Search Results - "Broemer, Meike"

M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila by Aalto, Anna L., Mohan, Aravind K., Schwintzer, Lukas, Kupka, Sebastian, Kietz, Christa, Walczak, Henning, Broemer, Meike, Meinander, Annika

“…Post-translational modifications such as ubiquitination play a key role in regulation of inflammatory nuclear factor-κB (NF-κB) signalling. The Drosophila IκB…”
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Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family by Louis, Marcell, Hofmann, Kay, Broemer, Meike

“…Understanding function and specificity of de-ubiquitylating enzymes (DUBs) is a major goal of current research, since DUBs are key regulators of ubiquitylation…”
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Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation by BROEMER, Meike, KRAPPMANN, Daniel, SCHEIDEREIT, Claus

“…The molecular chaperone Hsp90 affects the function and fate of a number of signaling molecules. We have investigated the Hsp90 requirement for constitutive and…”
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Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth by Wakabayashi, Satoru, Sawamura, Naoya, Voelzmann, André, Broemer, Meike, Asahi, Toru, Hoch, Michael

“…Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that is highly conserved in animals and plants. CRBN proteins have been implicated…”
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Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis by Meier, Pascal, Morris, Otto, Broemer, Meike

“…Cell death and inflammation are ancient processes of fundamental biological importance in both normal physiology and human disease pathologies. The recent…”
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Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes by Ertürk-Hasdemir, Deniz, Broemer, Meike, Leulier, François, Lane, William S, Paquette, Nicholas, Hwang, Daye, Kim, Chan-Hee, Stöven, Svenja, Meier, Pascal, Silverman, Neal

“…The Drosophila NF-κB transcription factor Relish is an essential regulator of antimicrobial peptide gene induction after Gram-negative bacterial infection…”
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Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases by Broemer, Meike, Tenev, Tencho, Rigbolt, Kristoffer T.G., Hempel, Sophie, Blagoev, Blagoy, Silke, John, Ditzel, Mark, Meier, Pascal

“…The intimate relationship between mediators of the ubiquitin (Ub)-signaling system and human diseases has sparked profound interest in how Ub influences cell…”
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CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration by Lopez, Juanita, John, Sidonie Wicky, Tenev, Tencho, Rautureau, Gilles J.P., Hinds, Mark G., Francalanci, Floriana, Wilson, Rebecca, Broemer, Meike, Santoro, Massimo M., Day, Catherine L., Meier, Pascal

“…E3 ligases mediate the covalent attachment of ubiquitin to target proteins thereby enabling ubiquitin-dependent signaling. Unraveling how E3 ligases are…”
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Inactivation of Effector Caspases through Nondegradative Polyubiquitylation by Ditzel, Mark, Broemer, Meike, Tenev, Tencho, Bolduc, Clare, Lee, Tom V., Rigbolt, Kristoffer T.G., Elliott, Richard, Zvelebil, Marketa, Blagoev, Blagoy, Bergmann, Andreas, Meier, Pascal

“…Ubiquitin-mediated inactivation of caspases has long been postulated to contribute to the regulation of apoptosis. However, detailed mechanisms and functional…”
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TRIAD3/RNF216 E3 ligase specifically synthesises K63-linked ubiquitin chains and is inactivated by mutations associated with Gordon Holmes syndrome by Schwintzer, Lukas, Aguado Roca, Eva, Broemer, Meike

“…TRIAD3/RNF216 is a ubiquitin ligase of the RING-in-between-RING family. Recent publications identified TRIAD3 mutations in patients with neurological diseases,…”
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Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation by Lee, Tom V, Fan, Yun, Wang, Shiuan, Srivastava, Mayank, Broemer, Meike, Meier, Pascal, Bergmann, Andreas

“…Ubiquitylation targets proteins for proteasome-mediated degradation and plays important roles in many biological processes including apoptosis. However,…”
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The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila by Koerver, Lisa, Melzer, Juliane, Roca, Eva Aguado, Teichert, Dominic, Glatter, Timo, Arama, Eli, Broemer, Meike

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The MAPK Kinase Kinase TAK1 Plays a Central Role in Coupling the Interleukin-1 Receptor to Both Transcriptional and RNA-targeted Mechanisms of Gene Regulation by Holtmann, Helmut, Enninga, Jost, Kälble, Solveig, Thiefes, Axel, Dörrie, Anneke, Broemer, Meike, Winzen, Reinhard, Wilhelm, Arno, Ninomiya-Tsuji, Jun, Matsumoto, Kunihiro, Resch, Klaus, Kracht, Michael

“…Mechanisms of fulminant gene induction during an inflammatory response were investigated using expression of the chemoattractant cytokine interleukin-8 (IL-8)…”
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The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs by Tenev, Tencho, Bianchi, Katiuscia, Darding, Maurice, Broemer, Meike, Langlais, Claudia, Wallberg, Fredrik, Zachariou, Anna, Lopez, Juanita, MacFarlane, Marion, Cain, Kelvin, Meier, Pascal

“…A better understanding of the mechanisms through which anticancer drugs exert their effects is essential to improve combination therapies. While studying how…”
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Ubiquitin-mediated regulation of apoptosis by Broemer, Meike, Meier, Pascal

“…Ubiquitin is a protein modifier that is conjugated to target proteins either as a single moiety or as polyubiquitin chains. Over the past several years, an…”
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Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease by Schilling, Judith, Broemer, Meike, Atanassov, Ilian, Duernberger, Yvonne, Vorberg, Ina, Dieterich, Christoph, Dagane, Alina, Dittmar, Gunnar, Wanker, Erich, van Roon-Mom, Willeke, Winter, Jennifer, Krauß, Sybille

“…Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin (HTT) gene, translating into an elongated polyglutamine stretch. In addition to…”
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Nerve-racking - apoptotic and non-apoptotic roles of caspases in the nervous system of Drosophila by Melzer, Juliane, Broemer, Meike

“…Studies using Drosophila as a model system have contributed enormously to our knowledge of caspase function and regulation. Caspases are best known as central…”
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M1‐linked ubiquitination facilitates NF‐κB activation and survival during sterile inflammation by Aalto, Anna, Martínez‐Chacón, Gabriela, Kietz, Christa, Tsyganova, Nadezhda, Kreutzer, Joose, Kallio, Pasi, Broemer, Meike, Meinander, Annika

“…Methionine 1 (M1)‐linked ubiquitination plays a key role in the regulation of inflammatory nuclear factor‐κB (NF‐κB) signalling and is important for clearance…”
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New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules by Das, Richa, Schwintzer, Lukas, Vinopal, Stanislav, Aguado Roca, Eva, Sylvester, Marc, Oprisoreanu, Ana-Maria, Schoch, Susanne, Bradke, Frank, Broemer, Meike

“…Mechanisms that regulate the formation of membrane-less cellular organelles, such as neuronal RNA granules and stress granules, have gained increasing…”
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The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila by Koerver, Lisa, Melzer, Juliane, Roca, Eva Aguado, Teichert, Dominic, Glatter, Timo, Arama, Eli, Broemer, Meike

“…De-ubiquitylating enzymes (DUBs) reverse protein ubiquitylation and thereby control essential cellular functions. Screening for a DUB that counteracts caspase…”
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