Search Results - "Brock, Robert W."

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes by Reid, Angela B, Kurten, Richard C, McCullough, Sandra S, Brock, Robert W, Hinson, Jack A

“…Freshly isolated mouse hepatocytes were used to determine the role of mitochondrial permeability transition (MPT) in acetaminophen (APAP) toxicity. Incubation…”
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Hypercholesterolemia and microvascular dysfunction: interventional strategies by Stapleton, Phoebe A, Goodwill, Adam G, James, Milinda E, Brock, Robert W, Frisbee, Jefferson C

“…Hypercholesterolemia is defined as excessively high plasma cholesterol levels, and is a strong risk factor for many negative cardiovascular events. Total…”
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Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice by Wu, Liping, Tiwari, Manish M, Messer, Kurt J, Holthoff, Joseph H, Gokden, Neriman, Brock, Robert W, Mayeux, Philip R

“…The mortality rate for septic patients with acute renal failure is extremely high. Since sepsis is often caused by lipopolysaccharide (LPS), a model of LPS…”
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Disruption of renal peritubular blood flow in lipopolysaccharide-induced renal failure: role of nitric oxide and caspases by Tiwari, Manish M, Brock, Robert W, Megyesi, Judit K, Kaushal, Gur P, Mayeux, Philip R

“…Acute renal failure (ARF) is a frequent and serious complication of endotoxemia caused by lipopolysaccharide (LPS) and contributes significantly to mortality…”
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Alteration of renal respiratory Complex-III during experimental type-1 diabetes by Munusamy, Shankar, Saba, Hamida, Mitchell, Tanecia, Megyesi, Judit K, Brock, Robert W, Macmillan-Crow, Lee Ann

“…Diabetes has become the single most common cause for end-stage renal disease in the United States. It has been established that mitochondrial damage occurs…”
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Obesity, Insulin Resistance and Hepatic Perfusion by Brock, Robert W., Dorman, Robert B.

“…Insulin resistance brings together the collection of hyperglycemia, hyperinsulinemia, and dyslipidemia associated with pathologies such as obesity and type 2…”
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Inhibition of haem oxygenase activity increases leukocyte accumulation in the liver following limb ischaemia-reperfusion in mice by Wunder, Christian, Brock, Robert W., McCarter, Sarah D., Bihari, Aurelia, Harris, Kenneth, Eichelbrönner, Otto, Potter, Richard F.

“…The role of haem oxygenase (HO) in the hepatic accumulation of leukocytes in mice during the initiation of remote organ injury following normotensive limb…”
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The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence? by Halvorson, Brayden D, Menon, Nithin J, Goldman, Daniel, Frisbee, Stephanie J, Goodwill, Adam G, Butcher, Joshua T, Stapleton, Phoebe A, Brooks, Steven D, d'Audiffret, Alexandre C, Wiseman, Robert W, Lombard, Julian H, Brock, Robert W, Olfert, I Mark, Chantler, Paul D, Frisbee, Jefferson C

“…The study of peripheral vasculopathy with chronic metabolic disease is challenged by divergent contributions from spatial (the level of resolution or specific…”
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Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury by Burkard, Natalie, Baar, Wolfgang, Flemming, Sven, Schlegel, Nicolas, Wollborn, Jakob, Schneider, Reinhard, Brock, Robert W, Wunder, Christian, Schick, Martin Alexander

“…AKI in septic patients is associated with increased mortality and poor outcome despite major efforts to refine the understanding of its pathophysiology. Here,…”
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Altered post‐capillary and collecting venular reactivity in skeletal muscle with metabolic syndrome by Lemaster, Kent A., Farid, Zahra, Brock, Robert W., Shrader, Carl D., Goldman, Daniel, Jackson, Dwayne N., Frisbee, Jefferson C.

“…Key points With the development of the metabolic syndrome, both post‐capillary and collecting venular dilator reactivity within the skeletal muscle of obese…”
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Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation by Frisbee, Jefferson C, Butcher, Joshua T, Frisbee, Stephanie J, Olfert, I Mark, Chantler, Paul D, Tabone, Lawrence E, d'Audiffret, Alexandre C, Shrader, Carl D, Goodwill, Adam G, Stapleton, Phoebe A, Brooks, Steven D, Brock, Robert W, Lombard, Julian H

“…To determine the impact of progressive elevations in peripheral vascular disease (PVD) risk on microvascular function, we utilized eight rat models spanning…”
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Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats by Frisbee, Jefferson C, Goodwill, Adam G, Frisbee, Stephanie J, Butcher, Joshua T, Brock, Robert W, Olfert, I Mark, DeVallance, Evan R, Chantler, Paul D

“…Evolution of metabolic syndrome is associated with a progressive reduction in skeletal muscle microvessel density, known as rarefaction. Although contributing…”
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Carbon Monoxide has Antioxidative Properties in the Liver Involving p38 MAP Kinase Pathway in a Murine Model of Systemic Inflammation by BRUGGER, JÜRGEN, SCHICK, MARTIN A., BROCK, ROBERT W., BAUMANN, ANJA, MUELLENBACH, RALF M., ROEWER, NORBERT, WUNDER, CHRISTIAN

“…Please cite this paper as: Brugger, Schick, Brock, Baumann, Muellenbach, Roewer and Wunder (2010). Carbon Monoxide has Antioxidative Properties in the Liver…”
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Integration of skeletal muscle resistance arteriolar reactivity for perfusion responses in the metabolic syndrome by Frisbee, Jefferson C, Hollander, John M, Brock, Robert W, Yu, Han-Gang, Boegehold, Matthew A

“…Previous study suggests that with evolution of the metabolic syndrome, patterns of arteriolar reactivity are profoundly altered and may constrain functional…”
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Pulmonary particulate matter and systemic microvascular dysfunction by Nurkiewicz, Timothy R, Porter, Dale W, Hubbs, Ann F, Stone, Samuel, Moseley, Amy M, Cumpston, Jared L, Goodwill, Adam G, Frisbee, Stephanie J, Perrotta, Peter L, Brock, Robert W, Frisbee, Jefferson C, Boegehold, Matthew A, Frazer, David G, Chen, Bean T, Castranova, Vincent

“…Pulmonary particulate matter (PM) exposure has been epidemiologically associated with an increased risk of cardiovascular morbidity and mortality, but the…”
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Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model by Schick, Martin A, Baar, Wolfgang, Flemming, Sven, Schlegel, Nicolas, Wollborn, Jakob, Held, Christopher, Schneider, Reinhard, Brock, Robert W, Roewer, Norbert, Wunder, Christian

“…Background Up to 50% of septic patients develop acute kidney injury (AKI). The pathomechanism of septic AKI is poorly understood. Therefore, we established an…”
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Liver dysfunction after lung recruitment manoeuvres during pressure-controlled ventilation in experimental acute respiratory distress by Kredel, Markus, Muellenbach, Ralf M, Brock, Robert W, Wilckens, Hans-Hinrich, Brederlau, Joerg, Roewer, Norbert, Wunder, Christian

“…Consequences of lung recruitment with prolonged high positive end-expiratory pressure (PEEP) ventilation for liver function are unclear. We therefore…”
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NAD(P)H oxidase contributes to the progression of remote hepatic parenchymal injury and endothelial dysfunction, but not microvascular perfusion deficits by Dorman, Robert B, Wunder, Christian, Saba, Hamida, Shoemaker, Jennifer L, MacMillan-Crow, Lee Ann, Brock, Robert W

“…Oxidative stress occurs in remote liver injury, but the origin of the oxidant generation has yet to be thoroughly delineated. Some reports suggest that the…”
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Carbon monoxide, but not endothelin-1, plays a major role for the hepatic microcirculation in a murine model of early systemic inflammation by Wunder, Christian, Brock, Robert W, Frantz, Stefan, Göttsch, Winfried, Morawietz, Henning, Roewer, Norbert, Eichelbrönner, Otto

“…OBJECTIVE:Endothelin-1 and carbon monoxide play a major role in the regulation of liver microcirculation in numerous disease states. During sepsis and…”
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C-Peptide Reduces Mitochondrial Superoxide Generation by Restoring Complex I Activity in High Glucose-Exposed Renal Microvascular Endothelial Cells by Kothur, Anand, Vejandla, Himani, Brock, Robert W., Hollander, John M.

“…Hyperglycemia-mediated microvascular damage has been proposed to originate from excessive generation of mitochondrial superoxide in endothelial cells and is…”
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