantitative analysis of peristalsis in the guinea-pig small intestine using spatio-temporal maps by Hennig, G. W., Costa, M., Chen, B. N., Brookes, S. J. H.

“…Peristalsis was evoked in guinea-pig small intestine by slow fluid infusion and recorded onto video and digitized. Spatio-temporal maps of diameter and…”
Get full text

In Memoriam: Marcello Costa (1940–2024) – a pioneer of the enteric nervous system by Spencer, N. J., Brookes, S. J. H., Wattchow, D. A.

Get full text

Marcello Costa (1940–2024) by Spencer, N. J., Brookes, S. J., Wattchow, D. A.

Get full text

Predictions of soot and thermal radiation properties in confined turbulent jet diffusion flames by Brookes, S.J., Moss, J.B.

“…Computational modeling of well-documented jet diffusion flames, burning methane at atmospheric and elevated pressure, is presented. The main emphasis of the…”
Get full text

The effect of fluoride on the developing tooth by Robinson, C, Connell, S, Kirkham, J, Brookes, S J, Shore, R C, Smith, A M

“…This review aims to outline the effects of fluoride on the biological processes involved in the formation of tooth tissues, particularly dental enamel…”
Get more information