Search Results - "Brooijmans, N"

O048 : First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway by Hoeflich, K, Hagel, M, Miduturu, C, Sheets, M, Rubin, N, Weng, W, Stransky, N, Bifulco, N, Kim, J, Hodous, B, Brooijmans, N, Shutes, A, Winter, C, Lengauer, C, Kohl, N, Guzi, T

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Principles and methods of docking and ligand design by Krumrine, J, Raubacher, F, Brooijmans, N, Kuntz, I

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Identification of STX-721, an EGFR exon 20 mutant inhibitor with superior selectivity and a potential best-in-class profile by Pagliarini, R., Milgram, B.C., Borrelli, D.R., Brooijmans, N., Huff, M.R., Ito, T., Jonsson, P., Ladd, B., O’Hearn, E., Wang, W., Kuzmic, P., Bellier, J., Hata, A.N., Guzman-Perez, A., Stuart, D.D.

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Stability of macromolecular complexes by Brooijmans, Natasja, Sharp, Kim A., Kuntz, Irwin D.

“…Macromolecular interactions are crucial in numerous biologic processes, yet few general principles are available that establish firm expectations for the…”
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Structure-based optimization of PKCtheta inhibitors by Mosyak, L, Xu, Z, Joseph-McCarthy, D, Brooijmans, N, Somers, W, Chaudhary, D

“…PKCtheta (protein kinase Ctheta) is a central signalling molecule in the T-cell receptor activation pathway and is a target for treatment of a number of…”
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The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel by Wilson, G G, Pascual, J M, Brooijmans, N, Murray, D, Karlin, A

“…A ring of aligned glutamate residues named the intermediate ring of charge surrounds the intracellular end of the acetylcholine receptor channel and dominates…”
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MOLECULAR RECOGNITION AND DOCKING ALGORITHMS by Brooijmans, Natasja, Kuntz, Irwin D

“…Molecular docking is an invaluable tool in modern drug discovery. This review focuses on methodological developments relevant to the field of molecular…”
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