Search Results - "Broderick, Ronan"

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells by Lai, Xianning, Broderick, Ronan, Bergoglio, Valérie, Zimmer, Jutta, Badie, Sophie, Niedzwiedz, Wojciech, Hoffmann, Jean-Sébastien, Tarsounas, Madalena

“…Failure to restart replication forks stalled at genomic regions that are difficult to replicate or contain endogenous DNA lesions is a hallmark of BRCA2…”
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Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2’s nuclease activity by Broderick, Ronan, Cherdyntseva, Veronica, Nieminuszczy, Jadwiga, Dragona, Eleni, Kyriakaki, Maria, Evmorfopoulou, Theodora, Gagos, Sarantis, Niedzwiedz, Wojciech

“…Telomerase-independent cancer proliferation via the alternative lengthening of telomeres (ALT) relies upon two distinct, largely uncharacterized,…”
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Correction: Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells by Lai, Xianning, Broderick, Ronan, Bergoglio, Valérie, Zimmer, Jutta, Badie, Sophie, Niedzwiedz, Wojciech, Hoffmann, Jean-Sébastien, Tarsounas, Madalena

“…Nature Communications 8: Article number: 15983 (2017); Published: 17 July 2017; Updated: 26 October 2017 In this Article, there are errors in the labelling of…”
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Regulation of Cdc45 in the cell cycle and after DNA damage by Broderick, Ronan, Nasheuer, Heinz-Peter

“…The Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA…”
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Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy by Broderick, Ronan, Ramadurai, Sivaramakrishnan, Tóth, Katalin, Togashi, Denisio M, Ryder, Alan G, Langowski, Jörg, Nasheuer, Heinz Peter

“…Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by…”
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Sister chromatid decatenation: bridging the gaps in our knowledge by Broderick, Ronan, Niedzwiedz, Wojciech

“…Faithful chromosome segregation is critical in preventing genome loss or damage during cell division. Failure to properly disentangle catenated sister…”
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TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution by Broderick, Ronan, Nieminuszczy, Jadwiga, Blackford, Andrew N., Winczura, Alicja, Niedzwiedz, Wojciech

“…During mitosis, sister chromatids must be faithfully segregated to ensure that daughter cells receive one copy of each chromosome. However, following…”
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EXD2 - a new player joins the DSB resection team by Nieminuszczy, Jadwiga, Broderick, Ronan, Niedzwiedz, Wojciech

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Actin nucleators safeguard replication forks by limiting nascent strand degradation by Nieminuszczy, Jadwiga, Martin, Peter R, Broderick, Ronan, Krwawicz, Joanna, Kanellou, Alexandra, Mocanu, Camelia, Bousgouni, Vicky, Smith, Charlotte, Wen, Kuo-Kuang, Woodward, Beth L, Bakal, Chris, Shackley, Fiona, Aguilera, Andrés, Stewart, Grant S, Vyas, Yatin M, Niedzwiedz, Wojciech

“…Abstract Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to…”
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SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response by Bland, Philip, Saville, Harry, Wai, Patty T., Curnow, Lucinda, Muirhead, Gareth, Nieminuszczy, Jadwiga, Ravindran, Nivedita, John, Marie Beatrix, Hedayat, Somaieh, Barker, Holly E., Wright, James, Yu, Lu, Mavrommati, Ioanna, Read, Abigail, Peck, Barrie, Allen, Mark, Gazinska, Patrycja, Pemberton, Helen N., Gulati, Aditi, Nash, Sarah, Noor, Farzana, Guppy, Naomi, Roxanis, Ioannis, Pratt, Guy, Oldreive, Ceri, Stankovic, Tatjana, Barlow, Samantha, Kalirai, Helen, Coupland, Sarah E., Broderick, Ronan, Alsafadi, Samar, Houy, Alexandre, Stern, Marc-Henri, Pettit, Stephen, Choudhary, Jyoti S., Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J., Natrajan, Rachael

“…SF3B1 hotspot mutations are associated with a poor prognosis in several tumor types and lead to global disruption of canonical splicing. Through synthetic…”
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SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance by Llorca-Cardenosa, Marta J, Aronson, Lauren I, Krastev, Dragomir B, Nieminuszczy, Jadwiga, Alexander, John, Song, Feifei, Dylewska, Malgorzata, Broderick, Ronan, Brough, Rachel, Zimmermann, Astrid, Zenke, Frank T, Gurel, Bora, Riisnaes, Ruth, Ferreira, Ana, Roumeliotis, Theodoros, Choudhary, Jyoti, Pettitt, Stephen J, de Bono, Johann, Cervantes, Andres, Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J, Chong, Irene Y

“…Gastric cancer represents the third leading cause of global cancer mortality and an area of unmet clinical need. Drugs that target the DNA damage response,…”
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EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2 by Nieminuszczy, Jadwiga, Broderick, Ronan, Bellani, Marina A., Smethurst, Elizabeth, Schwab, Rebekka A., Cherdyntseva, Veronica, Evmorfopoulou, Theodora, Lin, Yea-Lih, Minczuk, Michal, Pasero, Philippe, Gagos, Sarantis, Seidman, Michael M., Niedzwiedz, Wojciech

“…Accurate DNA replication is essential to preserve genomic integrity and prevent chromosomal instability-associated diseases including cancer. Key to this…”
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Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells by Lai, Xianning, Broderick, Ronan, Bergoglio, Valérie, Zimmer, Jutta, Badie, Sophie, Niedzwiedz, Wojciech, Hoffmann, Jean-Sébastien, Tarsounas, Madalena

“…This corrects the article DOI: 10.1038/ncomms15983…”
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EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2 by Nieminuszczy, Jadwiga, Broderick, Ronan, Bellani, Marina A, Smethurst, Elizabeth, Schwab, Rebekka A, Cherdyntseva, Veronica, Evmorfopoulou, Theodora, Lin, Yea-Lih, Minczuk, Michal, Pasero, Philippe, Gagos, Sarantis, Seidman, Michael M, Niedzwiedz, Wojciech

“…Highlights d EXD2 is required for cell survival in response to replicative stress d EXD2 protects replication forks from over resection by counteracting fork…”
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Cell cycle‐dependent formation of Cdc45–Claspin complexes in human cells is compromized by UV‐mediated DNA damage by Broderick, Ronan, Rainey, Michael D., Santocanale, Corrado, Nasheuer, Heinz P.

“…The replication factor Cdc45 has essential functions in the initiation and elongation steps of eukaryotic DNA replication and plays an important role in the…”
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EXD2 promotes homologous recombination by facilitating DNA end resection by Broderick, Ronan, Nieminuszczy, Jadwiga, Baddock, Hannah T., Deshpande, Rajashree A., Gileadi, Opher, Paull, Tanya T., McHugh, Peter J., Niedzwiedz, Wojciech

“…Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is critical for survival and genome stability of individual cells and organisms, but…”
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Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition by Bland, Phil, Saville, Harry, Read, Abigail, Wai, Patty, Muirhead, Gareth, Curnow, Lucinda, Nieminuszczy, Jadwiga, Ravindran, Nivedita, John, Marie, Hedayat, Somaieh, Barker, Holly, Wright, James, Yu, Lu, Mavrommati, Ioanna, Peck, Barrie, Allen, Mark, Gazinska, Patrycja, Pemberton, Helen, Gulati, Aditi, Nash, Sarah, Noor, Farzana, Guppy, Naomi, Roxanis, Ioannis, Barlow, Samantha, Kalirai, Helen, Coupland, Sarah, Broderick, Ronan, Alsafadi, Samar, Houy, Alexandre, Stern, Marc-Henri, Pettit, Stephen, Choudhary, Jyoti, Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher, Natrajan, Rachael

“…Abstract Background: Heterozygous hotspot mutations in the RNA splicing factor SF3B1, occur in 3% of unselected breast cancers and are associated with…”
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