Search Results - "Brocchini, Steve"

Site-selective protein conjugation at histidine by Peciak, Karolina, Laurine, Emmanuelle, Tommasi, Rita, Choi, Ji-Won, Brocchini, Steve

“…Site-selective conjugation generally requires both (i) molecular engineering of the protein of interest to introduce a conjugation site at a defined location…”
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PEGylation and its impact on the design of new protein-based medicines by Ginn, Claire, Khalili, Hanieh, Lever, Rebecca, Brocchini, Steve

“…PEGylation is the covalent conjugation of PEG to therapeutic molecules. Protein PEGylation is a clinically proven approach for extending the circulation…”
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Molecular Modeling to Study Dendrimers for Biomedical Applications by Martinho, Nuno, Florindo, Helena, Silva, Liana, Brocchini, Steve, Zloh, Mire, Barata, Teresa

“…Molecular modeling techniques provide a powerful tool to study the properties of molecules and their interactions at the molecular level. The use of…”
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3D Printed Punctal Plugs for Controlled Ocular Drug Delivery by Xu, Xiaoyan, Awwad, Sahar, Diaz-Gomez, Luis, Alvarez-Lorenzo, Carmen, Brocchini, Steve, Gaisford, Simon, Goyanes, Alvaro, Basit, Abdul W

“…Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye…”
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Development of Targeted siRNA Nanocomplexes to Prevent Fibrosis in Experimental Glaucoma Filtration Surgery by Fernando, Owen, Tagalakis, Aristides D., Awwad, Sahar, Brocchini, Steve, Khaw, Peng T., Hart, Stephen L., Yu-Wai-Man, Cynthia

“…RNAi induced by double-stranded small interfering RNA (siRNA) molecules has attracted great attention as a naturally occurring approach to silence gene…”
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Comparative Binding of Disulfide-Bridged PEG-Fabs by Khalili, Hanieh, Godwin, Antony, Choi, Ji-won, Lever, Rebecca, Brocchini, Steve

“…Protein PEGylation is the most clinically validated method to improve the efficacy of protein-based medicines. Antibody fragments such as Fabs display rapid…”
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Translating Minimally Invasive Glaucoma Surgery Devices by Lee, Richard M.H., Bouremel, Yann, Eames, Ian, Brocchini, Steve, Khaw, Peng Tee

“…Glaucoma is the leading cause of irreversible blindness with over 70 million people affected worldwide. The surgical management of glaucoma aims to lower…”
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Novel approaches to model effects of subconjunctival blebs on flow pressure to improve clinical grading systems after glaucoma drainage surgery by Bouremel, Yann, Lee, Richard M H, Eames, Ian, Brocchini, Steve, Khaw, Peng Tee

“…Clinical grading systems following glaucoma filtration surgery do not include any effects of the bleb on the intra-ocular pressure and are relatively…”
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The Potential of Selenium-Based Therapies for Ocular Oxidative Stress by Al-Bassam, Lulwah, Shearman, Gemma C, Brocchini, Steve, Alany, Raid G, Williams, Gareth R

“…Oxidative stress plays a critical role in the development of chronic ocular conditions including cataracts, age-related macular degeneration, and diabetic…”
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Real-Time Monitoring Platform for Ocular Drug Delivery by Awwad, Sahar, Ibeanu, Nkiruka, Liu, Tianyang, Velentza-Almpani, Angeliki, Chouhan, Nerisha, Vlatakis, Stavros, Khaw, Peng Tee, Brocchini, Steve, Bouremel, Yann

“…Real-time measurement is important in modern dissolution testing to aid in parallel drug characterisation and quality control (QC). The development of a…”
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Injectables and Depots to Prolong Drug Action of Proteins and Peptides by Ibeanu, Nkiruka, Egbu, Raphael, Onyekuru, Lesley, Javaheri, Hoda, Khaw, Peng Tee, Williams, Gareth R, Brocchini, Steve, Awwad, Sahar

“…Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of…”
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Site-specific PEGylation of native disulfide bonds in therapeutic proteins by Shaunak, Sunil, Brocchini, Steve, Godwin, Antony, Choi, Ji-Won, Balan, Sibu, Pedone, Elisa, Vijayarangam, Damotharan, Heidelberger, Sibylle, Teo, Ian, Zloh, Mire

“…Native disulfide bonds in therapeutic proteins are crucial for tertiary structure and biological activity and are therefore considered unsuitable for chemical…”
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A New Reagent for Stable Thiol-Specific Conjugation by Badescu, George, Bryant, Penny, Swierkosz, Julia, Khayrzad, Farzad, Pawlisz, Estera, Farys, Monika, Cong, Yuehua, Muroni, Maurizio, Rumpf, Norbert, Brocchini, Steve, Godwin, Antony

“…Many clinically used protein therapeutics are modified to increase their efficacy. Example modifications include the conjugation of cytotoxic drugs to…”
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Effects of Flow Hydrodynamics and Eye Movements on Intraocular Drug Clearance by Velentza-Almpani, Angeliki, Ibeanu, Nkiruka, Liu, Tianyang, Redhead, Christopher, Tee Khaw, Peng, Brocchini, Steve, Awwad, Sahar, Bouremel, Yann

“…New in vitro prototypes (PK-Eye™) were tested with and without eye movement to understand diffusion and convection effects on intraocular clearance. Port…”
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Hydrodynamics of Intravitreal Injections into Liquid Vitreous Substitutes by Henein, Christin, Awwad, Sahar, Ibeanu, Nkiruka, Vlatakis, Stavros, Brocchini, Steve, Tee Khaw, Peng, Bouremel, Yann

“…Intravitreal injections have become the cornerstone of retinal care and one of the most commonly performed procedures across all medical specialties. The…”
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Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking by Conniot, João, Silva, Joana M, Fernandes, Joana G, Silva, Liana C, Gaspar, Rogério, Brocchini, Steve, Florindo, Helena F, Barata, Teresa S

“…Cancer is one of the most common diseases afflicting people globally. New therapeutic approaches are needed due to the complexity of cancer as a disease. Many…”
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Histidylated poly(lysine) dendrimers for siRNA delivery by Allahham, Nour, Buanz, Asma, Brocchini, Steve, Williams, Gareth R.

“…Since its discovery, small interfering RNA (siRNA) has revolutionised the field of gene silencing therapy because of its great potential in targeting diseases…”
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Computational and Experimental Evaluation of the Stability of a GLP-1-like Peptide in Ethanol–Water Mixtures by Lui, Lok Hin, Egbu, Raphael, Graver, Thomas, Williams, Gareth R., Brocchini, Steve, Velayudhan, Ajoy

“…Aggregation resulting from the self-association of peptide molecules remains a major challenge during preformulation. Whereas certain organic solvents are…”
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Stable Dried Catalase Particles Prepared by Electrospraying by Schlosser, Corinna S., Brocchini, Steve, Williams, Gareth R.

“…Therapeutic proteins and peptides are clinically important, offering potency while reducing the potential for off-target effects. Research interest in…”
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Maillard Reaction Crosslinked Alginate-Albumin Scaffolds for Enhanced Fenofibrate Delivery to the Retina: A Promising Strategy to Treat RPE-Related Dysfunction by Abedin Zadeh, Maria, Alany, Raid G, Satarian, Leila, Shavandi, Amin, Abdullah Almousa, Mohamed, Brocchini, Steve, Khoder, Mouhamad

“…There are limited treatments currently available for retinal diseases such as age-related macular degeneration (AMD). Cell-based therapy holds great promise in…”
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