Search Results - "Brockman, R."

Chimeric antigen receptor T cell therapies for multiple myeloma by Wu, Chao, Zhang, Lina, Brockman, Qierra R, Zhan, Fenghuang, Chen, Lijuan

“…Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable despite the advent of numerous new drugs such as proteasome…”
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Discrepancies in indel software resolution with somatic CRISPR/Cas9 tumorigenesis models by Brockman, Qierra R., Scherer, Amanda, McGivney, Gavin R., Gutierrez, Wade R., Rytlewski, Jeffrey, Sheehan, Alexa, Warrier, Akshaya, Laverty, Emily A., Roughton, Grace, Carnevale, Nina C., Knepper-Adrian, Vickie, Dodd, Rebecca D.

“…CRISPR/Cas9 gene editing has evolved from a simple laboratory tool to a powerful method of in vivo genomic engineering. As the applications of CRISPR/Cas9…”
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Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models by Gutierrez, Wade R., Scherer, Amanda, McGivney, Gavin R., Brockman, Qierra R., Knepper-Adrian, Vickie, Laverty, Emily A., Roughton, Grace A., Dodd, Rebecca D.

“…Immune cells play critical functions in cancer, and mice with intact immune systems are vital to understanding tumor immunology. Both genetically engineered…”
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Establishment and characterization of a telomerase immortalized human gingival epithelial cell line by Moffatt-Jauregui, C. E., Robinson, B., de Moya, A. V., Brockman, R. D., Roman, A. V., Cash, M. N., Culp, D. J., Lamont, R. J.

“…Background and Objective Gingival keratinocytes are used in model systems to investigate the interaction between periodontal bacteria and the epithelium in the…”
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Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma by Gutierrez, Wade R, Rytlewski, Jeffrey D, Scherer, Amanda, Roughton, Grace A, Carnevale, Nina C, Vyas, Krisha Y, McGivney, Gavin R, Brockman, Qierra R, Knepper-Adrian, Vickie, Dodd, Rebecca D

“…Rhabdomyosarcoma (RMS) is an aggressive form of cancer that accounts for half of all pediatric soft tissue sarcomas. Little progress has been made in improving…”
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Physical activity by stealth? The potential health benefits of a workplace transport plan by Brockman, R, Fox, K.R

“…Summary Objectives There are few published evaluations of the effects of travel policy on health-enhancing physical activity. The purpose of this study was to…”
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Physically active families - de-bunking the myth? A qualitative study of family participation in physical activity by Thompson, J. L., Jago, R., Brockman, R., Cartwright, K., Page, A. S., Fox, K. R.

“…Background  The benefits of physical activity for reducing obesity and related chronic diseases are well known. The need for more family‐based interventions to…”
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Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma by Bochkov, Y A, Hanson, K M, Keles, S, Brockman-Schneider, R A, Jarjour, N N, Gern, J E

“…Rhinovirus (RV) infections trigger asthma exacerbations. Genome-wide expression analysis of RV1A-infected primary bronchial epithelial cells from normal and…”
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Calcinosis cutis arising in morphea: a case series by Brockman, R, Wills, A, Greiling, TM, Leitenberger, S, Fett, N

“…Calcinosis cutis, although common in systemic sclerosis, has been rarely reported in patients with morphea. We describe four patients with calcinosis cutis…”
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NAP SACC UK: protocol for a feasibility cluster randomised controlled trial in nurseries and at home to increase physical activity and healthy eating in children aged 2–4 years by Kipping, R, Jago, R, Metcalfe, C, White, J, Papadaki, A, Campbell, R, Hollingworth, W, Ward, D, Wells, S, Brockman, R, Nicholson, A, Moore, L

“…IntroductionSystematic reviews have identified the lack of intervention studies with young children to prevent obesity. This feasibility study examines the…”
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A Data Analytics Approach to Discovering Unique Microstructural Configurations Susceptible to Fatigue by Jha, S. K., Brockman, R. A., Hoffman, R. M., Sinha, V., Pilchak, A. L., Porter, W. J., Buchanan, D. J., Larsen, J. M., John, R.

“…Principal component analysis and fuzzy c -means clustering algorithms were applied to slip-induced strain and geometric metric data in an attempt to discover…”
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PRC2 loss drives MPNST metastasis and matrix remodeling by Brockman, Qierra R, Scherer, Amanda, McGivney, Gavin R, Gutierrez, Wade R, Voigt, Andrew P, Isaacson, Alexandra L, Laverty, Emily A, Roughton, Grace, Knepper-Adrian, Vickie, Darbro, Benjamin, Tanas, Munir R, Stipp, Christopher S, Dodd, Rebecca D

“…The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent…”
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Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism by Gutierrez, Wade R, Scherer, Amanda, Rytlewski, Jeffrey D, Laverty, Emily A, Sheehan, Alexa P, McGivney, Gavin R, Brockman, Qierra R, Knepper-Adrian, Vickie, Roughton, Grace A, Quelle, Dawn E, Gordon, David J, Monga, Varun, Dodd, Rebecca D

“…The DNA methyltransferase inhibitor decitabine has classically been used to reactivate silenced genes and as a pretreatment for anticancer therapies. In a…”
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Bankfull Regional Curves for the Inner and Outer Bluegrass Regions of Kentucky by Brockman, Ruth R., Agouridis, Carmen T., Workman, Stephen R., Ormsbee, Lindell E., Fogle, Alex W.

“…Bankfull regional curves that relate channel dimensions and discharge to watershed drainage area are useful tools for assisting in the correct identification…”
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Modelling Strategies for Property Identification Based on Full-Field Surface Displacement Data by Phillips, P. L., Brockman, R. A., John, R.

“…:  The use of full‐field displacement measurements in mechanical testing provides detailed response information that can be used, in conjunction with modelling…”
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Three-dimensional analysis of the interaction between a matrix crack and nanofiber by Gawandi, A.A., Whitney, J.M., Tandon, G.P., Brockman, R.B.

“…A three-dimensional study of interactions between a matrix crack and nanofibers is undertaken. The nanofibers considered in the study have a hollow structure…”
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Natural boundary conditions in the bending of anisotropic laminated plates by Gawandi, Anis, Whitney, J.M., Brockman, R.A.

“…Natural boundary conditions in the bending of anisotropic plates can never be exactly satisfied by a solution in a variables separable form. This creates…”
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CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression by Kohlmeyer, Jordan L, Lingo, Joshua J, Kaemmer, Courtney A, Scherer, Amanda, Warrier, Akshaya, Voigt, Ellen, Raygoza Garay, Juan A, McGivney, Gavin R, Brockman, Qierra R, Tang, Amy, Calizo, Ana, Pollard, Kai, Zhang, Xiaochun, Hirbe, Angela C, Pratilas, Christine A, Leidinger, Mariah, Breheny, Patrick, Chimenti, Michael S, Sieren, Jessica C, Monga, Varun, Tanas, Munir R, Meyerholz, David K, Darbro, Benjamin W, Dodd, Rebecca D, Quelle, Dawn E

“…Malignant peripheral nerve sheath tumors (MPNST) are lethal, Ras-driven sarcomas that lack effective therapies. We investigated effects of targeting…”
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Dynamic characterization of compliant materials using an all-polymeric split Hopkinson bar by SAWAS, O, BRAR, N. S, BROCKMAN, R. A

“…The split Hopkinson bar is a reliable experimental technique for measuring high strain rate properties of high-strength materials. Attempts to apply the split…”
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Singular stress fields near contact boundaries in a composite bolted joint by Whitney, T.J., Iarve, E.V., Brockman, R.A.

“…Singular stresses arising in the neighborhood of contact surfaces introduced in laminated orthotropic plates by mechanical joining with clamp-up were…”
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