Search Results - "Brodeur, Anne M"

cis-2,5-Dicyanopyrrolidine Inhibitors of Dipeptidyl Peptidase IV:  Synthesis and in Vitro, in Vivo, and X-ray Crystallographic Characterization by Wright, Stephen W, Ammirati, Mark J, Andrews, Kim M, Brodeur, Anne M, Danley, Dennis E, Doran, Shawn D, Lillquist, Jay S, McClure, Lester D, McPherson, R. Kirk, Orena, Stephen J, Parker, Janice C, Polivkova, Jana, Qiu, Xiayang, Soeller, Walter C, Soglia, Carolyn B, Treadway, Judith L, VanVolkenburg, Maria A, Wang, Hong, Wilder, Donald C, Olson, Thanh V

“…Inhibitors of the glucagon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2…”
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3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor by Ammirati, Mark J, Andrews, Kim M, Boyer, David D, Brodeur, Anne M, Danley, Dennis E, Doran, Shawn D, Hulin, Bernard, Liu, Shenping, McPherson, R Kirk, Orena, Stephen J, Parker, Janice C, Polivkova, Jana, Qiu, Xiayang, Soglia, Carolyn B, Treadway, Judith L, VanVolkenburg, Maria A, Wilder, Donald C, Piotrowski, David W

“…A series of 4-substituted proline amides was synthesized and evaluated as inhibitors of dipeptidyl pepdidase IV for the treatment of type 2 diabetes…”
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(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization by Wright, Stephen W., Ammirati, Mark J., Andrews, Kim M., Brodeur, Anne M., Danley, Dennis E., Doran, Shawn D., Lillquist, Jay S., Liu, Shenping, McClure, Lester D., McPherson, R. Kirk, Olson, Thanh V., Orena, Stephen J., Parker, Janice C., Rocke, Benjamin N., Soeller, Walter C., Soglia, Carolyn B., Treadway, Judith L., VanVolkenburg, Maria A., Zhao, Zhengrong, Cox, Eric D.

“…Potency, selectivity, and pharmacokinetic properties of DPP-IV inhibitors developed from a HTS hit were optimized resulting in the identification of a…”
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3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor by Ammirati, Mark J., Andrews, Kim M., Boyer, David D., Brodeur, Anne M., Danley, Dennis E., Doran, Shawn D., Hulin, Bernard, Liu, Shenping, McPherson, R. Kirk, Orena, Stephen J., Parker, Janice C., Polivkova, Jana, Qiu, Xiayang, Soglia, Carolyn B., Treadway, Judith L., VanVolkenburg, Maria A., Wilder, Donald C., Piotrowski, David W.

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(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone : A potent, selective, orally active dipeptidyl peptidase IV inhibitor by AMMIRATI, Mark J, ANDREWS, Kim M, PARKER, Janice C, POLIVKOVA, Jana, XIAYANG QIU, SOGLIA, Carolyn B, TREADWAY, Judith L, VANVOLKENBURG, Maria A, WILDER, Donald C, PIOTROWSKI, David W, BOYER, David D, BRODEUR, Anne M, DANLEY, Dennis E, DORAN, Shawn D, HULIN, Bernard, SHENPING LIU, KIRK MCPHERSON, R, ORENA, Stephen J

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