Search Results - "Brockman, R. Wallace"

Effects of 2-chloro-9-(3-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate by PARKER, W. B, SHADDIX, S. C, CHI-HSIUNG CHANG, WHITE, E. L, ROSE, L. M, BROCKMAN, R. W, SHORTNACY, A. T, MONTGOMERY, J. A, SECRIST, J. A, LEE BENNETT, L. JR

“…2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-adenine (Cl-F-ara-A) has activity against the P388 tumor in mice on several different schedules…”
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Reactive 5'-substituted 2',5'-dideoxyuridine derivatives as potential inhibitors of nucleotide biosynthesis by Elliott, Robert D, Pruett, Pamela S, Brockman, R. Wallace, Montgomery, John A

“…5'-(Bromoacetamido)-2',5'-dideoxyuridine (3) and derivatives (8, 10, 12, and 14) substituted at the 5-position with bromo, iodo, fluoro, and ethyl groups have…”
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Nitrosoureido nucleosides as potential inhibitors of nucleotide biosynthesis by Elliott, Robert D, Thomas, H. Jeanette, Shaddix, Sue C, Adamson, Doris J, Brockman, R. Wallace, Riordan, James M, Montgomery, John A

“…Several nitrosoureido nucleosides (3a, 3b, 5a, 7a, 7c, and 10a) designed as inhibitors of enzymes that metabolize pyrimidine nucleotides have been prepared and…”
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Isolation and characterization of epithelial cell types from the normal rat colon by Chopra, D P, Yeh, K, Brockman, R W

“…Populations enriched in proliferative, mucous goblet, and absorptive cells were isolated by a method of repeated time dissociation of the colonic mucosa from…”
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Potential inhibitors of nucleotide biosynthesis. 1. Nitrosoureidonucleosides. 2 by Montgomery, John A, Thomas, H. Jeanette, Brockman, R. Wallace, Wheeler, Glynn P

“…Several nitrosoureidonucleosides (9a, 9b, 11a, 11b, 18 and 20) designed as inhibitors of enzymes that metabolize purine and pyrimidine nucleotides have been…”
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Nucleosides containing chemically reactive groups by Elliott, Robert D, Brockman, R. Wallace, Montgomery, John A

“…5'-Amino-5'-deoxyinosine (1) and 1-(6-amino-2,5,6-trideoxy-beta-D-erythro-hexofuranosyl)thymine (9) were prepared and substituted on the amino group with…”
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Comparison of the actions of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 9-beta-D-arabinofuranosyladenine on target enzymes from mouse tumor cells by White, E L, Shaddix, S C, Brockman, R W, Bennett, Jr, L L

“…9-beta-D-Arabinofuranosyl-2-fluoroadenine (2-F-ara-A), a derivative of 9-beta-D-arabinofuranosyladenine (ara-A) that is resistant to deamination, selectively…”
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Kinetic studies of adenosine kinase from L1210 cells: a model enzyme with a two-site ping-pong mechanism by Chang, Chi Hsiung, Cha, Sungman, Brockman, R. Wallace, Bennett, L. Lee

“…Purified adenosine kinase from L1210 cells displayed substrate inhibition by high concentrations of adenosine (Ado), ATP, and MgCl2. When incubated with ATP…”
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Alterations in nucleotide pools induced by 3-deazaadenosine and related compounds. Role of adenylate deaminase by Bennett, Jr, L L, Brockman, R W, Allan, P W, Rose, L M, Shaddix, S C

“…3-Deazaadenine, 3-deazaadenosine, and the carbocyclic analog of 3-deazaadenosine produced similar effects on nucleotide pools of L1210 cells in culture: each…”
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alpha.-(N)-Formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity by French, Frederic A, Blanz, Erwin J, Shaddix, Sue C, Brockman, R. Wallace

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Reactive 5'-substituted thymidine derivatives as potential inhibitors of nucleotide biosynthesis by Elliott, Robert D, Brockman, R. Wallace, Montgomery, John A

“…Fourteen derivatives of thymidine substituted at the 5'-position with haloacetamido (2-4), 2- and 3-bromopropionamido (5 and 6), bromoacetoxy (7),…”
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5-Amino-4-(diazoacetyl)-1-.beta.-D-ribofuranosylimidazole, a new antileukemic agent by Thomas, H. Jeanette, Avery, Lisa N, Brockman, R. Wallace, Montgomery, John A

“…5-Amino-4-(diazoacetyl)-1-beta-D-ribofuranosylimidazole (15), 5-amino-4-(chloroacetyl)-1-beta-D-ribofuranosylimidazole (16), and a number of related imidazole…”
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Cross-resistance of drug-resistant murine leukemias to deoxyspergualin (NSC 356894) in vivo by Harrison, Jr, S D, Brockman, R W, Trader, M W, Laster, Jr, W R, Griswold, Jr, D P

“…Deoxyspergualin, the 15-deoxy derivative of the antibiotic spergualin, is a novel guanidino analog structurally related to spermine. Deoxyspergualin has…”
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Purification and some properties of a deoxyribonucleoside kinase from L1210 cells by Chang, C H, Brockman, R W, Bennett, Jr, L L

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Potential inhibitors of nucleotide biosynthesis. 2. Halomethyl ketone derivatives of pyrimidine nucleosides by Montgomery, John A, Thomas, H. Jeanette, Brockman, R. Wallace, Elliott, Robert D

“…Several halomethyl ketone derivatives of pyrimidine nucleosides have been prepared for evaluation as cytotoxic agents. The first series are 1-(8-halo-2,5,6,8-…”
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Identification of metabolites of 9-beta-D-arabinofuranosyl-2-fluoroadenine, an antitumor and antiviral agent by Struck, R F, Shortnacy, A T, Kirk, M C, Thorpe, M C, Brockman, R W, Hill, D L, El Dareer, S M, Montgomery, J A

“…Analysis of blood from a dog given a 400 mg/m2 dose of 9-beta-D-arabinofuranosyl-2-fluoroadenine (2-F-araA) led to the identification of parent drug and a…”
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5'-Haloacetamido-5'-deoxythymidines: novel inhibitors of thymidylate synthase by Sani, B P, Vaid, A, Cory, J G, Brockman, R W, Elliott, R D, Montgomery, J A

“…5'-Bromoacetamido-5'-deoxythymidine (BAT), 5'-iodoacetamido-5'-deoxythymidine (IAT), 5'-chloroacetamido-5'-deoxythymidine (CAT) and [14C]BAT were synthesized…”
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Carbocyclic analogs of 5-fluorouracil nucleosides by Shealy, Y. Fulmer, Frye, Jerry L, DuBois, Nancy F, Shaddix, Sue C, Brockman, R. Wallace

“…The carbocyclic analogues of 5-fluoro-2'-deoxyuridine (5-FdUrd, 1), 5-fluorouridine, and 5-fluoro-3 alpha-deoxyuridine were prepared by fluorination of the…”
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A convenient procedure for purification of thymidylate synthase from L1210 cells by Banerjee, C K, Bennett, Jr, L L, Brockman, R W, Sani, B P, Temple, Jr, C

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Retinoic acid-binding protein in experimental and human colon tumors by Sani, B P, Condon, S M, Brockman, R W, Weiland, L H, Schutt, A J

“…Retinoic acid-binding protein is present in metastatic murine colon tumors as well as in Lewis lung tumors and in lungs and brains of mice bearing these…”
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