Search Results - "Brock, Thomas"

A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 3: Inflammatory response following acute inhalation exposure correlates with lower tier data by Viegas, Vanessa, Burzlaff, Arne, Brock, Thomas O., Danzeisen, Ruth

“…In vitro studies have shown that cobalt substances predominantly induce pre-inflammatory biomarkers, resulting in a grouping of substances either predicted to…”
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Catastrophe or Catalyst? Reflections on COVID’s Impact on Community Colleges by Brock, Thomas, Diwa, Cameron

“…The COVID-19 pandemic led to a steep decline in enrollments at community colleges, especially among Black, Hispanic, and Indigenous populations, males, and…”
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Safely prolonging single breath-holds to >5 min in patients with cancer; feasibility and applications for radiotherapy by Parkes, Michael J, Green, Stuart, Stevens, Andrea M, Parveen, Sophia, Stephens, Rebecca, Clutton-Brock, Thomas H

“…Multiple, short and deep inspiratory breath-holds with air of approximately 20 s are now used in radiotherapy to reduce the influence of ventilatory motion and…”
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Leukotriene B4 Is a Physiologically Relevant Endogenous Peroxisome Proliferator-activated Receptor-α Agonist by Narala, Venkata R., Adapala, Ravi K., Suresh, Madathilparambil V., Brock, Thomas G., Peters-Golden, Marc, Reddy, Raju C.

“…Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors that play central roles in metabolism and inflammation. Although a…”
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Safely prolonging single breath-holds to >5min in patients with cancer; feasibility and applications for radiotherapy by Parkes, Michael J, Green, Stuart, Stevens, Andrea M, Parveen, Sophia, Stephens, Rebecca, Clutton-Brock, Thomas H

“…Objective: Multiple, short and deep inspiratory breath-holds with air of approximately 20s are now used in radiotherapy to reduce the influence of ventilatory…”
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Sarcopenic Obesity Is a Risk Factor for Worse Oncological Long-Term Outcome in Locally Advanced Rectal Cancer Patients: A Retrospective Single-Center Cohort Study by Tschann, Peter, Weigl, Markus P, Clemens, Patrick, Szeverinski, Philipp, Attenberger, Christian, Kowatsch, Matthias, Jäger, Tarkan, Emmanuel, Klaus, Brock, Thomas, Königsrainer, Ingmar

“…Malnutrition and skeletal muscle waste (sarcopenia) are known as predictive factors for a poor postoperative outcome. Paradoxically, obesity seems to be…”
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Phosphorylation of Serine 271 on 5-Lipoxygenase and Its Role in Nuclear Export by Flamand, Nicolas, Luo, Ming, Peters-Golden, Marc, Brock, Thomas G.

“…The enzyme 5-lipoxygenase (5-LO) initiates the biosynthesis of leukotrienes, inflammatory mediators involved in immune diseases and defense. The subcellular…”
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The Influence of VE-Cadherin on Adhesion and Incorporation of Breast Cancer Cells into Vascular Endothelium by Brock, Thomas, Boudriot, Elisabeth, Klawitter, Anke, Großer, Marianne, Nguyen, Trang T. P., Giebe, Sindy, Klapproth, Erik, Temme, Achim, El-Armouche, Ali, Breier, Georg

“…During metastasis, cancer cells that originate from the primary tumor circulate in the bloodstream, extravasate, and form micrometastases at distant locations…”
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Reducing the within-patient variability of breathing for radiotherapy delivery in conscious, unsedated cancer patients using a mechanical ventilator by Parkes, Michael J, Green, Stuart, Stevens, Andrea M, Parveen, Sophia, Stephens, Rebecca, Clutton-Brock, Thomas H

“…Variability in the breathing pattern of patients with cancer during radiotherapy requires mitigation, including enlargement of the planned treatment field,…”
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Molecular Dynamics Simulation of Poly(ethylene terephthalate) Oligomers by Wang, Qifei, Keffer, David J, Petrovan, Simioan, Thomas, J. Brock

“…Molecular dynamics simulations of poly(ethylene terephthalate) (PET) oligomers are performed in the isobaric−isothermal (NpT) ensemble at a state point typical…”
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Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity by Luo, Ming, Jones, Sandra M, Peters-Golden, Marc, Brock, Thomas G

“…The enzyme 5-lipoxygenase (5-LO) initiates the synthesis of leukotrienes from arachidonic acid. In resting cells, 5-LO can accumulate in either the cytoplasm…”
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Hypocapnia Alone Fails to Provoke Important Electrocardiogram Changes in Coronary Artery Diseased Patients by Parkes, Michael J, Sheppard, James P, Barker, Thomas, Ranasinghe, Aaron M, Senanayake, Eshan, Clutton-Brock, Thomas H, Frenneaux, Michael P

“…There is still an urgent clinical need to develop non-invasive diagnostic tests for early ischemic heart disease because, once angina occurs, it is too late…”
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Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase by Brock, Thomas G.

“…Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5‐lipoxygenase…”
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Molecular Aspects of Mucoadhesive Carrier Development for Drug Delivery and Improved Absorption by Peppas, Nicholas A., Thomas, J. Brock, McGinty, James

“…Although the oral route remains the most favored route of drug administration, major scientific obstacles prevent the effective and efficient delivery of…”
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Positive effects of lumbar puncture simulation training for medical students in clinical practice by Gaubert, Sinead, Blet, Alice, Dib, Fadia, Ceccaldi, Pierre-François, Brock, Thomas, Calixte, Maude, De Macédo, Léa, Dujardin, Tiphaine, Jean-Louis, Ludivine, Leghima, Dhihia, Mouyal, Samuel, Tordjman, Dan David, Plaisance, Patrick, Roos, Caroline, Remini, Sid-Ahmed, Roux, Damien, Paquet, Claire

“…Lumbar puncture (LP) is an invasive medical procedure that can be done by any doctor. Several simulation-based trainings have been built however the…”
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Arachidonic Acid Binds 14-3-3ζ, Releases 14-3-3ζ from Phosphorylated BAD and Induces Aggregation of 14-3-3ζ by Brock, Thomas G.

“…Polyunsaturated fatty acids, like arachidonic acid, can bind proteins and affect their function. The 14-3-3 proteins bind phosphorylated sites on a diverse…”
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Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia by Mancuso, Peter, Peters-Golden, Marc, Goel, Deepti, Goldberg, Jared, Brock, Thomas G, Greenwald-Yarnell, Megan, Myers, Jr, Martin G

“…The adipocyte-derived hormone leptin regulates energy homeostasis and the innate immune response. We previously reported that leptin plays a protective role in…”
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Release of Microplastics from Reusable Kitchen Plasticware and Generation of Thermal Potential Toxic Degradation Products in the Oven by Jander, Juri, Hummel, Darius, Stürmer, Sophie, Monteleone, Adrian, Neumaier, Tizian, Broghammer, Felix, Lewin-Kretzschmar, Uta, Brock, Thomas, Knoll, Martin, Fath, Andreas Siegbert

“…Plastics are one of the most important technical materials at present, yet they are associated with a whole series of environmental problems such as micro-and…”
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Inter-laboratory validation of bioaccessibility testing for metals by Henderson, Rayetta G., Verougstraete, Violaine, Anderson, Kim, Arbildua, José J., Brock, Thomas O., Brouwers, Tony, Cappellini, Danielle, Delbeke, Katrien, Herting, Gunilla, Hixon, Greg, Odnevall Wallinder, Inger, Rodriguez, Patricio H., Van Assche, Frank, Wilrich, Peter, Oller, Adriana R.

“…•Intra- and inter-laboratory variability of bioelution tests were evaluated.•5 laboratories tested 6 metal-containing materials in 4 synthetic fluids.•Absolute…”
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Misoprostol Impairs Female Reproductive Tract Innate Immunity against Clostridium sordellii by Aronoff, David M, Hao, Yibai, Chung, Jooho, Coleman, Nicole, Lewis, Casey, Peres, Camila M, Serezani, Carlos H, Chen, Gwo-Hsiao, Flamand, Nicolas, Brock, Thomas G, Peters-Golden, Marc

“…Fatal cases of acute shock complicating Clostridium sordellii endometritis following medical abortion with mifepristone (also known as RU-486) used with…”
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