Search Results - "Brockman, H"

Lipid monolayers: why use half a membrane to characterize protein-membrane interactions? by Brockman, Howard

“…Variants of membrane-active proteins and peptides are increasingly available through synthesis and molecular engineering. When determining the effects of…”
Get full text

Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum by Anderson, T J, Haubold, B, Williams, J T, Estrada-Franco, J G, Richardson, L, Mollinedo, R, Bockarie, M, Mokili, J, Mharakurwa, S, French, N, Whitworth, J, Velez, I D, Brockman, A H, Nosten, F, Ferreira, M U, Day, K P

“…Multilocus genotyping of microbial pathogens has revealed a range of population structures, with some bacteria showing extensive recombination and others…”
Get full text

A Phase 1 Study of the Proteasome Inhibitor Bortezomib in Pediatric Patients with Refractory Leukemia: a Children's Oncology Group Study by HORTON, Terzah M, PATI, Debananda, BLANEY, Susan M, PLON, Sharon E, THOMPSON, Patrick A, BOMGAARS, Lisa R, ADAMSON, Peter C, INGLE, Ashish M, WRIGHT, John, BROCKMAN, Adam H, PATON, Martin

“…Purpose: A phase 1 study to determine the maximum-tolerated dose, dose-limiting toxicity, pharmacokinetics, and biological effects of bortezomib in children…”
Get full text

Kinetic behavior of the pancreatic lipase-colipase-lipid system by Brockman, H.L

“…Pancreatic lipase is a surface-active protein that binds avidly to interfaces comprised of the substrates and products of lipolysis. However, both lipase…”
Get full text

Evaluation of high-field asymmetric waveform ion mobility spectrometry coupled to nanoelectrospray ionization for bioanalysis in drug discovery by Hatsis, Panos, Brockman, Adam H., Wu, Jing-Tao

“…The potential of high‐field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to nanoelectrospray ionization (nanoESI) as a method to improve…”
Get full text

Probe-Immobilized Affinity Chromatography/Mass Spectrometry by Brockman, Adam H, Orlando, Ron

“…A new technique has been developed that provides affinity separations directly on the surface of a matrix-assisted laser desorption/ionization mass…”
Get full text

A Desalting Approach for MALDI-MS Using On-Probe Hydrophobic Self-Assembled Monolayers by Brockman, Adam H, Dodd, Brian S, Orlando, Ron

“…One of the problems encountered in preparing samples for matrix-assisted laser desorption/ionization (MALDI) analysis is the presence of nonvolatile salts in…”
Get full text

Peripheral Protein Adsorption to Lipid-Water Interfaces: The Free Area Theory by Sugár, I.P., Mizuno, N.K., Brockman, H.L.

“…In fluid monolayers approaching collapse, phospholipids and their complexes with diacylglycerols hinder adsorption to the monolayer of the amphipathic protein,…”
Get full text

On-Probe Solid-Phase Extraction/MALDI-MS Using Ion-Pairing Interactions for the Cleanup of Peptides and Proteins by Warren, Maria Esteban, Brockman, Adam H, Orlando, Ron

“…Samples originating from biological sources often contain a complex mixture of inorganic salts, buffers, chaotropic agents, surfactants/detergents,…”
Get full text

Phosphatidylcholine acyl unsaturation modulates the decrease in interfacial elasticity induced by cholesterol by Smaby, J.M., Momsen, M.M., Brockman, H.L., Brown, R.E.

“…The effect of cholesterol on the interfacial elastic packing interactions of various molecular species of phosphatidylcholines (PCs) has been investigated by…”
Get full text

Cholesterol Decreases the Interfacial Elasticity and Detergent Solubility of Sphingomyelins by Li, Xin-Min, Momsen, Maureen M, Smaby, Janice M, Brockman, Howard L, Brown, Rhoderick E

“…The interfacial interactions of cholesterol with sphingomyelins (SMs) containing various homogeneous acyl chains have been investigated by Langmuir film…”
Get full text

Real-time measurement of solute partitioning to lipid monolayers by Momsen, W.E., Mizuno, N.K., Lowe, M.E., Brockman, H.L.

“…The interaction of a peripheral protein with a lipid–water interface can show a pronounced dependence on the composition and two-dimensional packing density of…”
Get full text

Simple Method Provides Resolution of Albumin, Lipoprotein, Free Fraction, and Chylomicron To Enhance the Utility of Protein Binding Assays by Brockman, Adam H, Oller, Haley R, Moreau, Benoît, Kriksciukaite, Kristina, Bilodeau, Mark T

“…Medicinal chemists have been encouraged in recent years to embrace high speed protein binding assays. These methods employ dialysis membranes in 96-well format…”
Get full text

Speech Outcomes after Tonsillectomy in Patients with Known Velopharyngeal Insufficiency by Paulson, L. M., MacArthur, C. J., Beaulieu, K. B., Brockman, J. H., Milczuk, H. A.

“…Introduction. Controversy exists over whether tonsillectomy will affect speech in patients with known velopharyngeal insufficiency (VPI), particularly in those…”
Get full text

Interfacial Interactions of Ceramide with Dimyristoylphosphatidylcholine: Impact of the N-Acyl Chain by Holopainen, Juha M., Brockman, Howard L., Brown, Rhoderick E., Kinnunen, Paavo K.J.

“…The mixing behavior of dimyristoylphosphatidylcholine (DMPC) with either N-palmitoyl-sphingosine (C16:0-ceramide) or N-nervonoyl-sphingosine (C24:1-ceramide)…”
Get full text

Sphingomyelin Interfacial Behavior: The Impact of Changing Acyl Chain Composition by Li, Xin-Min, Smaby, Janice M., Momsen, Maureen M., Brockman, Howard L., Brown, Rhoderick E.

“…Sphingomyelins (SMs) containing homogeneous acyl chains with 12, 14, 16, 18, 24, or 26 carbons were synthesized and characterized using an automated…”
Get full text

Learning to "think like a geneticist" with the de Serres ad-3 forward-mutation test in Neurospora crassa by Brockman, H E

Get more information

Surface dipole moments of lipids at the argon-water interface. Similarities among glycerol-ester-based lipids by Smaby, J.M., Brockman, H.L.

“…Surface potential-surface pressure-area isotherms at the argon-buffer interface have been determined for 38 lipid species comprising 19 chemical classes. These…”
Get full text

Lateral lipid distribution is a major regulator of lipase activity. Implications for lipid-mediated signal transduction by MUDERHWA, J. M, ROCKMAN, H. L

“…Pancreatic carboxylester lipase catalyzes the exchange of 18O between water and 13,16-cis,cis-doco-sadienoic acid (DA) in monolayers at the argon-buffer…”
Get full text

Specificity of the lipid-binding domain of apoC-II for the substrates and products of lipolysis by Dahim, M, Momsen, W E, Momsen, M M, Brockman, H L

“…Functional similarities between colipase and apolipoprotein C-II (apoC-II) in activating lipases suggest that apoC-II may, like colipase, preferentially…”
Get full text