Search Results - "Brombacher, Frank"

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch by Oetjen, Landon K., Mack, Madison R., Feng, Jing, Whelan, Timothy M., Niu, Haixia, Guo, Changxiong J., Chen, Sisi, Trier, Anna M., Xu, Amy Z., Tripathi, Shivani V., Luo, Jialie, Gao, Xiaofei, Yang, Lihua, Hamilton, Samantha L., Wang, Peter L., Brestoff, Jonathan R., Council, M. Laurin, Brasington, Richard, Schaffer, András, Brombacher, Frank, Hsieh, Chyi-Song, Gereau, Robert W., Miller, Mark J., Chen, Zhou-Feng, Hu, Hongzhen, Davidson, Steve, Liu, Qin, Kim, Brian S.

“…Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to expel invading pathogens and noxious environmental stimuli. It is well…”
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Host Regulators of Liver Fibrosis During Human Schistosomiasis by Kamdem, Severin Donald, Moyou-Somo, Roger, Brombacher, Frank, Nono, Justin Komguep

“…Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or…”
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Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion by Leyva-Castillo, Juan-Manuel, Galand, Claire, Kam, Christy, Burton, Oliver, Gurish, Michael, Musser, Melissa A., Goldsmith, Jeffrey D., Hait, Elizabeth, Nurko, Samuel, Brombacher, Frank, Dong, Chen, Finkelman, Fred D., Lee, Richard T., Ziegler, Steven, Chiu, Isaac, Austen, K. Frank, Geha, Raif S.

“…Mast cell (MC) mediator release after crosslinking of surface-bound IgE antibody by ingested antigen underlies food allergy. However, IgE antibodies are not…”
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IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1 by Jenkins, Stephen J, Ruckerl, Dominik, Thomas, Graham D, Hewitson, James P, Duncan, Sheelagh, Brombacher, Frank, Maizels, Rick M, Hume, David A, Allen, Judith E

“…Macrophages (MΦs) colonize tissues during inflammation in two distinct ways: recruitment of monocyte precursors and proliferation of resident cells. We…”
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Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis by Hurdayal, Ramona, Brombacher, Frank

“…The interleukin (IL)-4 receptor alpha (IL-4Rα), ubiquitously expressed on both innate and adaptive immune cells, controls the signaling of archetypal type 2…”
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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis by Nguyen, Khoa D., Qiu, Yifu, Cui, Xiaojin, Goh, Y. P. Sharon, Mwangi, Julia, David, Tovo, Mukundan, Lata, Brombacher, Frank, Locksley, Richard M., Chawla, Ajay

“…Exposure to cold drives IL-4-mediated alternative macrophage activation and catecholamine secretion in brown and white adipose tissues to stimulate…”
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Environment and Host-Genetic Determinants in Early Development of Allergic Asthma: Contribution of Fungi by Hadebe, Sabelo, Brombacher, Frank

“…Asthma is a chronic debilitating airway disease affecting millions of people worldwide. Although largely thought to be a disease of the first world, it is now…”
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IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis by Scibiorek, Martyna, Mthembu, Nontobeko, Mangali, Sandisiwe, Ngomti, Amkele, Ikwegbue, Paul, Brombacher, Frank, Hadebe, Sabelo

“…Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposing factors. Primary skin barrier…”
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IL-13-Mediated Regulation of Learning and Memory by Brombacher, Tiroyaone M, Nono, Justin K, De Gouveia, Keisha S, Makena, Nokuthula, Darby, Matthew, Womersley, Jacqueline, Tamgue, Ousman, Brombacher, Frank

“…The role of proinflammatory cytokines in cognitive function has been investigated with both beneficial and possible detrimental effects, depending on the…”
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Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model by Miyake, Kensuke, Ito, Junya, Takahashi, Kazufusa, Nakabayashi, Jun, Brombacher, Frank, Shichino, Shigeyuki, Yoshikawa, Soichiro, Miyake, Sachiko, Karasuyama, Hajime

“…Both monocytes and macrophages are heterogeneous populations. It was traditionally understood that Ly6C hi classical (inflammatory) monocytes differentiate…”
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Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation by Davies, Luke C., Rosas, Marcela, Jenkins, Stephen J., Liao, Chia-Te, Scurr, Martin J., Brombacher, Frank, Fraser, Donald J., Allen, Judith E., Jones, Simon A., Taylor, Philip R.

“…The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of…”
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The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections by Abdel Aziz, Nada, Nono, Justin Komguep, Mpotje, Thabo, Brombacher, Frank

“…Forkhead box P3 (Foxp3+) regulatory T (Treg)-cell function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. In…”
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Author Correction: IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis by Scibiorek, Martyna, Mthembu, Nontobeko, Mangali, Sandisiwe, Ngomti, Amkele, Ikwegbue, Paul, Brombacher, Frank, Hadebe, Sabelo

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Immunoglobulin M in Health and Diseases: How Far Have We Come and What Next? by Jones, Katelyn, Savulescu, Anca F, Brombacher, Frank, Hadebe, Sabelo

“…B lymphocytes are important in secreting antibodies that protect against invading pathogens such as viruses, bacteria, parasites, and also in mediating…”
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Triptolide Modulates the Expression of Inflammation-Associated lncRNA-PACER and lincRNA-p21 in Mycobacterium tuberculosis -Infected Monocyte-Derived Macrophages by Tamgue, Ousman, Chia, Julius Ebua, Brombacher, Frank

“…Triptolide is a diterpene triepoxide, which performs its biological activities mechanisms including induction of apoptosis, targeting of pro-inflammatory…”
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Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization by Mayer, Johannes U., Hilligan, Kerry L., Chandler, Jodie S., Eccles, David A., Old, Samuel I., Domingues, Rita G., Yang, Jianping, Webb, Greta R., Munoz-Erazo, Luis, Hyde, Evelyn J., Wakelin, Kirsty A., Tang, Shiau-Choot, Chappell, Sally C., von Daake, Sventja, Brombacher, Frank, Mackay, Charles R., Sher, Alan, Tussiwand, Roxane, Connor, Lisa M., Gallego-Ortega, David, Jankovic, Dragana, Le Gros, Graham, Hepworth, Matthew R., Lamiable, Olivier, Ronchese, Franca

“…The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of…”
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IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate by Noviski, Mark, Mueller, James L, Satterthwaite, Anne, Garrett-Sinha, Lee Ann, Brombacher, Frank, Zikherman, Julie

“…Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated…”
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Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection by Rolot, Marion, Dougall, Annette M., Chetty, Alisha, Javaux, Justine, Chen, Ting, Xiao, Xue, Machiels, Bénédicte, Selkirk, Murray E., Maizels, Rick M., Hokke, Cornelis, Denis, Olivier, Brombacher, Frank, Vanderplasschen, Alain, Gillet, Laurent, Horsnell, William G. C., Dewals, Benjamin G.

“…Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8 + T cells (T VM…”
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C-Type Lectin Receptors in Asthma by Hadebe, Sabelo, Brombacher, Frank, Brown, Gordon D

“…Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The etiology of the disease is…”
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Environmental and microbial factors influence affective and cognitive behavior in C57BL/6 sub-strains by Abdel Aziz, Nada, Berkiks, Inssaf, Mosala, Paballo, Brombacher, Tiroyaone M, Brombacher, Frank

“…C57BL/6 mice are one of the most widely used inbred strains in biomedical research. Early separation of the breeding colony has led to the development of…”
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