Search Results - "Broce, Sean"

Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains by Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Hancock, Sandy, Cecere, Thomas, Nguyen, Mai, Arastu-Kapur, Shirin, Broce, Sean, Raha, Debasish, Lynch, Casey C, Holsinger, Leslie J, Dominy, Stephen S, Ermini, Florian

“…Porphyromonas gingivalis (P. gingivalis) and its gingipain virulence factors have been identified as pathogenic effectors in Alzheimer's disease (AD). In a…”
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COR388 for the Treatment of Alzheimer’s Disease (4098) by Detke, Michael, Lynch, Casey, Holsinger, Leslie, Kapur, Shirin, Hennings, Dave, Raha, Debasish, Broce, Sean, Nguyen, Mai, Ermini, Florian, Haditsch, Ursula, Ryder, Mark, Goodman, Ira, Thein, Stephen, Dominy, Stephen

“…Abstract only…”
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COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients: Human/Human trials: Other by Raha, Debasish, Broce, Sean, Haditsch, Ursula, Rodriguez, Leo, Ermini, Florian, Detke, Mike, Kapur, Shirin, Hennings, Dave, Roth, Theresa, Nguyen, Mai, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve

“…Abstract Background We identified the bacterial pathogen, Porphyromonas gingivalis (Pg), and its protease virulence factors, gingipains, in the brain of…”
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COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients by Raha, Debasish, Broce, Sean, Haditsch, Ursula, Rodriguez, Leo, Ermini, Florian, Detke, Mike, Kapur, Shirin, Hennings, Dave, Roth, Theresa, Nguyen, Mai, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve

“…Background We identified the bacterial pathogen, Porphyromonas gingivalis (Pg), and its protease virulence factors, gingipains, in the brain of patients with…”
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Increased levels of phospho‐tau217 in neuron cultures and CVN mice infected with Porphyromonas gingivalis by Ermini, Florian, Haditsch, Ursula, Rodriguez, Leo, Martinez‐Horta, Aurora, Broce, Sean, Raha, Debasish, Nguyen, Mai, Kapur, Shirin, Lynch, Casey C, Holsinger, Leslie J, Dominy, Stephen S

“…Background The oral pathogen Porphyromonas gingivalis has been identified as a causative agent of Alzheimer’s disease (AD) pathology and neurodegeneration…”
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Targeting porphyromonas gingivalis to treat Alzheimer’s disease and comorbid cardiovascular disease: Developing topics by Ermini, Florian, Rojas, Paola, Dean, Afsah, Stephens, Danielle, Patel, Michele, Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Broce, Sean, Raha, Debasish, Nguyen, Mai, Kapur, Shirin, Lynch, Casey C, Dominy, Stephen S, Holsinger, Leslie J, Hasturk, Hatice

“…Abstract Background We recently demonstrated the presence of the bacterial pathogen, Porphyromonas gingivalis ( Pg ), and its protease virulence factors, known…”
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Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss by Ermini, Florian, Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Broce, Sean, Raha, Debasish, Nguyen, Mai, Hancock, Sandy, Cecere, Thomas, Detke, Mike, Kapur, Shirin, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve

“…Background Porphyromonas gingivalis and its proteolytic virulence factors lysine‐gingipain (Kgp) and arginine‐gingipain (Rgp) are emerging as major etiologic…”
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Targeting porphyromonas gingivalis to treat Alzheimer’s disease and comorbid cardiovascular disease by Ermini, Florian, Rojas, Paola, Dean, Afsah, Stephens, Danielle, Patel, Michele, Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Broce, Sean, Raha, Debasish, Nguyen, Mai, Kapur, Shirin, Lynch, Casey C, Dominy, Stephen S, Holsinger, Leslie J, Hasturk, Hatice

“…Background We recently demonstrated the presence of the bacterial pathogen, Porphyromonas gingivalis (Pg), and its protease virulence factors, known as…”
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Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss: Molecular and cell biology/synaptic disruption by Ermini, Florian, Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Broce, Sean, Raha, Debasish, Nguyen, Mai, Hancock, Sandy, Cecere, Thomas, Detke, Mike, Kapur, Shirin, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve

“…Abstract Background Porphyromonas gingivalis and its proteolytic virulence factors lysine‐gingipain (Kgp) and arginine‐gingipain (Rgp) are emerging as major…”
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A pan-respiratory antiviral chemotype targeting a transient host multi-protein complex by Michon, Maya, Müller-Schiffmann, Andreas, Lingappa, Anuradha F, Yu, Shao Feng, Du, Li, Deiter, Fred, Broce, Sean, Mallesh, Suguna, Crabtree, Jackelyn, Lingappa, Usha F, Macieik, Amanda, Müller, Lisa, Ostermann, Philipp Niklas, Andrée, Marcel, Adams, Ortwin, Schaal, Heiner, Hogan, Robert J, Tripp, Ralph A, Appaiah, Umesh, Anand, Sanjeev K, Campi, Thomas W, Ford, Michael J, Reed, Jonathan C, Lin, Jim, Akintunde, Olayemi, Copeland, Kiel, Nichols, Christine, Petrouski, Emma, Moreira, Ana R, Jiang, I-Ting, DeYarman, Nicholas, Brown, Ian, Lau, Sharon, Segal, Ilana, Goldsmith, Danielle, Hong, Shi, Asundi, Vinod, Briggs, Erica M, Phyo, Ngwe Sin, Froehlich, Markus, Onisko, Bruce, Matlack, Kent, Dey, Debendranath, Lingappa, Jaisri R, Prasad, Dharma M, Kitaygorodskyy, Anatoliy, Solas, Dennis, Boushey, Homer, Greenland, John, Pillai, Satish, Lo, Michael K, Montgomery, Joel M, Spiropoulou, Christina F, Korth, Carsten, Selvarajah, Suganya, Paulvannan, Kumar, Lingappa, Vishwanath R

“…We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen…”
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Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals by Broce, Sean, Hensley, Lisa, Sato, Tomoharu, Lehrer-Graiwer, Joshua, Essrich, Christian, Edwards, Katie J, Pajda, Jacqueline, Davis, Christopher J, Bhadresh, Rami, Hurt, Clarence R, Freeman, Beverly, Lingappa, Vishwanath R, Kelleher, Colm A, Karpuj, Marcela V

“…Viral capsid assembly involves the oligomerization of the capsid nucleoprotein (NP), which is an essential step in viral replication and may represent a…”
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Protein–Protein Interactions Occurring During HIV Capsid Assembly in a Cell-free Protein Synthesizing System by Copeland, Kiel, Hansen, William, Asundi, Vinod, Hong, Shi, Chamberlin, James, Dey, Debendranath, Broce, Sean, Himmel, Harold, Decloutte, Caleb, Ram, Salvin, Steffen, Imke, Pöhlmann, Stefan, Lingappa, Jaisri R., Hurt, Clarence R., Lingappa, Vishwanath R.

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Small Molecule Therapeutics of Viruses of Families Bunyaviridae and Arenaviridae by Karpuj, Marcela, Smith, Darci, Kelley-Clarke, Brenna, Stossel, Andrea, Honko, Anna, Broce, Sean, Van Loan, Nessie, Harrell, Emma, Kelleher, Colm, Lingappa, Jaisri R., Hansen, William, Hurt, Clarence R., Hensley, Lisa, Lingappa, Vishwanath R.

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