Search Results - "Brockenbrough, J Scott"

Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase by DuFort, Christopher C., DelGiorno, Kathleen E., Carlson, Markus A., Osgood, Ryan J., Zhao, Chunmei, Huang, Zhongdong, Thompson, Curtis B., Connor, Robert J., Thanos, Christopher D., Scott Brockenbrough, J., Provenzano, Paolo P., Frost, Gregory I., Michael Shepard, H., Hingorani, Sunil R.

“…Elevated interstitial fluid pressure can present a substantial barrier to drug delivery in solid tumors. This is particularly true of pancreatic ductal…”
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T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma by Stromnes, Ingunn M., Schmitt, Thomas M., Hulbert, Ayaka, Brockenbrough, J. Scott, Nguyen, Hieu N., Cuevas, Carlos, Dotson, Ashley M., Tan, Xiaoxia, Hotes, Jennifer L., Greenberg, Philip D., Hingorani, Sunil R.

“…Pancreatic ductal adenocarcinomas (PDAs) erect physical barriers to chemotherapy and induce multiple mechanisms of immune suppression, creating a sanctuary for…”
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Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity by Stromnes, Ingunn M, Brockenbrough, J Scott, Izeradjene, Kamel, Carlson, Markus A, Cuevas, Carlos, Simmons, Randi M, Greenberg, Philip D, Hingorani, Sunil R

“…Pancreatic ductal adenocarcinoma (PDA) is characterised by a robust desmoplasia, including the notable accumulation of immunosuppressive cells that shield…”
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Thymidine Kinase 1 and Thymidine Phosphorylase Expression in Non-Small-cell Lung Carcinoma in Relation to Angiogenesis and Proliferation by Brockenbrough, J. Scott, Morihara, Janice K, Hawes, Stephen E, Stern, Joshua E, Rasey, Janet S, Wiens, Linda W, Feng, Qinghua, Vesselle, Hubert

“…The thymidine salvage pathway enzymes thymidine kinase 1 (TK1) and thymidine phosphorylase (TP) compete for thymidine as a substrate and catalyze opposing…”
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Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma by Stromnes, Ingunn M, Burrack, Adam L, Hulbert, Ayaka, Bonson, Patrick, Black, Cheryl, Brockenbrough, J Scott, Raynor, Jackson F, Spartz, Ellen J, Pierce, Robert H, Greenberg, Philip D, Hingorani, Sunil R

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapies, including immune-checkpoint blockade. We investigated two distinct…”
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Issues in Biomedical Research Data Management and Analysis: Needs and Barriers by Anderson, Nicholas R., Lee, E. Sally, Brockenbrough, J. Scott, Minie, Mark E., Fuller, Sherrilynne, Brinkley, James, Tarczy-Hornoch, Peter

“…A. Identify the current state of data management needs of academic biomedical researchers. B. Explore their anticipated data management and analysis needs. C…”
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Paternal Monoallelic Expression of the Paired Immunoglobulin-Like Receptors PIR-A and PIR-B by Chen, Ching-Cheng, Hurez, Vincent, Brockenbrough, J. Scott, Kubagawa, Hiromi, Cooper, Max D.

“…A diverse pattern of polymorphism is defined for the paired Ig-like receptors (PIRs) that serve as activating (PIR-A) and inhibitory (PIR-B) receptors on B…”
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Synthesis and in Vitro Evaluation of 5-Fluoro-6-[(2-Iminopyrrolidin-1-YL)Methyl]Uracil, TPI(F): An Inhibitor of Human Thymidine Phosphorylase (TP) by Grierson, John R., Brockenbrough, J. Scott, Rasey, Janet S., Wiens, Linda, Vesselle, Hubert

“…An investigation was conducted to determine if the 5-fluoro analog of TPI (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]uracil), a potent inhibitor of human…”
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Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast by Wu, P. (University of Florida, Gainesville), Brockenbrough, J.S, Metcalfe, A.C, Chen, S, Aris, J.P

“…We have identified a novel nucleolar protein, Nop5p, that is essential for growth in Saccharomyces cerevisiae . Monoclonal antibodies B47 and 37C12 recognize…”
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Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast by Hong, Bo, Brockenbrough, J. Scott, Wu, Pei, Aris, John P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Evaluation of 5′-deoxy-5′-[F-18]fluorothymidine as a tracer of intracellular thymidine phosphorylase activity by Grierson, John R, Brockenbrough, J. Scott, Rasey, Janet S, Wiens, Linda W, Schwartz, Jeffery L, Jordan, Robert, Vesselle, Hubert

“…Abstract Two human cell lines (A549 and U937) with cytosolic thymidine phosphorylase (TP) activity were used to evaluate the potential of…”
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A simple quantitative assay for the activity of thymidine kinase 1 in solid tumors by Brockenbrough, J. Scott, Rasey, Janet S, Grierson, John R, Wiens, Linda W, Vesselle, Hubert

“…Abstract Introduction The activity of the pyrimidine salvage pathway enzyme thymidine kinase 1 (TK1) is tightly cell cycle regulated and has been investigated…”
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Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae by Hong, B, Wu, K, Brockenbrough, J S, Wu, P, Aris, J P

“…Using molecular genetic techniques, we have generated and characterized six temperature sensitive (ts) alleles of nop2. All failed to support growth at 37…”
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Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker by De Beus, E. (The Mount Sinai School of Medicine, New York, NY.), Brockenbrough, J.S, Hong, B, Aris, J.P

“…We have isolated a gene (NOP2) encoding a nucleolar protein during a search for previously unidentified nuclear proteins in the yeast Saccharomyces cerevisiae…”
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Discordance of exocrine and endocrine growth after 90 % pancreatectomy in rats by BROCKENBROUGH, J. S, WEIR, G. C, BONNER-WEIR, S

“…As we have previously shown, by 8 wk after 90% pancreatectomy (PX) in the rat, there is considerable regeneration of both exocrine and endocrine pancreas. In…”
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Abstract A80: Targeted depletion of extracellular matrix components in PDA eases barriers to treatment by Carlson, Markus A., Dufort, Christopher C., DelGiorno, Kathleen E., Brockenbrough, J. Scott, Dotson, Ashley M., Hingorani, Sunil R.

“…Abstract The complex microenvironment found in pancreas cancer is characterized by an extremely dense extracellular matrix (ECM), excessive desmoplasia,…”
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Homocitrate Synthase Is Located in the Nucleus in the YeastSaccharomyces cerevisiae by Chen, Shaoping, Brockenbrough, J. Scott, Dove, Joanne E., Aris, John P.

“…We have generated monoclonal antibodies against nuclear proteins from the yeast Saccharomyces cerevisiae . The monoclonal antibodies react with proteins of 47…”
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Abstract A92: Murine clinical trials program by Brockenbrough, J. Scott, Feng, Libing, Stromnes, Ingunn M., DelGiorno, Kathleen E., Whittle, Martin C., Cuevas, Carlos, Dotson, Ashley M., Ryan, Joseph S., Thorsen, Shelley M., Hingorani, Sunil R.

“…Abstract Enormous advances in the biomedical sciences have raised tenable hope of a new era of personalized medicine. Significant hurdles to realizing this…”
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Tumor 3'-Deoxy-3'-^sup 18^F-Fluorothymidine (^sup 18^F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of ^sup 18^F-FLT PET Studies in Lung Tumors by Brockenbrough, J Scott, Souquet, Timothee, Morihara, Janice K, Stern, Joshua E, Hawes, Stephen E, Rasey, Janet S, Leblond, Antoine, Wiens, Linda W, Feng, Qinghua, Grierson, John, Vesselle, Hubert

“…We report the first, to our knowledge, findings describing the relationships between both static and dynamic analysis parameters of 3'-deoxy-3'-^sup…”
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Tumor 3′-Deoxy-3′- 18 F-Fluorothymidine ( 18 F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of 18 F-FLT PET Studies in Lung Tumors by Brockenbrough, J. Scott, Souquet, Timothee, Morihara, Janice K., Stern, Joshua E., Hawes, Stephen E., Rasey, Janet S., Leblond, Antoine, Wiens, Linda W., Feng, Qinghua, Grierson, John, Vesselle, Hubert

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