Search Results - "Brodeur, Peter H."

Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus by Perlot, Thomas, Pawlitzky, Inka, Manis, John P, Zarrin, Ali A, Brodeur, Peter H, Alt, Frederick W

“…The 5' end of the IgH locus contains a cluster of DNaseI hypersensitive sites, one of which (HS1) was shown to be pro-B cell specific and to contain binding…”
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Expansion of CD4 T cells expressing a highly restricted TCR structure specific for a single parasite epitope correlates with high pathology in murine schistosomiasis by Finger, Eduardo, Brodeur, Peter H., Hernandez, Hector J., Stadecker, Miguel J.

“…The hepatic immunopathology in schistosomiasis mansoni is mediated by CD4 T cells specific for egg antigens and varies considerably among mouse strains…”
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Identification of a Candidate Regulatory Element within the 5' Flanking Region of the Mouse Igh Locus Defined by Pro-B Cell-Specific Hypersensitivity Associated with Binding of PU.1, Pax5, and E2A by Pawlitzky, Inka, Angeles, Christina V, Siegel, Andrea M, Stanton, Michelle L, Riblet, Roy, Brodeur, Peter H

“…The Igh locus is controlled by cis-acting elements, including Emu and the 3' IgH regulatory region which flank the C region genes within the well-studied 3'…”
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Cutting Edge: Stat5 Mediates the IL-7-Induced Accessibility of a Representative D-Distal VH Gene by Stanton, Michelle L, Brodeur, Peter H

“…During B cell development, discrete domains within the Igh locus are activated independently for recombination. The D-distal VH genes are uniquely dependent on…”
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The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes by Brodeur, P H, Riblet, R

“…Seven families of Igh-V genes have been defined by Southern blot analysis of genomic DNA from eighteen inbred strains of mice. Each of twenty-four cloned Vh…”
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Stat5 Mediates the IL-7-Induced Accessibility of a Representative D-Distal V sub(H) Gene by Stanton, Michelle L, Brodeur, Peter H

“…During B cell development, discrete domains within the Igh locus are activated independently for recombination. The D-distal V sub(H) genes are uniquely…”
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Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene by Stanton, Michelle L, Brodeur, Peter H

“…During B cell development, discrete domains within the Igh locus are activated independently for recombination. The D-distal V(H) genes are uniquely dependent…”
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Accessibility changes across the mouse Igh‐V locus during B cell development by Haines, Brian B., Brodeur, Peter H.

“…During their development, B and T lymphocytes are thought to undergo several cycles of chromatin remodeling at their antigen receptor loci that serve to…”
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Germline diversity of the expressed BALB/c VhJ558 gene family by Haines, Brian B., Angeles, Christina V., Parmelee, Allen P., McLean, Paul A., Brodeur, Peter H.

“…Although the mouse immunoglobulin heavy chain ( Igh) locus contains 15 heavy chain V (Vh) gene families, at least half of the Vh gene segments are members of…”
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Rearrangement and Selection in the Developing Vκ Repertoire of the Mouse: An Analysis of the Usage of Two Vκ Gene Segments by Whitcomb, Elizabeth A., Brodeur, Peter H.

“…Detailed analysis of the rearrangement and expression of two mouse Vκ genes has been used to examine B cell repertoire development. The Vκ1-A gene is used by a…”
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Germline Structure and Differential Utilization of Igh a and Igh b VH10 Genes by Whitcomb, Elizabeth A., Haines, Brian B., Parmelee, Allen P., Pearlman, Adam M., Brodeur, Peter H.

“…Ab heavy chains encoded by mouse VH10 genes have been of particular interest due to their frequent association with DNA binding. We reported previously that…”
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Deletional mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes by Mainville, CA, Sheehan, KM, Klaman, LD, Giorgetti, CA, Press, JL, Brodeur, PH

“…In addition to the content of germ-line variable gene segments, the organization of V genes has been implicated in the development of the Ab repertoire. We…”
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Differential antigen recognition by T cell populations from strains of mice developing polar forms of granulomatous inflammation in response to eggs of Schistosoma mansoni by Hernandez, H J, Trzyna, W C, Cordingley, J S, Brodeur, P H, Stadecker, M J

“…In humans, infection with schistosome helminths can lead to dissimilar forms of clinical disease. Likewise, in the experimental mouse system, identical…”
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The organization of the mouse Igh-V locus: dispersion, interspersion, and the evolution of VH gene family clusters by BRODEUR, P. H, OSMAN, G. E, MACKLE, J. J, LALOR, T. M

“…We have constructed a panel of Abelson murine leukemia virus-transformed pre-B cells to study the organization of the mouse VH gene families. Based on the…”
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Utilization of V kappa families and V kappa exons. Implications for the available B cell repertoire by Kalled, SL, Brodeur, PH

“…A molecular cloning approach was used to determine the relative utilization of 2 individual V kappa 21 genes, 13 V kappa gene families, and the 4 functional J…”
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Germline Structure and Differential Utilization of Igha and Ighb VH10 Genes by Whitcomb, Elizabeth A, Haines, Brian B, Parmelee, Allen P, Pearlman, Adam M, Brodeur, Peter H

“…Ab heavy chains encoded by mouse VH10 genes have been of particular interest due to their frequent association with DNA binding. We reported previously that…”
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Organization and expression of VH gene families preferentially expressed by Ly-1+ (CD5) B cells by Pennell, C A, Sheehan, K M, Brodeur, P H, Clarke, S H

“…Previously we have shown that a high proportion (5%-15%) of peritoneal Ly-1+ B cells that bind the common membrane phospholipid, phosphatidylcholine, express…”
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The utilization of individual VH exons in the primary repertoire of adult BALB/c mice by Sheehan, KM, Mainville, CA, Willert, S, Brodeur, PH

“…The utilization of VH gene families is severely biased during fetal development, such that D-region proximal VH genes are overrepresented. After birth the VH…”
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Rearrangement and Selection in the Developing V{kappa} Repertoire of the Mouse: An Analysis of the Usage of Two V{kappa} Gene Segments by Whitcomb, Elizabeth A, Brodeur, Peter H

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The cell-mediated response to schistosomal antigens at the clonal level: development and characterization of a panel of egg antigen-specific murine T cell clones by Chikunguwo, S M, Harris, T S, Brodeur, P H, Harn, D A, Stadecker, M J

“…The cellular basis of the immune response underlying the granulomatous hypersensitivity in experimental murine schistosomiasis caused by Schistosoma mansoni…”
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