Search Results - "Broering, R"

Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen by Jiang, M., Broering, R., Trippler, M., Poggenpohl, L., Fiedler, M., Gerken, G., Lu, M., Schlaak, J. F.

“…Summary It has been recently shown that Toll‐like receptor (TLR) signalling in murine nonparenchymal liver cells (NPCs) is suppressed in the presence of…”
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MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver by Jiang, M., Broering, R., Trippler, M., Wu, J., Zhang, E., Zhang, X., Gerken, G., Lu, M., Schlaak, J. F.

“…Summary The hepatitis C virus (HCV) establishes persistent infections despite strong activation of the innate immune system through TLR3 and other sensors…”
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The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response by Broering, Ruth, Zhang, Xiaozhen, Kottilil, Shyam, Trippler, Martin, Jiang, Min, Lu, Mengji, Gerken, Guido, Schlaak, Joerg F

“…Non-response to combination therapy by patients with hepatitis C virus (HCV) has previously been associated with a strong hepatic upregulation of interferon…”
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Hepatic expression of oncogenes Bmi1 and Dkk1 can be induced by treatment with hepatitis B virus particles or Lipopolysaccharide in vitro and is up-regulated in liver biopsies of patients with chronic HBV infection by Zhang, R, Real, C.I, Liu, C, Hideo, B.A, Gerken, G, Lu, M, Broering, R

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Nucleic Acid-Based Polymers Effective against Hepatitis B Virus Infection in Patients Do Not Harbour Immune Stimulatory Properties in Primary Isolated Blood or Liver Cells by Real, C, Werner, M, Paul, A, Gerken, G, Schlaak, J, Vaillant, A, Broering, R

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Long-term stimulation of Toll-like receptor 3 in primary human hepatocytes leads to sensitization for antiviral responses induced by poly I:C treatment by Broering, R., Lutterbeck, M., Trippler, M., Kleinehr, K., Poggenpohl, L., Paul, A., Gerken, G., Schlaak, J. F.

“…Summary Chronic hepatitis C infection is associated with increased expression of interferon‐sensitive genes (ISGs) in the liver, which is, paradoxically,…”
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P0705 : Antiviral activity of human non-parenchymal liver cells is restricted to toll-like receptor 3 and involves type I interferons by Lutterbeck, M, Driftmann, S, Kleinehr, K, Paul, A, Gerken, G, Schlaak, J.F, Broering, R

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Hepatitis B Virus Activates Toll-Like Receptor 2 Signaling upon Infection of Primary Human Hepatocytes by Broering, R, Zhang, Z, Trippler, M, Real, C, Werner, M, Gerken, G, Schlaak, J, Lu, M

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P218 TOLL-LIKE RECEPTOR 3 STIMULATION OF HUMAN NON-PARENCHYMAL LIVER CELLS TRIGGERS AN ANTIVIRAL STATE AGAINST HCV WHICH IS NOT EXCLUSIVELY MEDIATED BY TYPE-I OR TYPE-III IFNS by Lutterbeck, M, Broering, R, Kleinehr, K, Paul, A, Gerken, G, Schlaak, J.F

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Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of ISG15 ubiquitin-like modifier, a proviral host gene in hepatitis C virus infection by Broering, R., Trippler, M., Werner, M., Real, C. I., Megger, D. A., Bracht, T., Schweinsberg, V., Sitek, B., Eisenacher, M., Meyer, H. E., Baba, H. A., Weber, F., Hoffmann, A.-C., Gerken, G., Schlaak, J. F.

“…Summary The interferon‐stimulated gene 15 (ISG15) plays an important role in the pathogenesis of hepatitis C virus (HCV) infection. ISG15‐regulated proteins…”
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347 REPETITIVE ACTIVATION OF TOLL-LIKE RECEPTOR 3 IN PRIMARY HUMAN HEPATOCYTES LEADS TO HYPER-RESPONSIVENESS TO POLY I:C IN VITRO by Broering, R, Lutterbeck, M, Trippler, M, Paul, A, Kleinehr, K, Gerken, G, Schlaak, J.F

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814 PRIMARY HUMAN HEPATOCYTES INHIBIT EXPANSION OF VIRUS-SPECIFIC CD8+ T CELLS IN VITRO by Ziegler, S, Broering, R, Nahmias, Y, Schlaak, J.F, Timm, J

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P150 INTERFERON-STIMULATED GENE 15, A PROVIRAL FACTOR FOR HEPATITIS C VIRUS, AND PROTEASOME SUBUNIT ALPHA TYPE-6 ARE INDUCED BY POLY(I:C) AND RECIPROCALLY AFFECT EACH OTHER by Broering, R, Trippler, M, Lutterbeck, M, Real, C.I, Kleinehr, K, Poggenpohl, L, Gerken, G, Schlaak, J.F

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P0696 : Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection by Broering, R, Trippler, M, Lutterbeck, M, Real, C.I, Megger, D.A, Bracht, T, Schweinsberg, V, Sitek, B, Eisenacher, M, Meyer, H.E, Baba, H.A, Weber, F, Hoffmann, A.-C, Gerken, G, Schlaak, J.F

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LP45 : The hepatitis B virus (HBV) surface antigen impedes hepadnaviral replication-dependent interferon responses in a HBV transgenic mouse model by Real, C.I, Lu, M, Hossbach, M, Deckert, J, Jahn-Hofmann, K, Ickenstein, L.M, John, M.J, Trippler, M, Gibbert, K, Dittmer, U, Vornlocher, H.-P, Schirmbeck, R, Gerken, G, Schlaak, J.F, Broering, R

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Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state by Broering, Ruth, Montag, Mario, Jiang, Min, Lu, Mengji, Sowa, Jan-Peter, Kleinehr, Kathrin, Gerken, Guido, Schlaak, Joerg F

“…Only little is known about the mechanisms of action of corticosteroids in the treatment of inflammatory liver diseases. As there is increasing evidence that…”
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397 THE PRO-INFLAMMATORY RESPONSE INDUCED BY TOLL-LIKE RECEPTOR ACTIVATION IN VIVO IS NOT IMPAIRED IN THE LIVER OF HBV-TRANSGENIC MICE LACKING HBsAg by Real, C.I, Broering, R, Kleinehr, K, Driftmann, S, Schirmbeck, R, Lu, M, Gerken, G, Schlaak, J.F

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P151 HEPADNAVIRAL REPLICATION IN HBV-TRANSGENIC MICE LACKING THE SURFACE ANTIGEN IS ACCOMPANIED BY TOLL-LIKE RECEPTOR 3 MEDIATED INTERFERON RESPONSES by Real, C.I, Broering, R, Jahn-Hofmann, K, Ickenstein, L, John, M, Kleinehr, K, Driftmann, S, Lutterbeck, M, Kemper, T, Vornlocher, H.-P, Schirmbeck, R, Lu, M, Gerken, G, Schlaak, J.F

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768 THE TOLL-LIKE RECEPTOR MEDIATED PRODUCTION OF INTERFERONS AND IMMUNOMODULATORY CYTOKINES IS NOT IMPAIRED IN PRIMARY LIVER CELLS FROM HCV-POSITIVE PATIENTS by Broering, R, Kleinehr, K, Paul, A, Gerken, G, Schlaak, J.F

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306 ISG15 AND MICRORNA-122 REGULATE HEPATITIS C VIRUS REPLICATION INDEPENDENTLY by Pankraz, O, Broering, R, Trippler, M, Gerken, G, Schlaak, J.F

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