Search Results - "Broberg, Christopher A"

A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity by Walker, Kimberly A, Miner, Taryn A, Palacios, Michelle, Trzilova, Dominika, Frederick, Daniel R, Broberg, Christopher A, Sepúlveda, Victoria E, Quinn, Joshua D, Miller, Virginia L

“…The polysaccharide capsule is an essential virulence factor for in both community-acquired hypervirulent strains as well as health care-associated classical…”
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Type III Effector VopC Mediates Invasion for Vibrio Species by Zhang, Lingling, Krachler, Anne Marie, Broberg, Christopher A., Li, Yan, Mirzaei, Hamid, Gilpin, Christopher J., Orth, Kim

“…Vibrio spp. are associated with infections caused by contaminated food and water. A type III secretion system (T3SS2) is a shared feature of all clinical…”
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A nadA Mutation Confers Nicotinic Acid Auxotrophy in Pro-carcinogenic Intestinal Escherichia coli NC101 by Lopez, Lacey R., Barlogio, Cassandra J., Broberg, Christopher A., Wang, Jeremy, Arthur, Janelle C.

“…Inflammatory bowel diseases (IBDs) and inflammation-associated colorectal cancer (CRC) are linked to blooms of adherent-invasive Escherichia coli (AIEC) in the…”
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Impact of Nitric Oxide-Release Kinetics on Antifungal Activity by Grayton, Quincy E, Conlon, Ivie L, Broberg, Christopher A, Schoenfisch, Mark H

“…Pathogenic fungi are an increasing health threat due to the rise in drug resistance. The limited number of antifungals currently available and growing…”
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A consortia of clinical E. coli strains with distinct in vitro adherent/invasive properties establish their own co-colonization niche and shape the intestinal microbiota in inflammation-susceptible mice by Bleich, Rachel M, Li, Chuang, Sun, Shan, Ahn, Ju-Hyun, Dogan, Belgin, Barlogio, Cassandra J, Broberg, Christopher A, Franks, Adrienne R, Bulik-Sullivan, Emily, Carroll, Ian M, Simpson, Kenneth W, Fodor, Anthony A, Arthur, Janelle C

“…Inflammatory bowel disease (IBD) patients experience recurrent episodes of intestinal inflammation and often follow an unpredictable disease course. Mucosal…”
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Biofilm Dispersal, Reduced Viscoelasticity, and Antibiotic Sensitization via Nitric Oxide-Releasing Biopolymers by Grayton, Quincy E., Nguyen, Huan K., Broberg, Christopher A., Ocampo, Jeffrey, Nagy, Sarah G., Schoenfisch, Mark H.

“…Compared to planktonic bacteria, biofilms are notoriously difficult to eradicate due to their inherent protection against the immune response and antimicrobial…”
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Tipping the balance by manipulating post-translational modifications by Broberg, Christopher A, Orth, Kim

“…Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into…”
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Vibrio parahaemolyticus cell biology and pathogenicity determinants by Broberg, Christopher A., Calder, Thomas J., Orth, Kim

“…Vibrio parahaemolyticus is a significant cause of gastroenteritis worldwide. Characterization of this pathogen has revealed a unique repertoire of virulence…”
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AMPylation: Something Old is New Again by Woolery, Andrew R, Luong, Phi, Broberg, Christopher A, Orth, Kim

“…The post-translational modification AMPylation is emerging as a significant regulatory mechanism in both prokaryotic and eukaryotic biology. This process…”
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Shotgun proteomics of Xanthobacter autotrophicus Py2 reveals proteins specific to growth on propylene by Broberg, Christopher A, Clark, Daniel D

“…Coenzyme M (CoM, 2-mercaptoethanesulfonate), once thought to be exclusively produced by methanogens, is now known to be the central cofactor in the metabolism…”
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Klebsiella: a long way to go towards understanding this enigmatic jet-setter by Broberg, Christopher A, Palacios, Michelle, Miller, Virginia L

“…Klebsiella pneumoniae is the causative agent of a variety of diseases, including pneumonia, urinary tract infections, septicemia, and the recently recognized…”
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Sterilization effects on nitric oxide-releasing glucose sensors by Bradshaw, Taron M., Johnson, Courtney R., Broberg, Christopher A., Anderson, Darci E., Schoenfisch, Mark H.

“…Nitric oxide (NO) release from S-nitrosothiol-modified mesoporous silica nanoparticles imbedded in the diffusion limiting layer of a glucose sensor has been…”
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Impact of nitric oxide donors on capsule, biofilm and resistance profiles of Klebsiella pneumoniae by Nguyen, Huan K., Duke, Magdalena M., Grayton, Quincy E., Broberg, Christopher A., Schoenfisch, Mark H.

“…•Klebsiella pneumoniae can cause highly resistant infections, including biofilms.•Classical or hypervirulent strains possess different capsule…”
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Yersiniabactin-Producing Adherent/Invasive Escherichia coli Promotes Inflammation-Associated Fibrosis in Gnotobiotic Il10 -/- Mice by Ellermann, Melissa, Gharaibeh, Raad Z, Fulbright, Laura, Dogan, Belgin, Moore, Lyndsey N, Broberg, Christopher A, Lopez, Lacey R, Rothemich, Aaron M, Herzog, Jeremy W, Rogala, Allison, Gordon, Ilyssa O, Rieder, Florian, Brouwer, Cory R, Simpson, Kenneth W, Jobin, Christian, Sartor, R Balfour, Arthur, Janelle C

“…Fibrosis is a significant complication of intestinal disorders associated with microbial dysbiosis and pathobiont expansion, notably Crohn's disease (CD)…”
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Vibrio Effector Protein Is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity by Broberg, Christopher A, Zhang, Lingling, Gonzalez, Herman, Laskowski-Arce, Michelle A, Orth, Kim

“…The marine bacterium Vibrio parahaemolyticus causes gastroenteritis in humans and encodes the type III effector protein VPA0450, which contributes to host cell…”
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The “PepSAVI-MS” Pipeline for Natural Product Bioactive Peptide Discovery by Kirkpatrick, Christine L, Broberg, Christopher A, McCool, Elijah N, Lee, Woo Jean, Chao, Alex, McConnell, Evan W, Pritchard, David A, Hebert, Michael, Fleeman, Renee, Adams, Jessie, Jamil, Amer, Madera, Laurence, Strömstedt, Adam A, Göransson, Ulf, Liu, Yufeng, Hoskin, David W, Shaw, Lindsey N, Hicks, Leslie M

“…The recent increase in extensively drug-resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for…”
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Nitric Oxide-Induced Morphological Changes to Bacteria by Nguyen, Huan K., Picciotti, Samantha L., Duke, Magdalena M., Broberg, Christopher A., Schoenfisch, Mark H.

“…Antimicrobial resistance poses a serious threat to global health, necessitating research for alternative approaches to treating infections. Nitric oxide (NO)…”
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Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing by Maloney, Sara E., Broberg, Christopher A., Grayton, Quincy E., Picciotti, Samantha L., Hall, Hannah R., Wallet, Shannon M., Maile, Robert, Schoenfisch, Mark H.

“…Two glycosaminoglycan (GAG) biopolymers, hyaluronic acid (HA) and chondroitin sulfate (CS), were chemically modified via carbodiimide chemistry to facilitate…”
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A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae fepB Mutant by Palacios, Michelle, Broberg, Christopher A, Walker, Kimberly A, Miller, Virginia L

“…is considered a significant public health threat because of the emergence of multidrug-resistant strains and the challenge associated with treating…”
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Injectable Polysaccharide Hydrogels as Localized Nitric Oxide Delivery Formulations by Feura, Evan S., Maloney, Sara E., Conlon, Ivie L., Broberg, Christopher A., Yang, Feichen, Schoenfisch, Mark H.

“…A series of injectable polysaccharide hydrogels are prepared with oxidized dextran and diethylenetriamine‐modified carboxymethylcellulose (CMC) or hyaluronic…”
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