Search Results - "Broggi, Achille"

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion by Broggi, Achille, Granucci, Francesca, Zanoni, Ivan

“…Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However,…”
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Type III interferons disrupt the lung epithelial barrier upon viral recognition by Broggi, Achille, Ghosh, Sreya, Sposito, Benedetta, Spreafico, Roberto, Balzarini, Fabio, Lo Cascio, Antonino, Clementi, Nicola, De Santis, Maria, Mancini, Nicasio, Granucci, Francesca, Zanoni, Ivan

“…Viral infections of the lower respiratory tract are a leading cause of mortality. Mounting evidence indicates that most severe cases are characterized by…”
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Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs by Zanoni, Ivan, Granucci, Francesca, Broggi, Achille

“…Type III interferons (IFNs) (or IFN-λ) are the latest addition to the IFN family. Even though they share little protein homology with type I IFN, both exhibit…”
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An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells by Zanoni, Ivan, Tan, Yunhao, Di Gioia, Marco, Broggi, Achille, Ruan, Jianbin, Shi, Jianjin, Donado, Carlos A., Shao, Feng, Wu, Hao, Springstead, James R., Kagan, Jonathan C.

“…Dendritic cells (DCs) use pattern recognition receptors to detect microorganisms and activate protective immunity. These cells and receptors are thought to…”
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The interferon landscape along the respiratory tract impacts the severity of COVID-19 by Sposito, Benedetta, Broggi, Achille, Pandolfi, Laura, Crotta, Stefania, Clementi, Nicola, Ferrarese, Roberto, Sisti, Sofia, Criscuolo, Elena, Spreafico, Roberto, Long, Jaclyn M., Ambrosi, Alessandro, Liu, Enju, Frangipane, Vanessa, Saracino, Laura, Bozzini, Sara, Marongiu, Laura, Facchini, Fabio A., Bottazzi, Andrea, Fossali, Tommaso, Colombo, Riccardo, Clementi, Massimo, Tagliabue, Elena, Chou, Janet, Pontiroli, Antonio E., Meloni, Federica, Wack, Andreas, Mancini, Nicasio, Zanoni, Ivan

“…Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or…”
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Editorial: Type III interferons: Emerging roles beyond antiviral barrier defense by Boulant, Steeve, Forero, Adriana, Santer, Deanna M., Broggi, Achille

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Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence by Liu, Ning-Ning, Uppuluri, Priya, Broggi, Achille, Besold, Angelique, Ryman, Kicki, Kambara, Hiroto, Solis, Norma, Lorenz, Viola, Qi, Wanjun, Acosta-Zaldívar, Maikel, Emami, S Noushin, Bao, Bin, An, Dingding, Bonilla, Francisco A, Sola-Visner, Martha, Filler, Scott G, Luo, Hongbo R, Engström, Ylva, Ljungdahl, Per Olof, Culotta, Valeria C, Zanoni, Ivan, Lopez-Ribot, Jose L, Köhler, Julia R

“…Phosphate is an essential macronutrient required for cell growth and division. Pho84 is the major high-affinity cell-surface phosphate importer of…”
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Migratory conventional dendritic cells in the induction of peripheral T cell tolerance by Broggi, Achille, Zanoni, Ivan, Granucci, Francesca

“…Review on the contribution of gut, skin, and lung migratory DCs to peripheral tolerance, specifically Treg cell induction in homeostatic conditions…”
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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions by Broggi, Achille, Cigni, Clara, Zanoni, Ivan, Granucci, Francesca

“…The skin is a barrier organ that interacts with the external environment. Being continuously exposed to potential microbial invasion, the dermis and epidermis…”
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Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation by Poli, Valentina, Pui-Yan Ma, Victor, Di Gioia, Marco, Broggi, Achille, Benamar, Mehdi, Chen, Qian, Mazitschek, Ralph, Haggarty, Stephen J., Chatila, Talal A., Karp, Jeffrey M., Zanoni, Ivan

“…Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) driven by viruses or bacteria, as…”
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IL-15 cis Presentation Is Required for Optimal NK Cell Activation in Lipopolysaccharide-Mediated Inflammatory Conditions by Zanoni, Ivan, Spreafico, Roberto, Bodio, Caterina, Di Gioia, Marco, Cigni, Clara, Broggi, Achille, Gorletta, Tatiana, Caccia, Michele, Chirico, Giuseppe, Sironi, Laura, Collini, Maddalena, Colombo, Mario P., Garbi, Natalio, Granucci, Francesca

“…Natural killer (NK) cells have antitumor, antiviral, and antibacterial functions, and efforts are being made to manipulate them in immunotherapeutic…”
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Similarities and differences of innate immune responses elicited by smooth and rough LPS by Zanoni, Ivan, Bodio, Caterina, Broggi, Achille, Ostuni, Renato, Caccia, Michele, Collini, Maddalena, Venkatesh, Aparna, Spreafico, Roberto, Capuano, Giusy, Granucci, Francesca

“…Highlights ► rLPS induces Ca2+ mobilization in DCs in a CD14-independent manner. ► Unlike sLPS, rLPS is capable per se of activating the inflammasome in DCs. ►…”
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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions by Broggi, Achille, Cigni, Clara, Zanoni, Ivan, Granucci, Francesca

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IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function by Broggi, Achille, Tan, Yunhao, Granucci, Francesca, Zanoni, Ivan

“…The effect of the cytokine IFN-λ in non-epithelial cells remains unclear. Zanoni and colleagues show that IFN-λ specifically activates a signaling pathway that…”
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Microbe- and danger-induced inflammation by Broggi, Achille, Granucci, Francesca

“…•Microbial stimuli induce the activation of both innate and adaptive immunity.•Danger signals induce the activation of inflammation and wound healing.•Microbe-…”
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Editorial: Type III interferons: Emerging roles beyond antiviral barrier defense by Boulant, Steeve, Forero, Adriana, Santer, Deanna M, Broggi, Achille

“…Type III interferons or IFN-λs, are composed of 4 members: IFN-λ1, IFN-λ2, IFN-λ3, and IFN-λ4. IFN-λs are master protectors against mucosal viral infections…”
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Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections by Harb, Hani, Benamar, Mehdi, Lai, Peggy S., Contini, Paola, Griffith, Jason W., Crestani, Elena, Schmitz-Abe, Klaus, Chen, Qian, Fong, Jason, Marri, Luca, Filaci, Gilberto, Del Zotto, Genny, Pishesha, Novalia, Kolifrath, Stephen, Broggi, Achille, Ghosh, Sreya, Gelmez, Metin Yusuf, Oktelik, Fatma Betul, Cetin, Esin Aktas, Kiykim, Ayca, Kose, Murat, Wang, Ziwei, Cui, Ye, Yu, Xu G., Li, Jonathan Z., Berra, Lorenzo, Stephen-Victor, Emmanuel, Charbonnier, Louis-Marie, Zanoni, Ivan, Ploegh, Hidde, Deniz, Gunnur, De Palma, Raffaele, Chatila, Talal A.

“…A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective multi-country cohort of COVID-19 patients, we found that…”
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IFN-[lambda] suppresses intestinal inflammation by non-translational regulation of neutrophil function by Broggi, Achille, Tan, Yunhao, Granucci, Francesca, Zanoni, Ivan

“…Interferon-[lambda] (IFN-[lambda]) is a central regulator of mucosal immunity; however, its signaling specificity relative to that of type I interferons is…”
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Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis by Millet, Virginie, Gensollen, Thomas, Maltese, Michael, Serrero, Melanie, Lesavre, Nathalie, Bourges, Christophe, Pitaval, Christophe, Cadra, Sophie, Chasson, Lionel, Vu Man, Thien Phong, Masse, Marion, Martinez-Garcia, Juan Jose, Tranchida, Fabrice, Shintu, Laetitia, Mostert, Konrad, Strauss, Erick, Lepage, Patricia, Chamaillard, Mathias, Broggi, Achille, Peyrin-Biroulet, Laurent, Grimaud, Jean-Charles, Naquet, Philippe, Galland, Franck

“…In the management of patients with IBD, there is a need to identify prognostic markers and druggable biological pathways to improve mucosal repair and probe…”
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Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells by Vitali, Caterina, Mingozzi, Francesca, Broggi, Achille, Barresi, Simona, Zolezzi, Francesca, Bayry, Jagadeesh, Raimondi, Giorgio, Zanoni, Ivan, Granucci, Francesca

“…There is evidence that dendritic cells (DCs) induce peripheral tolerance. Nevertheless, it is not known whether immature DCs in general are able to tolerize…”
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