Search Results - "Brook, C G D"

Failure of IGF-I and IGFBP-3 to diagnose growth hormone insufficiency by Mitchell, H, Dattani, M T, Nanduri, V, Hindmarsh, P C, Preece, M A, Brook, C G D

“…BACKGROUND Growth hormone insufficiency (GHI) is diagnosed conventionally by short stature and slow growth, and is confirmed by diminished peak GH response to…”
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Frasier syndrome, part of the Denys Drash continuum or simply a WT1 gene associated disorder of intersex and nephropathy? by Koziell, A., Charmandari, E., Hindmarsh, P. C., Rees, L., Scambler, P., Brook, C. G. D.

“…Summary Dysfunction of the Wilms’Tumour gene (WT1), a transcription factor critical for normal development and function of the urogenital tract, can result in…”
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Congenital adrenal hyperplasia: management during critical illness by Charmandari, E, Lichtarowicz-Krynska, E J, Hindmarsh, P C, Johnston, A, Aynsley-Green, A, Brook, C G D

“…BACKGROUND Little is known of the optimal dose and administration schedule of hydrocortisone in critically ill patients with congenital adrenal hyperplasia…”
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The use of low doses of ACTH in the investigation of adrenal function in man by Crowley, S, Hindmarsh, P C, Holownia, P, Honour, J W, Brook, C G

“…We have investigated the adrenal response, in eight healthy adult men, to low doses of ACTH(1-24) in order to define a dose which will elicit a response…”
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Evolution of growth hormone neurosecretory disturbance after cranial irradiation for childhood brain tumours: a prospective study by Spoudeas, H A, Hindmarsh, P C, Matthews, D R, Brook, C G

“…To determine the aetiopathology of post-irradiation growth hormone (GH) deficiency, we performed a mixed longitudinal analysis of 56 24 h serum GH…”
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Reproducibility of the cortisol response to stimulation with a low dose of ACTH(1-24): the effect of basal cortisol levels and comparison of low-dose with high-dose secretory dynamics by Crowley, S, Hindmarsh, P C, Honour, J W, Brook, C G

“…We compared the reproducibility and repeatability of the acute adrenal response to low doses (90 and 500 ng/1.73 m2) of Synacthen (ACTH(1-24)) with that of the…”
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Peak and trough growth hormone (GH) concentrations influence growth and serum insulin like growth factor-1 (IGF-1) concentrations in short children by Achermann, J. C., Brook, C. G. D., Robinson, I. C. A. F., Matthews, D. R., Hindmarsh, P. C.

“…Summary OBJECTIVE Growth hormone (GH) is secreted in a pulsatile fashion promoting growth and a number of diverse metabolic actions. The precise components of…”
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Growth hormone increases rate of pubertal maturation by Darendeliler, F, Hindmarsh, P C, Preece, M A, Cox, L, Brook, C G

“…We have performed a retrospective analysis of the pubertal parameters of 134 children with isolated GH insufficiency on GH treatment and compared them to the…”
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A randomised study of two doses of biosynthetic human growth hormone on final height of pubertal children with growth hormone deficiency by Coelho, R, Brook, C G D, Preece, M A, Stanhope, R G, Dattani, M T, Hindmarsh, P C

“…To determine the effectiveness of different doses of r-hGH therapy during puberty in children with growth hormone deficiency (GHD). Randomized controlled trial…”
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Blood pressure and Turner syndrome by NATHWANI, N. C, UNWIN, R, BROOK, C. G. D, HINDMARSH, P. C

“…INTRODUCTION Elevated blood pressure (BP) is an important predictor of morbidity and mortality from cardiovascular disease. Patients with Turner syndrome (TS)…”
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Factors involved in the rate of fall of thyroid stimulating hormone in treated hypothyroidism by Raza, J, Hindmarsh, P C, Brook, C G D

“…The rate of fall of serum thyroid stimulating hormone (TSH) concentrations in 32 hypothyroid infants (11 boys, 21 girls) was studied after starting treatment…”
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The influence of renal and cardiovascular abnormalities on blood pressure in Turner syndrome by NATHWANI, N. C, UNWIN, R, BROOK, C. G. D, HINDMARSH, P. C

“…INTRODUCTION Patients with Turner syndrome (TS) are at an increased risk of morbidity and mortality from cardiovascular disease. This study was undertaken to…”
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Tests of adrenal insufficiency by Agwu, J C, Spoudeas, H, Hindmarsh, P C, Pringle, P J, Brook, C G D

“…AIM In suspected adrenal insufficiency, the ideal test for assessing the hypothalamo–pituitary–adrenal axis is controversial. Therefore, three tests were…”
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What is a normal stimulated growth hormone concentration? by Dattani, M T, Pringle, P J, Hindmarsh, P C, Brook, C G

“…In a retrospective analysis, we have compared the response of serum GH concentration to insulin-induced hypoglycaemia in 148 short prepubertal children (114…”
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Inhibition of growth hormone bioactivity by recombinant human growth hormone-binding protein in the eluted stain assay system by Dattani, M T, Hindmarsh, P C, Brook, C G, Robinson, I C, Marshall, N J

“…The effects of a recombinant human GH-binding protein (rhGHBP; amino acids 1-238) on GH stimulation of rat Nb2 lymphoma cells were examined with an eluted…”
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A randomised study of the effect of two doses of biosynthetic human growth hormone on final height of children with familial short stature by Elder, C J, Barton, J S, Brook, C G D, Preece, M A, Dattani, M T, Hindmarsh, P C

“…The effects of biosynthetic human growth hormone (r-hGH) in children with familial short stature (FSS) are varied. We determined whether responsivity to r-hGH…”
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Changes in gonadotrophin secretion during childhood and puberty by Bridges, N A, Matthews, D R, Hindmarsh, P C, Brook, C G

“…The changes in gonadotrophin secretion in childhood and puberty involve changes in the pulsatile pattern as well as mean concentration. We have examined…”
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A Sexually Dimorphic Pattern of Growth Hormone Secretion in the Elderly by Hindmarsh, P. C, Dennison, E, Pincus, S. M, Cooper, C, Fall, C. H. D, Matthews, D. R, Pringle, P. J, Brook, C. G. D

“…In rodents, the sexually dimorphic pattern of pulsatile GH secretion is an important determinant of growth, liver enzyme function and insulin-like growth…”
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Dose-response curves for treatment with biosynthetic human growth hormone by Darendeliler, F, Hindmarsh, P C, Brook, C G

“…We have studied the effect of varying doses of biosynthetic human GH on the growth response over the first year of therapy in 90 short prepubertal children (67…”
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Short-term endocrine consequences of total body irradiation and bone marrow transplantation in children treated for leukemia by Ryalls, M, Spoudeas, H A, Hindmarsh, P C, Matthews, D R, Tait, D M, Meller, S T, Brook, C G

“…We studied 24-h hormone profiles and hormonal responses to insulin-induced hypoglycaemia prospectively in 23 children of similar age and pubertal stage, nine…”
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