Search Results - "Broderick, Joan B."

The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies by Yang, Hao, McDaniel, Elizabeth C, Impano, Stella, Byer, Amanda S, Jodts, Richard J, Yokoyama, Kenichi, Broderick, William E, Broderick, Joan B, Hoffman, Brian M

“…The 5′-deoxyadenosyl radical (5′-dAdo·) abstracts a substrate H atom as the first step in radical-based transformations catalyzed by…”
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Emerging Paradigms for Complex Iron-Sulfur Cofactor Assembly and Insertion by Peters, John W, Broderick, Joan B

“…[FeFe]-hydrogenses and molybdenum (Mo)-nitrogenase are evolutionarily unrelated enzymes with unique complex iron-sulfur cofactors at their active sites. The H…”
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Insights into [FeFe]-Hydrogenase Structure, Mechanism, and Maturation by Mulder, David W., Shepard, Eric M., Meuser, Jonathan E., Joshi, Neelambari, King, Paul W., Posewitz, Matthew C., Broderick, Joan B., Peters, John W.

“…Hydrogenases are metalloenzymes that are key to energy metabolism in a variety of microbial communities. Divided into three classes based on their metal…”
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The antiviral protein viperin is a radical SAM enzyme by Duschene, Kaitlin S., Broderick, Joan B.

“…Viperin, an interferon-inducible antiviral protein, is shown to bind an iron-sulfur cluster, based on iron analysis as well as UV–Vis and electron paramagnetic…”
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Pyruvate Formate-lyase and Its Activation by Pyruvate Formate-lyase Activating Enzyme by Crain, Adam V., Broderick, Joan B.

“…The activation of pyruvate formate-lyase (PFL) by pyruvate formate-lyase activating enzyme (PFL-AE) involves formation of a specific glycyl radical on PFL by…”
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Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free by Horitani, Masaki, Byer, Amanda S, Shisler, Krista A, Chandra, Tilak, Broderick, Joan B, Hoffman, Brian M

“…Lysine 2,3-aminomutase (LAM) is a radical S-adenosyl-l-methionine (SAM) enzyme and, like other members of this superfamily, LAM utilizes radical-generating…”
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[FeFe]-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine by Driesener, Rebecca C, Challand, Martin R, McGlynn, Shawn E, Shepard, Eric M, Boyd, Eric S, Broderick, Joan B, Peters, John W, Roach, Peter L

“…What's your poison? Hydrogenases catalyze the reversible formation of dihydrogen from two electrons and two protons. The maturation of the [FeFe]‐hydrogenase…”
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Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme by Vey, Jessica L, Yang, Jian, Li, Meng, Broderick, William E, Broderick, Joan B, Drennan, Catherine L

“…Pyruvate formate-lyase activating enzyme generates a stable and catalytically essential glycyl radical on G⁷³⁴ of pyruvate formate-lyase via the direct,…”
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Biosynthesis of complex iron–sulfur enzymes by Shepard, Eric M, Boyd, Eric S, Broderick, Joan B, Peters, John W

“…Recent advances in our understanding of the mechanisms for the biosynthesis of the complex iron–sulfur (Fe–S) containing prosthetic groups associated with…”
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Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold by Shepard, Eric M, McGlynn, Shawn E, Bueling, Alexandra L, Grady-Smith, Celestine S, George, Simon J, Winslow, Mark A, Cramer, Stephen P, Peters, John W, Broderick, Joan B

“…The organometallic H cluster at the active site of [FeFe]-hydrogenase consists of a 2Fe subcluster coordinated by cyanide, carbon monoxide, and a nonprotein…”
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Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis by Adelson, Charles N, Johnston, Esther M, Hilmer, Kimberly M, Watts, Hope, Dey, Somdatta Ghosh, Brown, Doreen E, Broderick, Joan B, Shepard, Eric M, Dooley, David M, Solomon, Edward I

“…Copper-dependent amine oxidases produce their redox active cofactor, 2,4,5-trihydroxyphenylalanine quinone (TPQ), via the CuII-catalyzed oxygenation of an…”
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EPR and FTIR Analysis of the Mechanism of H2 Activation by [FeFe]-Hydrogenase HydA1 from Chlamydomonas reinhardtii by Mulder, David W, Ratzloff, Michael W, Shepard, Eric M, Byer, Amanda S, Noone, Seth M, Peters, John W, Broderick, Joan B, King, Paul W

“…While a general model of H2 activation has been proposed for [FeFe]-hydrogenases, the structural and biophysical properties of the intermediates of the…”
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Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction by Kim, Sang-Hoon, Harzman, Christina, Davis, John K, Hutcheson, Rachel, Broderick, Joan B, Marsh, Terence L, Tiedje, James M

“…The genome of the Gram-positive, metal-reducing, dehalorespiring Desulfitobacterium hafniense DCB-2 was sequenced in order to gain insights into its metabolic…”
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A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in Methanosarcina barkeri by Fausset, Hunter, Spietz, Rachel L, Cox, Savannah, Cooper, Gwendolyn, Spurzem, Scott, Tokmina-Lukaszewska, Monika, DuBois, Jennifer, Broderick, Joan B, Shepard, Eric M, Boyd, Eric S, Bothner, Brian

“…Iron (Fe) and sulfur (S) are required elements for life, and changes in their availability can limit the ecological distribution and function of…”
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Unraveling the secrets of radical SAM mechanisms by Broderick, Joan B.

“…Radical SAM enzymes catalyze a remarkable diversity of biological radical reactions using a common radical initiation mechanism involving a [4Fe‐4S] cluster…”
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HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis by McGlynn, Shawn E., Shepard, Eric M., Winslow, Mark A., Naumov, Anatoli V., Duschene, Kaitlin S., Posewitz, Matthew C., Broderick, William E., Broderick, Joan B., Peters, John W.

“…In an effort to determine the specific protein component(s) responsible for in vitro activation of the [FeFe] hydrogenase (HydA), the individual maturation…”
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Radical S‑Adenosylmethionine Enzymes by Broderick, Joan B, Duffus, Benjamin R, Duschene, Kaitlin S, Shepard, Eric M

“…Broderick et al investigate radical s-adenosylmethionine (SAM) enzymes and detail their biochemical, structural and mechanistic elements. Strong reducing…”
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Characterization of an Active Spore Photoproduct Lyase, a DNA Repair Enzyme in the Radical S-Adenosylmethionine Superfamily by Buis, Jeffrey M., Cheek, Jennifer, Kalliri, Efthalia, Broderick, Joan B.

“…The major photoproduct in UV-irradiated Bacillus spore DNA is a unique thymine dimer called spore photoproduct (SP, 5-thyminyl-5,6-dihydrothymine). The enzyme…”
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Mechanism of Radical Initiation in the Radical S‑Adenosyl‑l‑methionine Superfamily by Broderick, William E, Hoffman, Brian M, Broderick, Joan B

“…Conspectus The seeds for recognition of the vast superfamily of radical S-adenosyl-l-methionine (SAM) enzymes were sown in the 1960s, when Joachim Knappe found…”
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Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor by MCGLYNN, Shawn E, BOYD, Eric S, SHEPARD, Eric M, LANGE, Rachel K, GERLACH, Robin, BRODERICK, Joan B, PETERS, John W

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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