Search Results - "Brookes, P A"

TNF Receptors Differentially Signal and Are Differentially Expressed and Regulated in the Human Heart by Al‐Lamki, R. S., Brookes, A. P., Wang, J., Reid, M. J., Parameshwar, J., Goddard, M. J., Tellides, G., Wan, T., Min, W., Pober, J. S., Bradley, J. R.

“…Tumor necrosis factor (TNF) utilizes two receptors, TNFR1 and 2, to initiate target cell responses. We assessed expression of TNF, TNFRs and downstream kinases…”
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Loss of Direct and Maintenance of Indirect Alloresponses in Renal Allograft Recipients: Implications for the Pathogenesis of Chronic Allograft Nephropathy by Baker, Richard J, Hernandez-Fuentes, Maria P, Brookes, Paul A, Chaudhry, Afzal N, Cook, H. Terry, Lechler, Robert I

“…Chronic allograft nephropathy (CAN) is the principal cause of late renal allograft failure. This complex process is multifactorial in origin, and there is good…”
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Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation by Schwarer, A P, Jiang, Y Z, Brookes, P A, Barrett, A J, Batchelor, J R, Goldman, J M, Lechler, R I

“…A substantial proportion of patients undergoing allogeneic bone-marrow transplantation (BMT) develop moderate-to-severe acute graft-versus-host disease (GVHD)…”
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Bone Marrow Transplantation for Chronic Myeloid Leukemia With Volunteer Unrelated Donors Using Ex Vivo or In Vivo T-Cell Depletion: Major Prognostic Impact of HLA Class I Identity Between Donor and Recipient by Spencer, Andrew, Szydlo, Richard M., Brookes, Paul A., Kaminski, Edward, Rule, Simon, Rhee, Frits van, Ward, Katherine N., Hale, Geoff, Waldmann, Herman, Hows, Jill M., Batchelor, J.Richard, Goldman, John M.

“…Between August 1985 and July 1994, we performed 115 volunteer unrelated donor (VUD) bone marrow transplants (BMT) for first chronic phase (n = 86) or advanced…”
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Comparison of the direct and indirect pathways of allorecognition in chronic allograft failure by Baker, R.J., Hernandez-Fuentes, M.P., Brookes, P.A., Chaudhry, A.N., Lechler, R.

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HLA-DPB1 mismatch at position 69 is associated with high helper T lymphocyte precursor frequencies in unrelated bone marrow transplant pairs by POTOLICCHIO, I, BROOKES, P. A, MADRIGAL, A, LECHLER, R. I, SORRENTINO, R

“…HLA incompatibility between bone marrow recipient and unrelated donor pairs is often associated with severe acute graft-versus-host disease following bone…”
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Association between interleukin-4-producing T lymphocyte frequencies and reduced risk of graft-versus-host disease by IMAMI, N, BROOKES, P. A, LOMBARDI, G, HAKOOZ, B, JOHNS, M, GOLDMAN, J. M, BATCHELOR, J. R, LECHLER, R. I, RITTER, M. A

“…We have previously developed and used limiting dilution analysis to measure frequencies of alloreactive cytotoxic T cell precursors (CTLp) and interleukin…”
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Comparison of helper and cytotoxic antirecipient T cell frequencies in unrelated bone marrow transplantation by Schwarer, A P, Jiang, Y Z, Deacock, S, Brookes, P A, Barrett, A J, Goldman, J M, Batchelor, J R, Lechler, R I

“…Donor/recipient histocompatibility antigen differences initiate acute graft-versus-host disease (GVHD) after bone marrow transplantation. Frequency analysis,…”
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Optimizing a limiting dilution culture system for quantifying the frequency of interleukin-2- producing alloreactive T helper lymphocytes by HORNICK, P. I, BROOKES, P. A, MASON, P. D, TAYLOR, K. M, YACOUB, M. H, ROSE, M. L, BATCHELOR, R, LECHLER, R. I

“…The development of sensitive, specific, and reproducible techniques to quantify T cells with direct allospecificity has potential applications in the selection…”
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A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation by BARNARDO, M. C. N. M, DAVEY, N. J, BUNCE, M, BROOKES, P. A, LECHLER, R. I, WELSH, K. I, BATCHELOR, J. R

“…A newly developed, reliable, DNA-based method for typing for alleles of the HLA-C locus has been applied in the context of unrelated, volunteer donors for bone…”
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Cytotoxic T lymphocyte precursor (CTL-p) frequency analysis in unrelated donor bone marrow transplantation: two case studies by Kaminski, E R, Hows, J M, Bridge, J, Davey, N J, Brookes, P A, Green, J E, Goldman, J M, Batchelor, J R

“…HLA 'matched' unrelated donor bone marrow transplantation (BMT) is associated with an increased incidence and severity of acute graft-versus-host disease…”
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The role of the allograft in the induction of donor-specific T cell hyporesponsiveness by BAKER, Richard J, HERNANDEZ-FUENTES, Maria P, BROOKES, Paul A, CHAUDHRY, Afzal N, LECHLER, Robert I

“…With adequate immunosuppression the majority of renal allografts are accepted, despite the exceptional vigour of the T cell alloimmune response. Previous work…”
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In vitro methods and selection of HLA-matched unrelated donors for bone marrow transplantation by Batchelor, J R, Brookes, P A, Davey, N J, Green, J E, Kaminski, E, Bridge, J, Avakian, H, Howell, W M, Sage, D A, Hows, J M

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Preformed complement-activating low-level donor-specific antibody predicts early antibody-mediated rejection in renal allografts by Lawrence, Christopher, Willicombe, Michelle, Brookes, Paul A, Santos-Nunez, Eva, Bajaj, Retesh, Cook, Terry, Roufosse, Candice, Taube, David, Warrens, Anthony N

“…BACKGROUND.: Donor-specific anti-HLA antibodies (DSA) are a major cause of alloimmune injury. Transplant recipients with negative complement-dependent…”
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Field observations on the longevity of Trichuris suis ova by Burden, D J, Hammet, N C, Brookes, P A

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Application of an automated enzymatic technique for the determination of non-esterified fatty acids in bovine blood by Brookes, P A, Dew, A M, Pike, B V, Roberts, C J

“…An enzymatic method for the measurement of non-esterified fatty acid (NEFA) concentrations in blood was applied to samples from dairy cows. The method was…”
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Peritubular Capillary Basement Membrane Multilayering on Electron Microscopy: A Useful Marker of Early Chronic Antibody-Mediated Damage by ROUFOSSE, Candice A, SHORE, Ian, TAUBE, David, TERENCE COOK, H, MOSS, Jill, MORAN, Linda B, WILLICOMBE, Michelle, GALLIFORD, Jack, CHAN, Ka-Kit K, BROOKES, Paul A, DE KORT, Hanneke, MCLEAN, Adam G

“…Chronic antibody-mediated rejection is an important cause of late graft failure. Developing an early marker of the disease may allow diagnosis and treatment…”
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IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation by Jordan, William J., Brookes, Paul A., Szydlo, Richard M., Goldman, John M., Lechler, Robert I., Ritter, Mary A.

“…Despite the success of human leukocyte antigen (HLA) typing in allogeneic stem cell transplantation (SCT) it is rare to find an unrelated donor that is…”
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Cytotoxic T lymphocyte precursor frequency analyses in bone marrow transplantation with volunteer unrelated donors. Value in donor selection by Spencer, A, Brookes, P A, Kaminski, E, Hows, J M, Szydlo, R M, van Rhee, F, Goldman, J M, Batchelor, J R

“…Between May 1989 and February 1994, we performed 48 volunteer unrelated donor BMTs for first chronic phase chronic myeloid leukemia using in vivo T cell…”
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Astronomy in the Ancient World by Brookes, A. M. P.

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