Search Results - "Brockhoff, Anne"

Human Psychometric and Taste Receptor Responses to Steviol Glycosides by Hellfritsch, Caroline, Brockhoff, Anne, Stähler, Frauke, Meyerhof, Wolfgang, Hofmann, Thomas

“…Steviol glycosides, the sweet principle of Stevia Rebaudiana (Bertoni) Bertoni, have recently been approved as a food additive in the EU. The herbal…”
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The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors by Meyerhof, Wolfgang, Batram, Claudia, Kuhn, Christina, Brockhoff, Anne, Chudoba, Elke, Bufe, Bernd, Appendino, Giovanni, Behrens, Maik

“…Humans perceive thousands of compounds as bitter. In sharp contrast, only ∼25 taste 2 receptors (TAS2R) bitter taste receptors have been identified, raising…”
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Structural requirements of bitter taste receptor activation by Brockhoff, Anne, Behrens, Maik, Niv, Masha Y., Meyerhof, Wolfgang, Kobilka, Brian K.

“…An important question in taste research is how 25 receptors of the human TAS2R family detect thousands of structurally diverse compounds. An answer to this…”
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Receptor agonism and antagonism of dietary bitter compounds by Brockhoff, Anne, Behrens, Maik, Roudnitzky, Natacha, Appendino, Giovanni, Avonto, Cristina, Meyerhof, Wolfgang

“…Food contains complex blends of structurally diverse bitter compounds that trigger bitterness through activation of one or more of the ∼25 human TAS2 bitter…”
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Comprehensive structure-activity-relationship studies of sensory active compounds in licorice (Glycyrrhiza glabra) by Schmid, Christian, Brockhoff, Anne, Shoshan-Galeczki, Yaron Ben, Kranz, Maximilian, Stark, Timo D., Erkaya, Rukiye, Meyerhof, Wolfgang, Niv, Masha Y., Dawid, Corinna, Hofmann, Thomas

“…•Isolation and synthesis of 28 saponins by a sensomics approach from Glycyrrhiza glabra.•Structural characterization of two unknown saponins in Glycyrrhiza…”
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Sweet-taste-suppressing compounds: current knowledge and perspectives of application by Sigoillot, Maud, Brockhoff, Anne, Meyerhof, Wolfgang, Briand, Loïc

“…Sweet-tasting compounds are recognized by a heterodimeric receptor composed of the taste receptor, type 1, members 2 (T1R2) and 3 (T1R3) located in the mouth…”
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Sensomics Analysis of Taste Compounds in Balsamic Vinegar and Discovery of 5‑Acetoxymethyl-2-furaldehyde as a Novel Sweet Taste Modulator by Hillmann, Hedda, Mattes, Juliane, Brockhoff, Anne, Dunkel, Andreas, Meyerhof, Wolfgang, Hofmann, Thomas

“…Sensory-directed fractionation of traditional balsamic vinegar of Modena (TBV) led to the identification of the sweet-bitter tasting hexose acetates…”
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Broad Tuning of the Human Bitter Taste Receptor hTAS2R46 to Various Sesquiterpene Lactones, Clerodane and Labdane Diterpenoids, Strychnine, and Denatonium by Brockhoff, Anne, Behrens, Maik, Massarotti, Alberto, Appendino, Giovanni, Meyerhof, Wolfgang

“…Sesquiterpene lactones are a major class of natural bitter compounds occurring in vegetables and culinary herbs as well as in aromatic and medicinal plants,…”
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Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist by Slack, Jay P., Brockhoff, Anne, Batram, Claudia, Menzel, Susann, Sonnabend, Caroline, Born, Stephan, Galindo, Maria Mercedes, Kohl, Susann, Thalmann, Sophie, Ostopovici-Halip, Liliana, Simons, Christopher T., Ungureanu, Ioana, Duineveld, Kees, Bologa, Cristian G., Behrens, Maik, Furrer, Stefan, Oprea, Tudor I., Meyerhof, Wolfgang

“…Human bitter taste is mediated by the hTAS2R family of G protein-coupled receptors [1–4]. The discovery of the hTAS2Rs enables the potential to develop…”
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The Human Bitter Taste Receptor hTAS2R50 Is Activated by the Two Natural Bitter Terpenoids Andrographolide and Amarogentin by Behrens, Maik, Brockhoff, Anne, Batram, Claudia, Kuhn, Christina, Appendino, Giovanni, Meyerhof, Wolfgang

“…Bitterness perception in mammals is mediated through activation of dedicated bitter taste receptors located in the oral cavity. Genomic analyses revealed the…”
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Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor by Biarnés, Xevi, Marchiori, Alessandro, Giorgetti, Alejandro, Lanzara, Carmela, Gasparini, Paolo, Carloni, Paolo, Born, Stephan, Brockhoff, Anne, Behrens, Maik, Meyerhof, Wolfgang

“…Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs). Structural information on these…”
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The human taste receptor hTAS2R14 responds to a variety of different bitter compounds by Behrens, Maik, Brockhoff, Anne, Kuhn, Christina, Bufe, Bernd, Winnig, Marcel, Meyerhof, Wolfgang

“…The recent advances in the functional expression of TAS2Rs in heterologous systems resulted in the identification of bitter tastants that specifically activate…”
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Functional characterization of an allatotropin receptor expressed in the corpora allata of mosquitoes by Nouzova, Marcela, Brockhoff, Anne, Mayoral, Jaime G., Goodwin, Marianne, Meyerhof, Wolfgang, Noriega, Fernando G.

“…[Display omitted] ► We characterized an allatotropin receptor expressed in the mosquito Aedes aegypti. ► The receptor is stimulated by mosquito allatotropin in…”
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The Odorant (R)‑Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46 by Suess, Barbara, Brockhoff, Anne, Meyerhof, Wolfgang, Hofmann, Thomas

“…Sensory studies showed the volatile fraction of lemon grass and its main constituent, the odor-active citronellal, to significantly decrease the perceived…”
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Evidence for a Transient Additional Ligand Binding Site in the TAS2R46 Bitter Taste Receptor by Sandal, Massimo, Behrens, Maik, Brockhoff, Anne, Musiani, Francesco, Giorgetti, Alejandro, Carloni, Paolo, Meyerhof, Wolfgang

“…Most human G protein coupled receptors (GPCRs) are activated by small molecules binding to their 7-transmembrane (7-TM) helix bundle. They belong to basally…”
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Sensory-Guided Multidimensional Exploration of Antisweet Principles from Gymnema sylvestre (Retz) Schult by Pickrahn, Stephen, Dawid, Corinna, Babinger, Timo, Schmid, Christian, Brockhoff, Anne, Meyerhof, Wolfgang, Hofmann, Thomas

“…We report on activity-guided investigation of the key antisweet principles of Gymnema sylvestre. Orosensory-guided fractionation by means of solid phase…”
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Human Taste and Umami Receptor Responses to Chemosensorica Generated by Maillard-type N 2‑Alkyl- and N 2‑Arylthiomethylation of Guanosine 5′-Monophosphates by Suess, Barbara, Brockhoff, Anne, Degenhardt, Andreas, Billmayer, Sylvia, Meyerhof, Wolfgang, Hofmann, Thomas

“…Structural modification of the exocyclic amino function of guanosine 5′-monophosphate (5′-GMP) by Maillard-type reactions with reducing carbohydrates was…”
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The Crystal Structure of Gurmarin, a Sweet Taste-Suppressing Protein: Identification of the Amino Acid Residues Essential for Inhibition by Sigoillot, Maud, Brockhoff, Anne, Neiers, Fabrice, Poirier, Nicolas, Belloir, Christine, Legrand, Pierre, Charron, Christophe, Roblin, Pierre, Meyerhof, Wolfgang, Briand, Loïc

“…Abstract Gurmarin is a highly specific sweet taste-suppressing protein in rodents that is isolated from the Indian plant Gymnema sylvestre. Gurmarin consists…”
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Optimization of the production of gurmarin, a sweet-taste-suppressing protein, secreted by the methylotrophic yeast Pichia pastoris by Sigoillot, Maud, Brockhoff, Anne, Lescop, Ewen, Poirier, Nicolas, Meyerhof, Wolfgang, Briand, Loïc

“…Gurmarin, a 35-residue polypeptide, is known to selectively inhibit responses to sweet substances in rodents without affecting responses to other basic taste…”
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Molecular biology of mammalian bitter taste receptors. A review by Meyerhof, Wolfgang, Born, Stephan, Brockhoff, Anne, Behrens, Maik

“…Bitter taste prevents mammals from ingesting food potentially contaminated with bitter-tasting toxins, which are frequent and structurally diverse. It is…”
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