Search Results - "Brodiazhenko, Tetiana"
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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis
Published in Molecular cell (05-08-2021)“…RelA-SpoT Homolog (RSH) enzymes control bacterial physiology through synthesis and degradation of the nucleotide alarmone (p)ppGpp. We recently discovered…”
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Elimination of Ribosome Inactivating Factors Improves the Efficiency of Bacillus subtilis and Saccharomyces cerevisiae Cell-Free Translation Systems
Published in Frontiers in microbiology (2018)“…Cell-free translation systems based on cellular lysates optimized for protein synthesis have multiple applications both in basic and applied science, ranging…”
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Synthetic oxepanoprolinamide iboxamycin is active against Listeria monocytogenes despite the intrinsic resistance mediated by VgaL/Lmo0919 ABCF ATPase
Published in JAC-antimicrobial resistance (01-06-2022)“…Abstract Background Listeriosis is a food-borne disease caused by the Gram-positive Bacillota (Firmicute) bacterium Listeria monocytogenes. Clinical L…”
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Direct activation of a bacterial innate immune system by a viral capsid protein
Published in Nature (London) (01-12-2022)“…Bacteria have evolved diverse immunity mechanisms to protect themselves against the constant onslaught of bacteriophages 1 – 3 . Similar to how eukaryotic…”
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Uncovering new families and folds in the natural protein universe
Published in Nature (London) (19-10-2023)“…We are now entering a new era in protein sequence and structure annotation, with hundreds of millions of predicted protein structures made available through…”
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A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains
Published in Proceedings of the National Academy of Sciences - PNAS (08-02-2022)“…Toxin-antitoxin (TA) gene pairs are ubiquitous in microbial chromosomal genomes and plasmids as well as temperate bacteriophages. They act as regulatory…”
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The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems
Published in Proceedings of the National Academy of Sciences - PNAS (15-08-2023)“…Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile genetic elements. Type II TAs are encoded as…”
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Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems
Published in Cell host & microbe (10-07-2024)“…Toxin-antitoxins (TAs) are prokaryotic two-gene systems composed of a toxin neutralized by an antitoxin. Toxin-antitoxin-chaperone (TAC) systems additionally…”
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