Search Results - "Brognara, Eleonora"

Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review) by GAMBARI, ROBERTO, BROGNARA, ELEONORA, SPANDIDOS, DEMETRIOS A, FABBRI, ENRICA

“…MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking miRNAs involved in cancer onset, progression, angiogenesis,…”
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Combined Delivery of Temozolomide and Anti-miR221 PNA Using Mesoporous Silica Nanoparticles Induces Apoptosis in Resistant Glioma Cells by Bertucci, Alessandro, Prasetyanto, Eko Adi, Septiadi, Dedy, Manicardi, Alex, Brognara, Eleonora, Gambari, Roberto, Corradini, Roberto, De Cola, Luisa

“…Mesoporous silica nanoparticles (MSNPs), 100 nm in size, incorporating a Cy5 fluorophore within the silica framework, are synthesized and loaded with the…”
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Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development by Gambari, Roberto, Fabbri, Enrica, Borgatti, Monica, Lampronti, Ilaria, Finotti, Alessia, Brognara, Eleonora, Bianchi, Nicoletta, Manicardi, Alex, Marchelli, Rosangela, Corradini, Roberto

“…MicroRNAs regulate gene expression and anti-sense microRNA molecules and microRNA mimics are proposed in diagnostics and therapy. Peptide nucleic acids (PNAs)…”
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High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222 by BROGNARA, ELEONORA, FABBRI, ENRICA, MONTAGNER, GIULIA, GASPARELLO, JESSICA, MANICARDI, ALEX, CORRADINI, ROBERTO, BIANCHI, NICOLETTA, FINOTTI, ALESSIA, BREVEGLIERI, GIULIA, BORGATTI, MONICA, LAMPRONTI, ILARIA, MILANI, ROBERTA, DECHECCHI, MARIA CRISTINA, CABRINI, GIULIO, GAMBARI, ROBERTO

“…The biological activity of a combined treatment of U251, U373 and T98G glioma cell lines with two anti-miR PNAs, directed against miR-221 and miR-222 and…”
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Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221 by Brognara, Eleonora, Fabbri, Enrica, Bazzoli, Elena, Montagner, Giulia, Ghimenton, Claudio, Eccher, Albino, Cantù, Cinzia, Manicardi, Alex, Bianchi, Nicoletta, Finotti, Alessia, Breveglieri, Giulia, Borgatti, Monica, Corradini, Roberto, Bezzerri, Valentino, Cabrini, Giulio, Gambari, Roberto

“…MicroRNAs are a family of small noncoding RNAs regulating gene expression by sequence-selective mRNA targeting, leading to a translational repression or mRNA…”
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Cellular Uptakes, Biostabilities and Anti-miR-210 Activities of Chiral Arginine-PNAs in Leukaemic K562 Cells by Manicardi, Alex, Fabbri, Enrica, Tedeschi, Tullia, Sforza, Stefano, Bianchi, Nicoletta, Brognara, Eleonora, Gambari, Roberto, Marchelli, Rosangela, Corradini, Roberto

“…A series of 18‐mer peptide nucleic acids (PNAs) targeted against micro‐RNA miR‐210 was synthesised and tested in a cellular system. Unmodified PNAs,…”
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Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells by Bianchi, Nicoletta, Finotti, Alessia, Ferracin, Manuela, Lampronti, Ilaria, Zuccato, Cristina, Breveglieri, Giulia, Brognara, Eleonora, Fabbri, Enrica, Borgatti, Monica, Negrini, Massimo, Gambari, Roberto

“…Expression and regulation of microRNAs is an emerging issue in erythroid differentiation and globin gene expression in hemoglobin disorders. In the first part…”
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trans-Resveratrol in nutraceuticals: issues in retail quality and effectiveness by Rossi, Damiano, Guerrini, Alessandra, Bruni, Renato, Brognara, Eleonora, Borgatti, Monica, Gambari, Roberto, Maietti, Silvia, Sacchetti, Gianni

“…Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their…”
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Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells by Gambari, Roberto, Borgatti, Monica, Lampronti, Ilaria, Fabbri, Enrica, Brognara, Eleonora, Bianchi, Nicoletta, Piccagli, Laura, Yuen, Marcus Chun-Wah, Kan, Chi-Wai, Hau, Desmond Kwok-Po, Fong, Wang-Fun, Wong, Wai-Yeung, Wong, Raymond Siu-Ming, Chui, Chung-Hin

“…Corilagin (beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), a gallotannin identified in several plants, including Phyllanthus urinaria, has been shown…”
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miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs by Fabbri, Enrica, Brognara, Eleonora, Borgatti, Monica, Lampronti, Ilaria, Finotti, Alessia, Bianchi, Nicoletta, Sforza, Stefano, Tedeschi, Tullia, Manicardi, Alex, Marchelli, Rosangela, Corradini, Roberto, Gambari, Roberto

“…Peptide nucleic acids (PNAs) are DNA/RNA mimics extensively used for pharmacological regulation of gene expression in a variety of cellular and molecular…”
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Peptide nucleic acids targeting miR-221 modulate p27Kip1 expression in breast cancer MDA-MB-231 cells by BROGNARA, ELEONORA, FABBRI, ENRICA, AIMI, FABIO, MANICARDI, ALEX, BIANCHI, NICOLETTA, FINOTTI, ALESSIA, BREVEGLIERI, GIULIA, BORGATTI, MONICA, CORRADINI, ROBERTO, MARCHELLI, ROSANGELA, GAMBARI, ROBERTO

“…The activity of a peptide nucleic acid (PNA) targeting cancer-associated microRNA-221 is described. PNAs against miR-221 were designed in order to bind very…”
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Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation by Avitabile, Concetta, Saviano, Michele, D'Andrea, Luca, Bianchi, Nicoletta, Fabbri, Enrica, Brognara, Eleonora, Gambari, Roberto, Romanelli, Alessandra

“…PNAs conjugated to carrier peptides have been employed for the targeting of miRNA precursor, with the aim to develop molecules able to interfere in the…”
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Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives by Romagnoli, Romeo, Baraldi, Pier Giovanni, Pavani, Maria Giovanna, Cruz-Lopez, Olga, Hamel, Ernest, Balzarini, Jan, Brognara, Eleonora, Zuccato, Cristina, Gambari, Roberto

“…Microtubules are dynamic structures that play a crucial role in cellular division and are recognized as an important target for cancer therapy. In search of…”
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Targeting miR‑155‑5p and miR‑221‑3p by peptide nucleic acids induces caspase‑3 activation and apoptosis in temozolomide‑resistant T98G glioma cells by Milani, Roberta, Brognara, Eleonora, Fabbri, Enrica, Manicardi, Alex, Corradini, Roberto, Finotti, Alessia, Gasparello, Jessica, Borgatti, Monica, Cosenza, Lucia Carmela, Lampronti, Ilaria, Dechecchi, Maria Cristina, Cabrini, Giulio, Gambari, Roberto

“…The present study investigated the effects of the combined treatment of two peptide nucleic acids (PNAs), directed against microRNAs involved in caspase‑3 mRNA…”
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Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs) by Fabbri, Enrica, Manicardi, Alex, Tedeschi, Tullia, Sforza, Stefano, Bianchi, Nicoletta, Brognara, Eleonora, Finotti, Alessia, Breveglieri, Giulia, Borgatti, Monica, Corradini, Roberto, Marchelli, Rosangela, Gambari, Roberto

“…Herein we describe the activity of a peptide nucleic acid (PNA) that targets microRNA‐210 (miR‐210), which is associated with hypoxia and is modulated during…”
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Regulation of IL-8 gene expression in gliomas by microRNA miR-93 by Fabbri, Enrica, Brognara, Eleonora, Montagner, Giulia, Ghimenton, Claudio, Eccher, Albino, Cantù, Cinzia, Khalil, Susanna, Bezzerri, Valentino, Provezza, Lisa, Bianchi, Nicoletta, Finotti, Alessia, Borgatti, Monica, Moretto, Giuseppe, Chilosi, Marco, Cabrini, Giulio, Gambari, Roberto

“…Different strategies have been proposed to target neoangiogenesis in gliomas, besides those targeting Vascular Endothelial Growth Factor (VEGF). The chemokine…”
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Corilagin Induces High Levels of Apoptosis in the Temozolomide-Resistant T98G Glioma Cell Line by Milani, Roberta, Brognara, Eleonora, Fabbri, Enrica, Finotti, Alessia, Borgatti, Monica, Lampronti, Ilaria, Marzaro, Giovanni, Chilin, Adriana, Lee, Kenneth Ka-Ho, Kok, Stanton Hon-Lung, Chui, Chung-Hin, Gambari, Roberto

“…Glioblastoma multiforme (GBM), a malignant tumor of the central nervous system, has a high mortality rate. No curative treatment is presently available, and…”
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Inhibition of Cancer Cell Proliferation and Antiradical Effects of Decoction, Hydroalcoholic Extract, and Principal Constituents of Hemidesmus indicus R. Br by Statti, Giancarlo, Marrelli, Mariangela, Conforti, Filomena, Spagnoletti, Antonella, Tacchini, Massimo, Fimognari, Carmela, Brognara, Eleonora, Gambari, Roberto, Sacchetti, Gianni, Guerrini, Alessandra

“…Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In the present work, we explored the effects of decoction,…”
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Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients by Fibach, Eitan, Prus, Eugenia, Bianchi, Nicoletta, Zuccato, Cristina, Breveglieri, Giulia, Salvatori, Francesca, Finotti, Alessia, Lipucci di Paola, Michele, Brognara, Eleonora, Lampronti, Ilaria, Borgatti, Monica, Gambari, Roberto

“…Thalassemia and sickle-cell anemia (SCA) present a major public health problem in countries where the number of carriers and affected individuals is high. As a…”
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A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction by Zuccato, Cristina, Breda, Laura, Salvatori, Francesca, Breveglieri, Giulia, Gardenghi, Sara, Bianchi, Nicoletta, Brognara, Eleonora, Lampronti, Ilaria, Borgatti, Monica, Rivella, Stefano, Gambari, Roberto

“…Gene therapy might fall short in achieving a complete reversion of the β-thalassemic phenotype due to current limitations in vector design and myeloablative…”
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