Search Results - "Brocklehurst, Katy J."

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans by Stone, Virginia M., Dhayal, Shalinee, Brocklehurst, Katy J., Lenaghan, Carol, Sörhede Winzell, Maria, Hammar, Mårten, Xu, Xiufeng, Smith, David M., Morgan, Noel G.

“…Aims/hypothesis The NEFA-responsive G-protein coupled receptor 120 (GPR120) has been implicated in the regulation of inflammation, in the control of incretin…”
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Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation by Scott, James S, Birch, Alan M, Brocklehurst, Katy J, Broo, Anders, Brown, Hayley S, Butlin, Roger J, Clarke, David S, Davidsson, Öjvind, Ertan, Anne, Goldberg, Kristin, Groombridge, Sam D, Hudson, Julian A, Laber, David, Leach, Andrew G, MacFaul, Philip A, McKerrecher, Darren, Pickup, Adrian, Schofield, Paul, Svensson, Per H, Sörme, Pernilla, Teague, Joanne

“…G protein coupled receptor 119 (GPR119) is viewed as an attractive target for the treatment of type 2 diabetes and other elements of the metabolic syndrome…”
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Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators by BROCKLEHURST, Katy J, PAYNE, Victoria A, AGIUS, Loranne, DAVIES, Rick A, CARROLL, Debra, VERTIGAN, Helen L, WIGHTMAN, Heather J, ALSTON, Susan, WADDELL, Ian D, LEIGHTON, Brendan, COGHLAN, Matthew P

“…Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators Katy J. Brocklehurst 1 , Victoria A. Payne 2 , Rick A. Davies 1 ,…”
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The cytoprotective effects of oleoylethanolamide in insulin‐secreting cells do not require activation of GPR119 by Stone, Virginia M, Dhayal, Shalinee, Smith, David M, Lenaghan, Carol, Brocklehurst, Katy J, Morgan, Noel G

“…BACKGROUND AND PURPOSE β‐cells express a range of fatty acid‐responsive G protein‐coupled receptors, including GPR119, which regulates insulin secretion and is…”
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Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists by Scott, James S, Bowker, Suzanne S, Brocklehurst, Katy J, Brown, Hayley S, Clarke, David S, Easter, Alison, Ertan, Anne, Goldberg, Kristin, Hudson, Julian A, Kavanagh, Stefan, Laber, David, Leach, Andrew G, MacFaul, Philip A, Martin, Elizabeth A, McKerrecher, Darren, Schofield, Paul, Svensson, Per H, Teague, Joanne

“…Agonism of GPR119 is viewed as a potential therapeutic approach for the treatment of type II diabetes and other elements of metabolic syndrome. During…”
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Conformational restriction in a series of GPR119 agonists: Differences in pharmacology between mouse and human by Scott, James S., Brocklehurst, Katy J., Brown, Hayley S., Clarke, David S., Coe, Helen, Groombridge, Sam D., Laber, David, MacFaul, Philip A., McKerrecher, Darren, Schofield, Paul

“…A series of conformationally restricted GPR119 agonists were prepared based around a 3,8-diazabicyclo[3.2.1]octane scaffold. Examples were found to have…”
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Discovery, optimisation and in vivo evaluation of novel GPR119 agonists by Brocklehurst, Katy J., Broo, Anders, Butlin, Roger J., Brown, Hayley S., Clarke, David S., Davidsson, Öjvind, Goldberg, Kristin, Groombridge, Sam D., Kelly, Elizabeth E., Leach, Andrew, McKerrecher, Darren, O’Donnell, Charles, Poucher, Simon, Schofield, Paul, Scott, James S., Teague, Joanne, Westgate, Leanne, Wood, Matt J.M.

“…GPR119 is increasingly seen as an attractive target for the treatment of type II diabetes and other elements of the metabolic syndrome. During a programme…”
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Differences in regulatory properties between human and rat glucokinase regulatory protein by Brocklehurst, Katy J, Davies, Rick A, Agius, Loranne

“…The inhibition of glucokinase by rat and Xenopus GKRPs (glucokinase regulatory protein) is well documented. We report a comparison of the effects of human and…”
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Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase by Sullivan, Jane E., Brocklehurst, Katy J., Marley, Anna E., Carey, Frank, Carling, David, Beri, Raj K.

“…In vivo, hormone-sensitive lipase (HSL) is known to be phosphorylated on two sites termed the regulatory and basal sites. However, the intracellular role of…”
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Acute Administration of Fructose, with Glucose, Causes a Significant Decrease in Early Plasma Glucose Levels in Rodents.(Brief Article) by ATKINSON, ANNIE M, LEIGHTON, BRENDAN, BROCKLEHURST, KATY J, WIGHTMAN, HEATHER M, VERTIGAN, HELEN L, HARGREAVES, ROD B, WARNER, PETER, WADDELL, IAN D

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Clenbuterol is not an agonist of Na+ dependent creatine transport by Thorpe, K A, Brocklehurst, K J, Blackburn, S J, Holloway, B R, Waddell, I D

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