Search Results - "Bromley, Michael"

How to bolster the antifungal pipeline by Denning, David W, Bromley, Michael J

“…Few drugs are coming to market, but opportunities for drug development exist About 1.2 billion people worldwide are estimated to suffer from a fungal disease (…”
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Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex by Gsaller, Fabio, Hortschansky, Peter, Furukawa, Takanori, Carr, Paul D, Rash, Bharat, Capilla, Javier, Müller, Christoph, Bracher, Franz, Bowyer, Paul, Haas, Hubertus, Brakhage, Axel A, Bromley, Michael J

“…Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs,…”
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The Consequences of Our Changing Environment on Life Threatening and Debilitating Fungal Diseases in Humans by van Rhijn, Norman, Bromley, Michael

“…Human activities have significantly impacted the environment and are changing our climate in ways that will have major consequences for ourselves, and endanger…”
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The C2H2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatus by Du, Wenlong, Zhai, Pengfei, Wang, Tingli, Bromley, Michael J, Zhang, Yuanwei, Lu, Ling

“…The emergence of azole-resistant fungal pathogens has posed a great threat to public health worldwide. Although the molecular mechanism of azole resistance has…”
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Tackling the emerging threat of antifungal resistance to human health by Fisher, Matthew C., Alastruey-Izquierdo, Ana, Berman, Judith, Bicanic, Tihana, Bignell, Elaine M., Bowyer, Paul, Bromley, Michael, Brüggemann, Roger, Garber, Gary, Cornely, Oliver A., Gurr, Sarah. J., Harrison, Thomas S., Kuijper, Ed, Rhodes, Johanna, Sheppard, Donald C., Warris, Adilia, White, P. Lewis, Xu, Jianping, Zwaan, Bas, Verweij, Paul E.

“…Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis…”
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Pathogenicity and virulence of Aspergillus fumigatus by Earle, Kayleigh, Valero, Clara, Conn, Daniel P., Vere, George, Cook, Peter C., Bromley, Michael J., Bowyer, Paul, Gago, Sara

“…Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major cause of morbidity and mortality globally. Compromised lung defences…”
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On the lineage of Aspergillus fumigatus isolates in common laboratory use by Bertuzzi, Margherita, van Rhijn, Norman, Krappmann, Sven, Bowyer, Paul, Bromley, Michael J, Bignell, Elaine M

“…Abstract The origin of isolates routinely used by the community of Aspergillus fumigatus researchers is periodically a matter of intense discussion at our…”
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Bose-Einstein condensation in large time-averaged optical ring potentials by Bell, Thomas A, Glidden, Jake A P, Humbert, Leif, Bromley, Michael W J, Haine, Simon A, Davis, Matthew J, Neely, Tyler W, Baker, Mark A, Rubinsztein-Dunlop, Halina

“…Interferometric measurements with matter waves are established techniques for sensitive gravimetry, rotation sensing, and measurement of surface interactions,…”
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Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression by Beattie, Sarah R, Mark, Kenneth M K, Thammahong, Arsa, Ries, Laure Nicolas Annick, Dhingra, Sourabh, Caffrey-Carr, Alayna K, Cheng, Chao, Black, Candice C, Bowyer, Paul, Bromley, Michael J, Obar, Joshua J, Goldman, Gustavo H, Cramer, Robert A

“…Aspergillus fumigatus is responsible for a disproportionate number of invasive mycosis cases relative to other common filamentous fungi. While many fungal…”
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The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus by Furukawa, Takanori, van Rhijn, Norman, Fraczek, Marcin, Gsaller, Fabio, Davies, Emma, Carr, Paul, Gago, Sara, Fortune-Grant, Rachael, Rahman, Sayema, Gilsenan, Jane Mabey, Houlder, Emma, Kowalski, Caitlin H., Raj, Shriya, Paul, Sanjoy, Cook, Peter, Parker, Josie E., Kelly, Steve, Cramer, Robert A., Latgé, Jean-Paul, Moye-Rowley, Scott, Bignell, Elaine, Bowyer, Paul, Bromley, Michael J.

“…The frequency of antifungal resistance, particularly to the azole class of ergosterol biosynthetic inhibitors, is a growing global health problem. Survival…”
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F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase by Oliver, Jason D., Sibley, Graham E. M., Beckmann, Nicola, Dobb, Katharine S., Slater, Martin J., McEntee, Laura, du Pré, Saskia, Livermore, Joanne, Bromley, Michael J., Wiederhold, Nathan P., Hope, William W., Kennedy, Anthony J., Law, Derek, Birch, Mike

“…There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening…”
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Determining Aspergillus fumigatus transcription factor expression and function during invasion of the mammalian lung by Liu, Hong, Xu, Wenjie, Bruno, Vincent M, Phan, Quynh T, Solis, Norma V, Woolford, Carol A, Ehrlich, Rachel L, Shetty, Amol C, McCraken, Carrie, Lin, Jianfeng, Bromley, Michael J, Mitchell, Aaron P, Filler, Scott G

“…To gain a better understanding of the transcriptional response of Aspergillus fumigatus during invasive pulmonary infection, we used a NanoString nCounter to…”
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The C 2 H 2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatus by Du, Wenlong, Zhai, Pengfei, Wang, Tingli, Bromley, Michael J, Zhang, Yuanwei, Lu, Ling

“…The emergence of azole-resistant fungal pathogens has posed a great threat to public health worldwide. Although the molecular mechanism of azole resistance has…”
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Rational Design of Phe‐BODIPY Amino Acids as Fluorogenic Building Blocks for Peptide‐Based Detection of Urinary Tract Candida Infections by Mendive‐Tapia, Lorena, Mendive‐Tapia, David, Zhao, Can, Gordon, Doireann, Benson, Sam, Bromley, Michael J., Wang, Wei, Wu, Jun, Kopp, Adelina, Ackermann, Lutz, Vendrell, Marc

“…Fungal infections caused by Candida species are among the most prevalent in hospitalized patients. However, current methods for the detection of Candida fungal…”
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Development of a marker-free mutagenesis system using CRISPR-Cas9 in the pathogenic mould Aspergillus fumigatus by van Rhijn, Norman, Furukawa, Takanori, Zhao, Can, McCann, Bethany L., Bignell, Elaine, Bromley, Michael J.

“…•In vitro assembled CRISPR/Cas9-gRNA complexes can mediate selection free transformation.•Single gRNAs can be used to target mutagenesis effectively.•Targeted…”
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Linking calcium signaling and mitochondrial function in fungal drug resistance by Bowyer, Paul, Bromley, Michael J., Denning, David W.

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The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition by Furukawa, Takanori, Scheven, Mareike Thea, Misslinger, Matthias, Zhao, Can, Hoefgen, Sandra, Gsaller, Fabio, Lau, Jeffrey, Jöchl, Christoph, Donaldson, Ian, Valiante, Vito, Brakhage, Axel A, Bromley, Michael J, Haas, Hubertus, Hortschansky, Peter

“…Abstract To sustain iron homeostasis, microorganisms have evolved fine-tuned mechanisms for uptake, storage and detoxification of the essential metal iron. In…”
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Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus by Gsaller, Fabio, Furukawa, Takanori, Carr, Paul D, Rash, Bharat, Jöchl, Christoph, Bertuzzi, Margherita, Bignell, Elaine M, Bromley, Michael J

“…The antifungal drug 5-flucytosine (5FC), a derivative of the nucleobase cytosine, is licensed for the treatment of fungal diseases; however, it is rarely used…”
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Author Correction: Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging by van Rhijn, Norman, Zhao, Can, Al-Furaiji, Narjes, Storer, Isabelle S. R., Valero, Clara, Gago, Sara, Chown, Harry, Baldin, Clara, Grant, Rachael-Fortune, Bin Shuraym, Hajer, Ivanova, Lia, Kniemeyer, Olaf, Krüger, Thomas, Bignell, Elaine, Goldman, Gustavo H., Amich, Jorge, Delneri, Daniela, Bowyer, Paul, Brakhage, Axel A., Haas, Hubertus, Bromley, Michael J.

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Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging by van Rhijn, Norman, Zhao, Can, Al-Furaiji, Narjes, Storer, Isabelle S. R., Valero, Clara, Gago, Sara, Chown, Harry, Baldin, Clara, Grant, Rachael-Fortune, Bin Shuraym, Hajer, Ivanova, Lia, Kniemeyer, Olaf, Krüger, Thomas, Bignell, Elaine, Goldman, Gustavo H., Amich, Jorge, Delneri, Daniela, Bowyer, Paul, Brakhage, Axel A., Haas, Hubertus, Bromley, Michael J.

“…More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus . Azole antifungals represent first-line…”
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