Search Results - "Broers, J L"

Nuclear Lamins: Laminopathies and Their Role in Premature Ageing by Broers, J. L. V, Ramaekers, F. C. S, Bonne, G, Yaou, R. Ben, Hutchison, C. J

“…Department of Molecular Cell Biology, University of Maastricht, Research Institutes CARIM, GROW, and EURON, Maastricht; Department of Biomechanics and Tissue…”
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The nuclear envelope, a key structure in cellular integrity and gene expression by Verstraeten, V L R M, Broers, J L V, Ramaekers, F C S, van Steensel, M A M

“…The envelope that encapsulates the cell nucleus has recently gained considerable interest, as several clinical syndromes are linked to mutations in its…”
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Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts by van Loosdregt, I. A. E. W, Kamps, M. A. F, Oomens, C. W. J, Loerakker, S, Broers, J. L. V, Bouten, C. V. C

“…In order to maintain tissue homeostasis and functionality, adherent cells need to sense and respond to environmental mechanical stimuli. An important ability…”
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Cytoplasmic localization of PML particles in laminopathies by Houben, F., De Vos, W. H., Krapels, I. P. C., Coorens, M., Kierkels, G. J. J., Kamps, M. A. F., Verstraeten, V. L. R. M., Marcelis, C. L. M., van den Wijngaard, A., Ramaekers, F. C. S., Broers, J. L. V.

“…There is growing evidence that laminopathies, diseases associated with mutations in the LMNA gene, are caused by a combination of mechanical and gene…”
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A newly identified splice site mutation in ZMPSTE24 causes restrictive dermopathy in the Middle East by Sander, C.S., Salman, N., Van Geel, M., Broers, J.L.V., Al‐Rahmani, A., Chedid, F., Hausser, I., Oji, V., Al Nuaimi, K., Berger, T.G., Verstraeten, V.L.R.M.

“…Summary Restrictive dermopathy (RD) is a severe neonatal inherited skin syndrome of which children die shortly after birth. Clinical features include…”
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Role of nuclear lamina-cytoskeleton interactions in the maintenance of cellular strength by Houben, F., Ramaekers, F.C.S., Snoeckx, L.H.E.H., Broers, J.L.V.

“…The response of individual cells to cellular stress is vital for cellular functioning. A large network of physically interconnected cellular components,…”
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Nuclear A-type lamins are differentially expressed in human lung cancer subtypes by Broers, JL, Raymond, Y, Rot, MK, Kuijpers, H, Wagenaar, SS, Ramaekers, FC

“…Nuclear A-type and B-type lamin expression was investigated in the major human lung cancer subtypes: small cell lung cancer (SCLC), squamous cell carcinomas,…”
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Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells by Houben, F., Willems, C.H.M.P., Declercq, I.L.J., Hochstenbach, K., Kamps, M.A., Snoeckx, L.H.E.H., Ramaekers, F.C.S., Broers, J.L.V.

“…The nuclear lamina and the cytoskeleton form an integrated structure that warrants proper mechanical functioning of cells. We have studied the correlation…”
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Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product by ROEBROEK, A. J. M, VAN DE VELDE, H. J. K, VAN BOKHOVEN, A, BROERS, J. L. V, RAMAEKERS, F. C. S, VAN DE VEN, W. J. M

“…Monoclonal antibodies RNL-2 and RNL-3 were previously shown to react with four 35-45-kDa proteins, expressed only in small cell lung carcinoma NCI-H82 cells,…”
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Expression of c-myc in progenitor cells of the bronchopulmonary epithelium and in a large number of non-small cell lung cancers by Broers, J L, Viallet, J, Jensen, S M, Pass, H, Travis, W D, Minna, J D, Linnoila, R I

“…We performed in situ hybridization for c-myc, N-myc, and L-myc mRNA expression using 35S-labeled cRNA probes on frozen sections of 19 pairs of non-small cell…”
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Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma by Tilli, C.M.L.J., Ramaekers, F.C.S., Broers, J.L.V., Hutchison, C.J., Neumann, H.A.M.

“…Summary Background  Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its…”
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Intermediate filament proteins in classic and variant types of small cell lung carcinoma cell lines: a biochemical and immunochemical analysis using a panel of monoclonal and polyclonal antibodies by BROERS, J. L. V, CARNEY, D. N, KLEIN ROT, M, SCHAART, G, LANE, E. B, VOOIJS, G. P, RAMAEKERS, F. C. S

“…The intermediate filament protein (IFP) characteristics of a panel of lung cancer cell lines including adenocarcinoma (two cell lines) and small cell lung…”
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Dynamics of the nuclear lamina as monitored by GFP-tagged A-type lamins by Broers, J L, Machiels, B M, van Eys, G J, Kuijpers, H J, Manders, E M, van Driel, R, Ramaekers, F C

“…The behavior of chimeric proteins consisting of A-type lamins and green fluorescent protein (GFP) was studied to investigate the localization and dynamics of…”
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A- and B-type lamins are differentially expressed in normal human tissues by Broers, J L, Machiels, B M, Kuijpers, H J, Smedts, F, van den Kieboom, R, Raymond, Y, Ramaekers, F C

“…A selection of normal human tissues was investigated for the presence of lamins B1, B2, and A-type lamins, using a panel of antibodies specific for the…”
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Differential Expression of Intermediate Filament Proteins Distinguishes Classic from Variant Small-Cell Lung Cancer Cell Lines by Broers, J. L. V., Carney, D. N., De Ley, L., Vooijs, G. P., Ramaekers, F. C. S.

“…The expression of intermediate filament proteins in classic and variant-type small-cell lung carcinoma (SCLC) cell lines was studied using immunocytochemical…”
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Cytokeratins expressed in experimental rat bronchial carcinomas by Kal, H B, van Berkel, A H, Broers, J L, Klein, J C, Mijnheere, E P, Roholl, P J, Zurcher, C, Ramaekers, F C

“…Cytokeratin expression in rat lung tumors was studied using polypeptide-specific monoclonal antibodies (MAbs) to human cytokeratins 4, 5, 7, 8, 10, 13, 14, 18…”
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Biodistribution of a monoclonal antibody (RNL-1) against the neural cell adhesion molecule (NCAM) in athymic mice bearing human small-cell lung-cancer xenografts by Boerman, O C, Mijnheere, E P, Broers, J L, Vooijs, G P, Ramaekers, F C

“…The purpose of this investigation was to determine the targeting potential of the murine monoclonal antibody (MAb) RNL-1 for human small-cell lung cancer…”
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Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines by BROERS, J. L. V, KLEIN ROT, M, OOSTENDORP, T, BEPLER, G, DE LEIJ, L, CARNEY, D. N, VOOIJS, G. P, RAMAEKERS, F. C. S

“…The usefulness of cell lines in the study and prediction of the clinical behaviour of lung cancer is still a matter of debate. However, lung tumour cell…”
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Cytokeratins in different types of human lung cancer as monitored by chain-specific monoclonal antibodies by BROERS, J. L. V, RAMAEKERS, F. C. S, ROT, M. K, OOSTENDORP, T, HUYSMANS, A, VAN MUIJEN, G. N. P, WAGENAAR, S. S, VOOIJS, G. P

“…The expression of cytokeratins (CKs) in human lung cancer was studied using chain-specific monoclonal antibodies to CKs 4, 7, 8, 10, 13, 18, and 19. When…”
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Expression of surfactant associated protein-A and Clara cell 10 kilodalton mRNA in neoplastic and non-neoplastic human lung tissue as detected by in situ hybridization by Broers, J L, Jensen, S M, Travis, W D, Pass, H, Whitsett, J A, Singh, G, Katyal, S L, Gazdar, A F, Minna, J D, Linnoila, R I

“…Two markers for the progenitor cells of peripheral airways and their tumors are the 10 kilodalton (kd) Clara cell protein and the major surfactant associated…”
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