Search Results - "Brookes, S"

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells by Lagadinou, Eleni D., Sach, Alexander, Callahan, Kevin, Rossi, Randall M., Neering, Sarah J., Minhajuddin, Mohammad, Ashton, John M., Pei, Shanshan, Grose, Valerie, O’Dwyer, Kristen M., Liesveld, Jane L., Brookes, Paul S., Becker, Michael W., Jordan, Craig T.

“…Most forms of chemotherapy employ mechanisms involving induction of oxidative stress, a strategy that can be effective due to the elevated oxidative state…”
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SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts by Porter, George A, Urciuoli, William R, Brookes, Paul S, Nadtochiy, Sergiy M

“…Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying mechanisms are poorly understood. Age-related damage to mitochondria…”
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In Memoriam: Marcello Costa (1940–2024) – a pioneer of the enteric nervous system by Spencer, N. J., Brookes, S. J. H., Wattchow, D. A.

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Cardioprotection by the mitochondrial unfolded protein response requires ATF5 by Wang, Yves T, Lim, Yunki, McCall, Matthew N, Huang, Kai-Ting, Haynes, Cole M, Nehrke, Keith, Brookes, Paul S

“…The mitochondrial unfolded protein response (UPR ) is a cytoprotective signaling pathway triggered by mitochondrial dysfunction. UPR activation upregulates…”
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Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy by Walters, Andrew M, Porter, George A, Brookes, Paul S

“…Ischemic heart disease is a significant cause of morbidity and mortality in Western society. Although interventions, such as thrombolysis and percutaneous…”
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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS by Chouchani, Edward T., Pell, Victoria R., Gaude, Edoardo, Aksentijević, Dunja, Sundier, Stephanie Y., Robb, Ellen L., Logan, Angela, Nadtochiy, Sergiy M., Ord, Emily N. J., Smith, Anthony C., Eyassu, Filmon, Shirley, Rachel, Hu, Chou-Hui, Dare, Anna J., James, Andrew M., Rogatti, Sebastian, Hartley, Richard C., Eaton, Simon, Costa, Ana S. H., Brookes, Paul S., Davidson, Sean M., Duchen, Michael R., Saeb-Parsy, Kourosh, Shattock, Michael J., Robinson, Alan J., Work, Lorraine M., Frezza, Christian, Krieg, Thomas, Murphy, Michael P.

“…A metabolomics study on the ischaemic heart identifies succinate as a metabolite that drives the production of reactive oxygen species and contributes to…”
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Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity by Zhang, Jimmy, Wang, Yves T., Miller, James H., Day, Mary M., Munger, Joshua C., Brookes, Paul S.

“…Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is…”
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Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses by Hughes, P A, Brierley, S M, Martin, C M, Brookes, S J H, Linden, D R, Blackshaw, L A

“…Intestinal infection evokes hypersensitivity in a subgroup of patients with irritable bowel syndrome (IBS) long after healing of the initial injury…”
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Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling by Nadtochiy, Sergiy M., Schafer, Xenia, Fu, Dragony, Nehrke, Keith, Munger, Joshua, Brookes, Paul S.

“…2-Hydroxyglutarate (2-HG) is an important epigenetic regulator, with potential roles in cancer and stem cell biology. The d-(R)-enantiomer (d-2-HG) is an…”
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Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease by Galloway, Chad A, Lee, Hakjoo, Brookes, Paul S, Yoon, Yisang

“…Mitochondria produce the majority of cellular ATP through oxidative phosphorylation, and their capacity to do so is influenced by many factors. Mitochondrial…”
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Cardiac metabolism as a driver and therapeutic target of myocardial infarction by Zuurbier, Coert J., Bertrand, Luc, Beauloye, Christoph R., Andreadou, Ioanna, Ruiz‐Meana, Marisol, Jespersen, Nichlas R., Kula‐Alwar, Duvaraka, Prag, Hiran A., Eric Botker, Hans, Dambrova, Maija, Montessuit, Christophe, Kaambre, Tuuli, Liepinsh, Edgars, Brookes, Paul S., Krieg, Thomas

“…Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount importance, because the extension of myocardial necrosis is an…”
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What surgeons tell patients and what patients want to know before major cancer surgery: a qualitative study by McNair, Angus G K, MacKichan, F, Donovan, J L, Brookes, S T, Avery, K N L, Griffin, S M, Crosby, T, Blazeby, J M

“…The information surgeons impart to patients and information patients want about surgery for cancer is important but rarely examined. This study explored…”
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Oxygen Sensitivity of Mitochondrial Reactive Oxygen Species Generation Depends on Metabolic Conditions by Hoffman, David L., Brookes, Paul S.

“…The mitochondrial generation of reactive oxygen species (ROS) plays a central role in many cell signaling pathways, but debate still surrounds its regulation…”
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Marcello Costa (1940–2024) by Spencer, N. J., Brookes, S. J., Wattchow, D. A.

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Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high‐resolution fiber‐optic manometry by Dinning, P. G., Wiklendt, L., Maslen, L., Gibbins, I., Patton, V., Arkwright, J. W., Lubowski, D. Z., O'Grady, G., Bampton, P. A., Brookes, S. J., Costa, M.

“…Background Until recently, investigations of the normal patterns of motility of the healthy human colon have been limited by the resolution of in vivo…”
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Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat by Costa, M, Dodds, K N, Wiklendt, L, Spencer, N J, Brookes, S J H, Dinning, P G

“…Gastrointestinal motility involves interactions between myogenic and neurogenic processes intrinsic to the gut wall. We have compared the presence of…”
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Distribution, projections, and association with calbindin baskets of motor neurons, interneurons, and sensory neurons in guinea‐pig distal colon by Smolilo, D. J., Costa, M., Hibberd, T. J., Brookes, S. J. H., Wattchow, D. A., Spencer, N. J.

“…Normal gut function relies on the activity of the enteric nervous system (ENS) found within the wall of the gastrointestinal tract. The structural and…”
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Calcium, ATP, and ROS: a mitochondrial love-hate triangle by Brookes, Paul S, Yoon, Yisang, Robotham, James L, Anders, M W, Sheu, Shey-Shing

“…The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP generation. Calcium is a key regulator of mitochondrial function and…”
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Mitochondrial H + leak and ROS generation: An odd couple by Brookes, Paul S.

“…The single-electron chemistry of mitochondrial oxidative phosphorylation (ox-phos) by default generates reactive oxygen species (ROS). These ROS have roles in…”
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The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function by Bennett, J. Allen, Mastrangelo, Michael A., Ture, Sara K., Smith, Charles O., Loelius, Shannon G., Berg, Rachel A., Shi, Xu, Burke, Ryan M., Spinelli, Sherry L., Cameron, Scott J., Carey, Thomas E., Brookes, Paul S., Gerszten, Robert E., Sabater-Lleal, Maria, de Vries, Paul S., Huffman, Jennifer E., Smith, Nicholas L., Morrell, Craig N., Lowenstein, Charles J.

“…Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may…”
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