Search Results - "Brocard, Jacques S."

Insights into the Mechanism of Action of Ferroquine. Relationship between Physicochemical Properties and Antiplasmodial Activity by Biot, Christophe, Taramelli, Donatella, Forfar-Bares, Isabelle, Maciejewski, Lucien A, Boyce, Mlandzeni, Nowogrocki, Guy, Brocard, Jacques S, Basilico, Nicoletta, Olliaro, Piero, Egan, Timothy J

“…Ferroquine (FQ) is a 4-aminoquinoline antimalarial which contains a quinoline nucleus similar to chloroquine, but a novel ferrocenic group in its side chain…”
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Synthesis and Antimalarial Activity in Vitro and in Vivo of a New Ferrocene−Chloroquine Analogue by Biot, Christophe, Glorian, Guillaume, Maciejewski, Lucien A, Brocard, Jacques S, Domarle, Olivier, Blampain, Georgette, Millet, Pascal, Georges, Alain J, Abessolo, Huguette, Dive, Daniel, Lebibi, Jacques

“…The antimalarial activities of ferrocenic compounds mimicking chloroquine and active upon chloroquine-resistant strains of Plasmodium falciparum were…”
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Synthesis of Ferroquine Enantiomers: First Investigation of Effects of Metallocenic Chirality upon Antimalarial Activity and Cytotoxicity by Delhaes, Laurence, Biot, Christophe, Berry, Laurence, Delcourt, Philippe, Maciejewski, Lucien A., Camus, Daniel, Brocard, Jacques S., Dive, Daniel

“…Ferroquine (FQ) is a new antimalarial agent with a high blood schizotoncidal activity. Previous studies on this compound were done with racemate mixtures. As…”
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Nanoscale Surface Topography Reshapes Neuronal Growth in Culture by Bugnicourt, Ghislain, Brocard, Jacques, Nicolas, Alice, Villard, Catherine

“…Neurons are sensitive to topographical cues provided either by in vivo or in vitro environments on the micrometric scale. We have explored the role of randomly…”
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Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse by Cacheux, Marine, Fauconnier, Jérémy, Thireau, Jérôme, Osseni, Alexis, Brocard, Jacques, Roux-Buisson, Nathalie, Brocard, Julie, Fauré, Julien, Lacampagne, Alain, Marty, Isabelle

“…Recessive forms of catecholaminergic polymorphic ventricular tachycardia (CPVT) are induced by mutations in genes encoding triadin or calsequestrin, two…”
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Motor-dependent microtubule disassembly driven by tubulin tyrosination by Peris, Leticia, Wagenbach, Michael, Lafanechère, Laurence, Brocard, Jacques, Moore, Ayana T, Kozielski, Frank, Job, Didier, Wordeman, Linda, Andrieux, Annie

“…In cells, stable microtubules (MTs) are covalently modified by a carboxypeptidase, which removes the C-terminal Tyr residue of α-tubulin. The significance of…”
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Triadin Deletion Induces Impaired Skeletal Muscle Function by Oddoux, Sarah, Brocard, Julie, Schweitzer, Annie, Szentesi, Peter, Giannesini, Benoit, Brocard, Jacques, Fauré, Julien, Pernet-Gallay, Karine, Bendahan, David, Lunardi, Joël, Csernoch, Laszlo, Marty, Isabelle

“…Triadin is a multiple proteins family, some isoforms being involved in muscle excitation-contraction coupling, and some having still unknown functions. To…”
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Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum by Baramee, Apiwat, Coppin, Alexandra, Mortuaire, Marlène, Pelinski, Lydie, Tomavo, Stanislas, Brocard, Jacques

“…Ferrocenyl atovaquone derivatives 1 and 2 were synthesized from the hydroxynaphthoquinone core and tested for their in vitro activity against Toxoplasma gondii…”
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Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction by Sébastien, Muriel, Giannesini, Benoit, Aubin, Perrine, Brocard, Julie, Chivet, Mathilde, Pietrangelo, Laura, Boncompagni, Simona, Bosc, Christophe, Brocard, Jacques, Rendu, John, Gory-Fauré, Sylvie, Andrieux, Annie, Fourest-Lieuvin, Anne, Fauré, Julien, Marty, Isabelle

“…The skeletal muscle fiber has a specific and precise intracellular organization which is at the basis of an efficient muscle contraction. Microtubules are long…”
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Probing the Role of the Covalent Linkage of Ferrocene into a Chloroquine Template by Biot, Christophe, Daher, Wassim, Ndiaye, Cheikh M, Melnyk, Patricia, Pradines, Bruno, Chavain, Natascha, Pellet, Alain, Fraisse, Laurent, Pelinski, Lydie, Jarry, Christian, Brocard, Jacques, Khalife, Jamal, Forfar-Bares, Isabelle, Dive, Daniel

“…A new therapeutic approach to malaria led to the discovery of ferroquine (FQ, SR97276). To assess the importance of the linkage of the ferrocenyl group to a…”
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Chronic administration of atypical antipsychotics improves behavioral and synaptic defects of STOP null mice by Delotterie, David, Ruiz, Geoffrey, Brocard, Jacques, Schweitzer, Annie, Roucard, Corinne, Roche, Yann, Suaud-Chagny, Marie-Françoise, Bressand, Karine, Andrieux, Annie

“…Introduction Recent studies have suggested that schizophrenia is associated with alterations in the synaptic connectivity involving cytoskeletal proteins. The…”
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Mutation of Ser172 in yeast β tubulin induces defects in microtubule dynamics and cell division by Caudron, Fabrice, Denarier, Eric, Thibout-Quintana, Jenny-Constanza, Brocard, Jacques, Andrieux, Annie, Fourest-Lieuvin, Anne

“…Ser172 of β tubulin is an important residue that is mutated in a human brain disease and phosphorylated by the cyclin-dependent kinase Cdk1 in mammalian cells…”
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Chiral ferrocenyl diphosphines for asymmetric transfer hydrogenation of acetophenone by Cabou, Jérôme, Brocard, Jacques, Pélinski, Lydie

“…[Display omitted] The synthesis of new optically pure ferrocenyl diphosphines have been realized from ( R)-(+)- N, N-dimethylaminoethylferrocene. Particularly,…”
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Synchrony of spontaneous calcium activity in mouse neocortex before synaptogenesis by Platel, Jean-Claude, Dupuis, Alain, Boisseau, Sylvie, Villaz, Michel, Albrieux, Mireille, Brocard, Jacques

“…Spontaneous calcium activity can be detected in embryonic mouse cortical slices as fluorescence intensity variations, in the presence of a fluorescent calcium…”
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Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure by Daher, Wassim, Biot, Christophe, Fandeur, Thierry, Jouin, Helene, Pelinski, Lydie, Viscogliosi, Eric, Fraisse, Laurent, Pradines, Bruno, Brocard, Jacques, Khalife, Jamal, Dive, Daniel

“…Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome…”
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Synthetic ferrocenic mefloquine and quinine analogues as potential antimalarial agents by BIOT, C, DELHAES, L, MACIEJEWSKI, L. A, MORTUAIRE, M, CAMUS, D, DIVE, D, BROCARD, J. S

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Na+Channel-Mediated Ca2+Entry Leads to Glutamate Secretion in Mouse Neocortical Preplate by J. -C. Platel, S. Boisseau, Dupuis, A., Brocard, J., A. Poupard, M. Savasta, M. Villaz, M. Albrieux

“…Before synaptogenesis, early excitability implicating voltage-dependent and transmitter-activated channels is known to be crucial for neuronal development. We…”
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Bioluminescent imaging of Ca2+ activity reveals spatiotemporal dynamics in glial networks of dark-adapted mouse retina by Agulhon, Cendra, Platel, Jean‐Claude, Kolomiets, Bogdan, Forster, Valérie, Picaud, Serge, Brocard, Jacques, Faure, Philippe, Brulet, Philippe

“…Glial Ca 2+ excitability plays a key role in reciprocal neuron–glia communication. In the retina, neuron–glia signalling is expected to be maximal in the…”
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Synthesis and antimycobacterial activity of ferrocenyl ethambutol analogues and ferrocenyl diamines by Razafimahefa, Dorothée, Ralambomanana, Dimby Andrianina, Hammouche, Lies, Pélinski, Lydie, Lauvagie, Sylvia, Bebear, Christiane, Brocard, Jacques, Maugein, Jeanne

“…The synthesis and initial in vitro evaluation of ferrocenyl diamino alcohols and diamines as a new class of antimycobacterial ethambutol analogues are…”
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Phosphorylation of microtubule-associated protein STOP by calmodulin kinase II: Phosphorylation of STOP by CaMKII by Baratier, Julie, Peris, Leticia, Brocard, Jacques S., Gory-Fauré, Sylvie, Dufour, Fabrice, Bosc, Christophe, Fourest-Lieuvin, Anne, Blanchoin, Laurent, Salin, Paul A., Job, Didier, Andrieux, Annie

“…STOP proteins are microtubule-associated, calmodulin-regulated proteins responsible for the high degree of stabilization displayed by neuronal microtubules…”
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