Search Results - "Broenstrup, Mark"

Armeniaspiroles, a new class of antibacterials: antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A by Couturier, Cédric, Bauer, Armin, Rey, Astrid, Schroif-Dufour, Cosima, Broenstrup, Mark

“…Armeniaspiroles, a novel class of natural products isolated from Streptomyces armeniacus, are characterized by a novel spiro[4.4]non-8-ene scaffold. Various…”
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Elucidating the mechanism behind and investigating the efficacy of Traditional Chinese Medicine and Traditional Tibetan Medicine in combination with standard therapeutics in hepatocellular carcinoma and cholangiocarcinoma in vitro by Suo, Huizhen, Hochnadel, Inga, Petriv, Nataliia, Franke, Raimo, Schmidt, Jennifer, Limanska, Nataliia, Tugai, Alisa, Jedicke, Nils, Broenstrup, Mark, Manns, Michael P., Yevsa, Tetyana

“…In this study, we investigated compounds of plant and mushroom origin belonging to Traditional Chinese Medicine (TCM) and to Traditional Tibetan Medicine…”
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Influence of fenofibrate treatment on triacylglycerides, diacylglycerides and fatty acids in fructose fed rats by Kopf, Thomas, Schaefer, Hans-Ludwig, Troetzmueller, Martin, Koefeler, Harald, Broenstrup, Mark, Konovalova, Tatiana, Schmitz, Gerd

“…Fenofibrate (FF) lowers plasma triglycerides via PPARα activation. Here, we analyzed lipidomic changes upon FF treatment of fructose fed rats. Three groups…”
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Species-Specific Conservation of Linear Antigenic Sites on Vaccinia Virus A27 Protein Homologs of Orthopoxviruses by Ahsendorf, Henrike P, Gan, Li L, Eltom, Kamal H, Abd El Wahed, Ahmed, Hotop, Sven-Kevin, Roper, Rachel L, Beutling, Ulrike, Broenstrup, Mark, Stahl-Hennig, Christiane, Hoelzle, Ludwig E, Czerny, Claus-Peter

“…The vaccinia virus (VACV) A27 protein and its homologs, which are found in a large number of members of the genus (OPXV), are targets of viral neutralization…”
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Transcriptional and Proteomic Profiles of Group B Streptococcus Type V Reveal Potential Adherence Proteins Associated with High-Level Invasion by JOHRI, Atul K, MARGARIT, Immaculada, BROENSTRUP, Mark, BRETTONI, Cecilia, LEI HUA, GYGI, Steven P, TELFORD, John L, GRANDI, Guido, LAWRENCE, C. Paoletti

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram‐Positive Directed Antibacterial Effects by Schmidt, Claudia, Karge, Bianka, Misgeld, Rainer, Prokop, Aram, Franke, Raimo, Brönstrup, Mark, Ott, Ingo

“…Gold complexes with N‐heterocyclic carbene (NHC) ligands represent a promising class of metallodrugs for the treatment of cancer or infectious diseases. In…”
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CluMSID: an R package for similarity-based clustering of tandem mass spectra to aid feature annotation in metabolomics by Depke, Tobias, Franke, Raimo, Brönstrup, Mark

“…Compound identification is one of the most eminent challenges in the untargeted analysis of complex mixtures of small molecules by mass spectrometry…”
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Gold(I) and Gold(III) N‐Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase by Büssing, Rolf, Karge, Bianka, Lippmann, Petra, Jones, Peter G., Brönstrup, Mark, Ott, Ingo

“…A series of (NHC)Au(I)Cl monocarbene complexes and their gold(III) analogues (NHC)Au(III)Cl3 were prepared and investigated as antibacterial agents and…”
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Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids by Testolin, Giambattista, Richter, Jana, Ritter, Antje, Prochnow, Hans, Köhnke, Jesko, Brönstrup, Mark

“…The rise of antibiotic resistance causes a serious health care problem, and its counterfeit demands novel, innovative concepts. The combination of…”
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Muscle-Type Specific Intramyocellular and Hepatic Lipid Metabolism During Starvation in Wistar Rats by NEUMANN-HAEFELIN, Claudia, BEHA, Anja, SCHAEFER, Hans-Ludwig, SCHMOLL, Dieter, KRAMER, Werner, JURETSCHKE, Hans-Paul, HERLING, Andreas W, KUHLMANN, Johanna, BELZ, Ulrich, GERL, Martin, QUINT, Manfred, BIEMER-DAUB, Gabriele, BROENSTRUP, Mark, STEIN, Marion, KLEINSCHMIDT, Elke

“…Muscle-Type Specific Intramyocellular and Hepatic Lipid Metabolism During Starvation in Wistar Rats Claudia Neumann-Haefelin , Anja Beha , Johanna Kuhlmann ,…”
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Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation by Raud, Brenda, Roy, Dominic G., Divakaruni, Ajit S., Tarasenko, Tatyana N., Franke, Raimo, Ma, Eric H., Samborska, Bozena, Hsieh, Wei Yuan, Wong, Alison H., Stüve, Philipp, Arnold-Schrauf, Catharina, Guderian, Melanie, Lochner, Matthias, Rampertaap, Shakuntala, Romito, Kimberly, Monsale, Joseph, Brönstrup, Mark, Bensinger, Steven J., Murphy, Anne N., McGuire, Peter J., Jones, Russell G., Sparwasser, Tim, Berod, Luciana

“…T cell subsets including effector (Teff), regulatory (Treg), and memory (Tmem) cells are characterized by distinct metabolic profiles that influence their…”
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Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram‐Negative Pathogens by Hüttel, Stephan, Testolin, Giambattista, Herrmann, Jennifer, Planke, Therese, Gille, Franziska, Moreno, Maria, Stadler, Marc, Brönstrup, Mark, Kirschning, Andreas, Müller, Rolf

“…Antibiotic discovery and development is challenging as chemical scaffolds of synthetic origin often lack the required pharmaceutical properties, and the…”
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Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity by Lukat, Peer, Katsuyama, Yohei, Wenzel, Silke, Binz, Tina, König, Claudia, Blankenfeldt, Wulf, Brönstrup, Mark, Müller, Rolf

“…Griselimycins (GMs) are depsidecapeptides with superb anti-tuberculosis activity. They contain up to three (2 ,4 )-4-methyl-prolines (4-MePro), of which one…”
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Metabolome and transcriptome-wide effects of the carbon storage regulator A in enteropathogenic Escherichia coli by Berndt, Volker, Beckstette, Michael, Volk, Marcel, Dersch, Petra, Brönstrup, Mark

“…The carbon storage regulator A (CsrA) is a conserved global regulatory system known to control central carbon pathways, biofilm formation, motility, and…”
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Subcellular Quantification of Uptake in Gram-Negative Bacteria by Prochnow, Hans, Fetz, Verena, Hotop, Sven-Kevin, García-Rivera, Mariel A, Heumann, Axel, Brönstrup, Mark

“…Infections by Gram-negative pathogens represent a major health care issue of growing concern due to a striking lack of novel antibacterial agents over the…”
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Trojan Horse Siderophore Conjugates Induce Pseudomonas aeruginosa Suicide and Qualify the TonB Protein as a Novel Antibiotic Target by Peukert, Carsten, Gasser, Véronique, Orth, Till, Fritsch, Sarah, Normant, Vincent, Cunrath, Olivier, Schalk, Isabelle J., Brönstrup, Mark

“…Rising infection rates with multidrug-resistant pathogens calls for antibiotics with novel modes of action. Herein, we identify the inner membrane protein…”
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Biscarbene gold(i) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability by Schmidt, Claudia, Karge, Bianka, Misgeld, Rainer, Prokop, Aram, Brönstrup, Mark, Ott, Ingo

“…A series of gold(i) complexes with two N-heterocyclic carbene ligands (biscarbene gold complexes) were prepared and evaluated for their effects against cancer…”
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Clustering of MS2 spectra using unsupervised methods to aid the identification of secondary metabolites from Pseudomonas aeruginosa by Depke, Tobias, Franke, Raimo, Brönstrup, Mark

“…•We developed a tool to cluster MS2 spectra and neutral loss patterns by similarity.•CluMSID enabled putative annotation of more than 30 novel alkyl…”
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Multivalent Siderophore–DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial Infections by Ferreira, Kevin, Hu, Hai‐Yu, Fetz, Verena, Prochnow, Hans, Rais, Bushra, Müller, Peter P., Brönstrup, Mark

“…There is a strong need to better diagnose infections at deep body sites through noninvasive molecular imaging methods. Herein, we describe the synthesis and…”
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A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs by Schmidt, Claudia, Albrecht, Lucia, Balasupramaniam, Shantheya, Misgeld, Rainer, Karge, Bianka, Brönstrup, Mark, Prokop, Aram, Baumann, Knut, Reichl, Stephan, Ott, Ingo

“…Gold complexes with N-heterocyclic carbene (NHC) ligands have been attracting major attention in medicinal inorganic chemistry based on their favorable…”
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