Search Results - "Broholm, H"

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas by Bartkova, J, Hamerlik, P, Stockhausen, M-T, Ehrmann, J, Hlobilkova, A, Laursen, H, Kalita, O, Kolar, Z, Poulsen, H S, Broholm, H, Lukas, J, Bartek, J

“…Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant…”
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Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers by Muhic, Aida, Broholm, H., Hauerberg, J., Capion, T.

“…Gliosarcoma (GS) constitutes a minor fraction of primary glioblastoma (GBM), which is the most frequent malignant brain tumor in adults. Despite the fact that…”
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Effect of nitric oxide on spinal evoked potentials and survival rate in rats with decompression sickness by Randsoe, T, Meehan, C F, Broholm, H, Hyldegaard, O

“…Nitric oxide (NO) releasing agents have, in experimental settings, been shown to decrease intravascular nitrogen bubble formation and to increase the survival…”
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Pathophysiology of shunt dysfunction in shunt treated hydrocephalus by Blegvad, C., Skjolding, A. D., Broholm, H., Laursen, H., Juhler, M.

“…Background We hypothesized that shunt dysfunction in the ventricular catheter and the shunt valve is caused by different cellular responses. We also…”
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Differences in distribution and regulation of astrocytic aquaporin-4 in human and rat hydrocephalic brain by Skjolding, A. D., Holst, A. V., Broholm, H., Laursen, H., Juhler, M.

“…A. D. Skjolding, A. V. Holst, H. Broholm, H. Laursen and M. Juhler (2013) Neuropathology and Applied Neurobiology39, 179–191 Differences in distribution and…”
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Vascular endothelial growth factor (VEGF) receptor neuropilin-1's distribution in astrocytic tumors by BROHOLM, H., LAURSEN, H.

“…Neuropilin‐1 is a VEGF165‐ and semaphorin receptor expressed by endothelial cells and tumor cells. The specific function of neuropilin‐1 is not fully known,…”
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Targeted gene-expression analysis during malignant transformation in primary and secondary malignant meningioma by Maier, A.D., Meddis, A., Haslund-Vinding, J., Mirian, C., Areskeviciute, A., Nguyen, P., Westergaard, C., Melchior, L.C., Munch, T.N., Skjøth-Rasmussen, J., Poulsgaard, L., Ziebell, M., Bartek, J., Broholm, H., Poulsen, F.R., Gerds, T.A., Scheie, D., Mathiesen, T.

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P17.91 CLINICAL VARIABLES SERVE AS PREDICTIVE FACTORS IN A MODEL FOR CLINICAL RESPONSE TO BEVACIZUMAB IN RECURRENT GLIOBLASTOMA MULTIFORME: AN OBSERVATIONAL STUDY OF A COHORT OF CONSECUTIVE NON-SELECTED PATIENTS FROM A SINGLE INSTITUTION by Urup, T., Grunnet, K., Christensen, I. J., Michaelsen, S. R., Broholm, H., Stockhausen, M. T., Lassen, U., Poulsen, H. S.

“…Bevacizumab (BEV), a humanized monoclonal antibody against vascular endothelial growth factor A, has demonstrated activity in patients with recurrent…”
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Genetic variations in VEGF and VEGFR2 and glioblastoma outcome by Sjöström, S., Wibom, C., Andersson, U., Brännström, T., Broholm, H., Johansen, C., Collatz-Laier, H., Liu, Y., Bondy, M., Henriksson, R., Melin, B.

“…Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate…”
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Risk factors for oligodendroglial tumors: A pooled international study by McCarthy, Bridget J., Rankin, Kristin M., Aldape, Ken, Bondy, Melissa L., Brännström, Thomas, Broholm, Helle, Feychting, Maria, Il'yasova, Dora, Inskip, Peter D., Johansen, Christoffer, Melin, Beatrice S., Ruder, Avima M., Butler, Mary Ann, Scheurer, Michael E., Schüz, Joachim, Schwartzbaum, Judith A., Wrensch, Margaret R., Davis, Faith G.

“…Oligodendroglial tumors are rare subtypes of brain tumors and are often combined with other glial tumors in epidemiological analyses. However, different…”
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Nitric oxide synthase expression and enzymatic activity in multiple sclerosis by Broholm, H., Andersen, B., Wanscher, B., Frederiksen, J. L., Rubin, I., Pakkenberg, B., Larsson, H. B. W., Lauritzen, M.

“…We used post‐mortem magnetic resonance imaging (MRI) guidance to obtain paired biopsies from the brains of four patients with clinical definite multiple…”
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Detecting chromosomal alterations at 1p and 19q by FISH and DNA fragment analysis--a comparative study in human gliomas by Broholm, H, Born, P W, Guterbaum, D, Dyrbye, H, Laursen, H

“…Histological classification of gliomas is important for treatment and as a prognostic predictor, but classification by histology alone can be a challenge…”
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Nitric oxide synthase expression and enzymatic activity in human brain tumors by Broholm, H, Rubin, I, Kruse, A, Braendstrup, O, Schmidt, K, Skriver, E B, Lauritzen, M

“…Nitric oxide (NO) is synthesized by NO synthases (NOS), existing in 3 isoforms. NO influences a great variety of vital functions including vascular tone and…”
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Nitric oxide synthase activity in human pituitary adenomas by Kruse, A., Broholm, H., Rubin, I., Schmidt, K., Lauritzen, M.

“…Objectives – The purpose of the present study was to examine human pituitary adenomas for nitric oxide synthase (NOS) activity by immunohistochemical and…”
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Papillary glioneuronal tumor--a new tumor entity by Broholm, H, Madsen, F F, Wagner, A A, Laursen, H

“…Glioneuronal neoplasms of the CNS comprises a heterogeneous group of generally low-grade tumors expressing glial and neuronal cells of varying differentiation…”
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Tracheobronchopathia osteochondroplastica by Meyer, C.N., Døssing, M., Broholm, H.

“…A case of tracheobronchopathia osteochondroplastica (TO) was diagnosed in a 68-year-old male with prolonged cough. A bronchoscopy revealed multiple nodular…”
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Poor prognosis associated with TERT gene alterations in meningioma is independent of the WHO classification: an individual patient data meta-analysis by Mirian, Christian, Duun-Henriksen, Anne Katrine, Juratli, Tareq, Sahm, Felix, Spiegl-Kreinecker, Sabine, Peyre, Matthieu, Biczok, Annamaria, Tonn, Jörg-Christian, Goutagny, Stéphane, Bertero, Luca, Maier, Andrea Daniela, Møller Pedersen, Maria, Law, Ian, Broholm, Helle, Cahill, Daniel P., Brastianos, Priscilla, Poulsgaard, Lars, Fugleholm, Kåre, Ziebell, Morten, Munch, Tina, Mathiesen, Tiit

“…Background TERT gene alterations (TERT-alt) have been linked to increased risk of recurrence in meningiomas, whereas the association to mortality largely…”
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Nitric oxide synthase expression of oligodendrogliomas by Broholm, H, Braendstrup, O, Lauritzen, M

“…In the central nervous system, nitric oxide (NO) has a variety of biological functions including vasorelaxation and neurotransmission. The synthesis of NO is…”
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Somatostatin Receptor-Targeted Radiopeptide Therapy in Treatment-Refractory Meningioma: Individual Patient Data Meta-analysis by Mirian, Christian, Duun-Henriksen, Anne Katrine, Maier, Andrea, Pedersen, Maria Møller, Jensen, Lasse Rehné, Bashir, Asma, Graillon, Thomas, Hrachova, Maya, Bota, Daniela, van Essen, Martjin, Spanjol, Petar, Kreis, Christian, Law, Ian, Broholm, Helle, Poulsgaard, Lars, Fugleholm, Kåre, Ziebell, Morten, Munch, Tina, Walter, Martin A, Mathiesen, Tiit

“…Somatostatin receptor (SSTR)-targeted peptide receptor radionuclide therapy (PRRT) represents a promising approach for treatment-refractory meningiomas. We…”
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TERT promoter mutations in primary and secondary WHO grade III meningioma by Maier, Andrea Daniela, Stenman, Adam, Svahn, Fredrika, Mirian, Christian, Bartek, Jiri, Juhler, Marianne, Zedenius, Jan, Broholm, Helle, Mathiesen, Tiit

“…Purpose: TERT promoter mutation (TERTpMut) has a strong association to recurrence and has been suggested to act as a driver mutation for malignant…”
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