Search Results - "Broekman, Marike L. D"

Glioblastoma hijacks microglial gene expression to support tumor growth by Maas, Sybren L N, Abels, Erik R, Van De Haar, Lieke L, Zhang, Xuan, Morsett, Liza, Sil, Srinjoy, Guedes, Joana, Sen, Pritha, Prabhakar, Shilpa, Hickman, Suzanne E, Lai, Charles P, Ting, David T, Breakefield, Xandra O, Broekman, Marike L D, El Khoury, Joseph

“…Glioblastomas are the most common and lethal primary brain tumors. Microglia, the resident immune cells of the brain, survey their environment and respond to…”
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Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results by Senders, Joeky T., Muskens, Ivo S., Schnoor, Rosalie, Karhade, Aditya V., Cote, David J., Smith, Timothy R., Broekman, Marike L. D.

“…Background Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection…”
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Developer perspectives on the ethics of AI-driven neural implants: a qualitative study by van Stuijvenberg, Odile C., Broekman, Marike L. D., Wolff, Samantha E. C., Bredenoord, Annelien L., Jongsma, Karin R.

“…Convergence of neural implants with artificial intelligence (AI) presents opportunities for the development of novel neural implants and improvement of…”
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Trends in cerebrospinal fluid leak rates following the extended endoscopic endonasal approach for anterior skull base meningioma: a meta-analysis over the last 20 years by Zamanipoor Najafabadi, Amir H., Khan, Danyal Z., Muskens, Ivo S, Broekman, Marike L. D., Dorward, Neil L., van Furth, Wouter R., Marcus, Hani J.

“…Objective The extended endoscopic approach provides unimpaired visualization and direct access to ventral skull base pathology, but is associated with…”
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AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival by Baek, Rena C, Broekman, Marike L D, Leroy, Stanley G, Tierney, Laryssa A, Sandberg, Michael A, d'Azzo, Alessandra, Seyfried, Thomas N, Sena-Esteves, Miguel

“…GM1-gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by a genetic deficiency of acid β-galactosidase (βgal), which results in the…”
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Systemic therapy following craniotomy in patients with a solitary breast cancer brain metastasis by Hulsbergen, Alexander F. C., Cho, Logan D., Mammi, Marco, Lamba, Nayan, Smith, Timothy R., Brastianos, Priscilla K., Broekman, Marike L. D., Lin, Nancy U.

“…Purpose To describe practice patterns and patient outcomes with respect to the use of postoperative systemic therapy (ST) after resection of a solitary breast…”
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Advances in local therapy for glioblastoma — taking the fight to the tumour by van Solinge, Thomas S., Nieland, Lisa, Chiocca, E. Antonio, Broekman, Marike L. D.

“…Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains one of the most treatment-resistant CNS malignancies, and the tumour…”
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Potential impact of invasive surgical procedures on primary tumor growth and metastasis by Alieva, Maria, van Rheenen, Jacco, Broekman, Marike L. D.

“…Surgical procedures such as tumor resection and biopsy are still the gold standard for diagnosis and (determination of) treatment of solid tumors, and are…”
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Overcoming Barriers in Glioblastoma-Advances in Drug Delivery Strategies by Ter Linden, Esther, Abels, Erik R, van Solinge, Thomas S, Neefjes, Jacques, Broekman, Marike L D

“…The world of cancer treatment is evolving rapidly and has improved the prospects of many cancer patients. Yet, there are still many cancers where treatment…”
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Quantification of nanosized extracellular membrane vesicles with scanning ion occlusion sensing by de Vrij, Jeroen, Maas, Sybren L N, van Nispen, Malisa, Sena-Esteves, Miguel, Limpens, Ronald W A, Koster, Abraham J, Leenstra, Sieger, Lamfers, Martine L, Broekman, Marike L D

“…Cells secrete different types of membrane vesicles (MVs), which may act as important entities in normal human physiology and in various pathological processes…”
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Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics—a prospective multicenter cohort study by van Opijnen, Mark P, Broekman, Marike L. D, de Vos, Filip Y. F, Cuppen, Edwin, van der Hoeven, Jacobus J. M, van Linde, Myra E, Compter, Annette, Beerepoot, Laurens V, van den Bent, Martin J, Vos, Maaike J, Fiebrich, Helle-Brit, Koekkoek, Johan A. F, Hoeben, Ann, Kho, Kuan H, Driessen, Chantal M. L, Jeltema, Hanne-Rinck, Robe, Pierre A. J. T, Maas, Sybren L. N

“…Glioblastoma (GBM), the most common glial primary brain tumour, is without exception lethal. Every year approximately 600 patients are diagnosed with this…”
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Heparin in malignant glioma: review of preclinical studies and clinical results by Schnoor, Rosalie, Maas, Sybren L. N., Broekman, Marike L. D.

“…Glioblastoma multiforme (GBM) is the most common primary brain tumor that is invariably lethal. Novel treatments are desperately needed. In various cancers,…”
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True shared decision-making in neurosurgical oncology: does it really exist? by Jessurun, Charissa A. C., Broekman, Marike L. D.

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The endoscope-assisted supraorbital “keyhole” approach for anterior skull base meningiomas: an updated meta-analysis by Khan, Danyal Z., Muskens, Ivo S., Mekary, Rania A., Zamanipoor Najafabadi, Amir H., Helmy, Adel E., Reisch, Robert, Broekman, Marike L. D., Marcus, Hani J.

“…Introduction The gold-standard treatment for symptomatic anterior skull base meningiomas is surgical resection. The endoscope-assisted supraorbital “keyhole”…”
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Palliative Care in Severe Neurotrauma Patients in the Intensive Care Unit by Dolmans, Rianne G. F., Robertson, Faith C., Eijkholt, Marleen, van Vliet, Peter, Broekman, Marike L. D.

“…Traumatic brain injury (TBI) is a significant cause of mortality and morbidity worldwide and many patients with TBI require intensive care unit (ICU)…”
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Comparative Analysis Identifies Similarities between the Human and Murine Microglial Sensomes by Abels, Erik R, Nieland, Lisa, Hickman, Suzanne, Broekman, Marike L D, El Khoury, Joseph, Maas, Sybren L N

“…One of the essential functions of microglia is to continuously sense changes in their environment and adapt to those changes. For this purpose, they use a set…”
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Whole genome sequencing in (recurrent) glioblastoma: challenges related to informed consent procedures and data sharing by Hasner, Mira C., van Opijnen, Mark P., de Vos, Filip Y. F., Cuppen, Edwin, Broekman, Marike L. D.

“…Increased use of whole genome sequencing (WGS) in neuro-oncology for diagnostics and research purposes necessitates a renewed conversation about informed…”
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Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics by Maas, Sybren L.N., de Vrij, Jeroen, van der Vlist, Els J., Geragousian, Biaina, van Bloois, Louis, Mastrobattista, Enrico, Schiffelers, Raymond M., Wauben, Marca H.M., Broekman, Marike L.D., Nolte-'t Hoen, Esther N.M.

“…Nano-sized extracelullar vesicles (EVs) released by various cell types play important roles in a plethora of (patho)physiological processes and are…”
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Quantification and size-profiling of extracellular vesicles using tunable resistive pulse sensing by Maas, Sybren L N, De Vrij, Jeroen, Broekman, Marike L D

“…Extracellular vesicles (EVs), including 'microvesicles' and 'exosomes', are highly abundant in bodily fluids. Recent years have witnessed a tremendous increase…”
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Ethics in contemporary health care management and medical education by Balak, Naci, Broekman, Marike L.D., Mathiesen, Tiit

“…Rationale The health care landscape is changing: it has become the largest part of the economy and changes in public management systems will greatly affect how…”
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