Search Results - "Broekhuizen, Michelle"

Chronic Kidney Disease as a Risk Factor for Heart Failure With Preserved Ejection Fraction: A Focus on Microcirculatory Factors and Therapeutic Targets by van de Wouw, Jens, Broekhuizen, Michelle, Sorop, Oana, Joles, Jaap A., Verhaar, Marianne C., Duncker, Dirk J., Danser, A. H. Jan, Merkus, Daphne

“…Heart failure (HF) and chronic kidney disease (CKD) co-exist, and it is estimated that about 50% of HF patients suffer from CKD. Although studies have been…”
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Transplacental Zika virus transmission in ex vivo perfused human placentas by Langerak, Thomas, Broekhuizen, Michelle, Unger, Peter-Paul Alexander, Tan, Lunbo, Koopmans, Marion, van Gorp, Eric, Danser, A H Jan, Rockx, Barry

“…A Zika virus (ZIKV) infection during pregnancy can result in severe birth defects such as microcephaly. To date, it is incompletely understood how ZIKV can…”
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Megalin, Proton Pump Inhibitors and the Renin–Angiotensin System in Healthy and Pre-Eclamptic Placentas by Sun, Yuan, Tan, Lunbo, Neuman, Rugina I., Broekhuizen, Michelle, Schoenmakers, Sam, Lu, Xifeng, Danser, A. H. Jan

“…Soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in pre-eclampsia. The proton pump inhibitor (PPI) lowers sFlt-1, while angiotensin increases it. To…”
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The Placental Innate Immune System Is Altered in Early-Onset Preeclampsia, but Not in Late-Onset Preeclampsia by Broekhuizen, Michelle, Hitzerd, Emilie, van den Bosch, Thierry P P, Dumas, Jasper, Verdijk, Robert M, van Rijn, Bas B, Danser, A H Jan, van Eijck, Casper H J, Reiss, Irwin K M, Mustafa, Dana A M

“…Preeclampsia is a severe placenta-related pregnancy disorder that is generally divided into two subtypes named early-onset preeclampsia (onset <34 weeks of…”
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Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia by Hitzerd, Emilie, Broekhuizen, Michelle, Neuman, Rugina I, Colafella, Katrina M Mirabito, Merkus, Daphne, Schoenmakers, Sam, Simons, Sinno H P, Reiss, Irwin K M, Danser, A H Jan

“…Adequate development of the placenta is essential for optimal pregnancy outcome. Pre-eclampsia (PE) is increasingly recognized to be a consequence of placental…”
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Vasoactivity of cannabis components in human placental arteries by Harhangi, Madhavi, Simons, Sinno, Reiss, Irwin, Danser, Jan, Broekhuizen, Michelle

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Abstract 037: Serum Chemerin As A Novel Biomarker For Preeclampsia Complications: Effects Of Statins On Its Release From The Placenta by Tan, Lunbo, Broekhuizen, Michelle, Neuman, Rugina I., Schoenmakers, Sam, Lu, Xifeng, Danser, A.H. Jan, Verdonk, Koen

“…Abstract only Background: The adipokine chemerin is increased in preeclampsia (PE), possibly because it is released from the placenta. We aimed to evaluate the…”
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Immune profile alterations in SARS-CoV-2-infected placentas leading to fetal demise and placentas after COVID-19 vaccination during pregnancy by Broekhuizen, Michelle, van der Meeren, Lotte, Vadgama, Disha, Reiss, Irwin, Mustafa, Dana, Schoenmakers, Sam

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The endocannabinoid system and its vascular effect in healthy and preeclamptic placentas by Harhangi, Madhavi, Simons, Sinno, van Rijn, Bas, Schoenmakers, Sam, Reiss, Irwin, Danser, Jan, Broekhuizen, Michelle

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Flow-mediated vasodilation is impaired in placentas from women with preeclampsia by Broekhuizen, Michelle, Hitzerd, Emilie, Tan, Lunbo, Neuman, Rugina, Schoenmakers, Sam, Merkus, Daphne, Danser, Jan, Reiss, Irwin

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Fetoplacental vascular reactivity is altered in fetuses with congenital diaphragmatic hernia by Broekhuizen, Michelle, Horn-Oudshoorn, Emily, Harhangi, Madhavi, Simons, Sinno, Eggink, Alex, Danser, Jan, Reiss, Irwin, DeKoninck, Philip

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The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target? by Broekhuizen, Michelle, Danser, A. H. Jan, Reiss, Irwin K. M., Merkus, Daphne

“…(L-)tryptophan is metabolized via the kynurenine pathway into several kynurenine metabolites with distinct functions. Dysfunction of the kynurenine pathway can…”
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Pentoxifylline as a novel therapeutic option for preeclampsia by Broekhuizen, Michelle, Hitzerd, Emilie, de Vries, René, Merkus, Daphne, Danser, Jan, Reiss, Irwin, Simons, Sinno

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Placental transfer and metabolism of betamethasone in healthy and preeclamptic human placentas by Kluivers, Anna, Tan, Lunbo, van Zelst, Bertrand, van den Berg, Sjoerd, Simons, Sinno, Reiss, Irwin, Danser, Jan, Schoenmakers, Sam, Broekhuizen, Michelle

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STATINS PREVENT THE DELETERIOUS CONSEQUENCES OF PLACENTAL CHEMERIN UPREGULATION IN PREECLAMPSIA by Tan, Lunbo, Kluivers, Ans C.M., Cruz-lopez, Edwyn O., Broekhuizen, Michelle, Chen, Zhongli, Neuman, Rugina I., Schoenmakers, Sam, Ruijgrok, Liesbeth, Van De Velde, Daan, De Winter, Brenda C.M., Van Den Bogaerdt, Antoon J., Lu, Xifeng, Danser, A.H. Jan, Verdonk, Koen

“…Objective: Chemerin, an inflammatory adipokine, is upregulated in preeclampsia, and its placental overexpression results in preeclampsia-like symptoms in mice…”
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L-Tryptophan–Induced Vasodilation Is Enhanced in Preeclampsia: Studies on Its Uptake and Metabolism in the Human Placenta by Broekhuizen, Michelle, Klein, Theo, Hitzerd, Emilie, de Rijke, Yolanda B., Schoenmakers, Sam, Sedlmayr, Peter, Danser, A.H. Jan, Merkus, Daphne, Reiss, Irwin K.M.

“…L-tryptophan induces IDO (indoleamine 2,3-dioxygenase) 1–dependent vasodilation. IDO1 is expressed in placental endothelial cells and downregulated in…”
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Omeprazole Administration in Preterm Preeclampsia: a Randomized Controlled Trial to Study Its Effect on sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1), PlGF (Placental Growth Factor), and ET-1 (Endothelin-1) by Neuman, Rugina I., Baars, Milan D., Saleh, Langeza, Broekhuizen, Michelle, Nieboer, Daan, Cornette, Jérôme, Schoenmakers, Sam, Verhoeven, Michel, Koch, Birgit C.P., Russcher, Henk, van den Berg, Sjoerd A.A., van den Meiracker, Anton H., Visser, Willy, Danser, A.H. Jan

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Asymmetrical transport of thyroxine across human term placenta by Chen, Zhongli, Leeuwenburgh, Selmar, Broekhuizen, Michelle, Neuman, Rugina, Hitzerd, Emilie, Tan, Lunbo, Jongejan, Rutchanna, de Rijke, Yolanda, Reiss, Irwin, Visser, Edward, Danser, Jan, Meima, Marcel, Peteers, Robin

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The placental innate immune profile is altered in early onset-, but not late onset preeclampsia by Broekhuizen, Michelle, Hitzerd, Emilie, van den Bosch, Thierry, Verdijk, Robert, van Rijn, Bas, Danser, Jan, van Eijck, Casper, Reiss, Irwin, Mustafa, Dana

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Omeprazole Administration in Preterm Preeclampsia: a Randomized Controlled Trial to Study Its Effect on sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1), PlGF (Placental Growth Factor), and ET-1 (Endothelin-1) by Neuman, Rugina I., Baars, Milan D., Saleh, Langeza, Broekhuizen, Michelle, Nieboer, Daan, Cornette, Jérôme, Schoenmakers, Sam, Verhoeven, Michel, Koch, Birgit C.P., Russcher, Henk, van den Berg, Sjoerd A.A., van den Meiracker, Anton H., Visser, Willy, Danser, A.H. Jan

“…Low sFlt-1 (soluble Fms-like tyrosine kinase-1) and ET-1 (endothelin-1) levels have been reported in preeclamptic women using proton pump inhibitors. Here, we…”
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