Search Results - "Broadus, Arthur E"

Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model by Macica, Carolyn, Liang, Guoying, Nasiri, Ali, Broadus, Arthur E.

“…Objective Parathyroid hormone–related protein (PTHrP) regulates the rate of differentiation of growth chondrocytes and is also expressed in articular…”
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PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth by Wang, Meina, VanHouten, Joshua N, Nasiri, Ali R, Johnson, Randy L, Broadus, Arthur E

“…The sites that receive ligament and tendon insertions (entheses) on the cortical surfaces of long bones are poorly understood, particularly regarding modeling…”
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Initial Characterization of PTH‐Related Protein Gene‐Driven lacZ Expression in the Mouse by Chen, Xuesong, Macica, Carolyn M, Dreyer, Barbara E, Hammond, Vicki E, Hens, Julie R, Philbrick, William M, Broadus, Arthur E

“…The PTHrP gene generates low‐abundance mRNA and protein products that are not easily localized by in situ hybridization histochemistry or immunohistochemistry…”
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Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing by Wang, Meina, Nasiri, Ali R, Broadus, Arthur E, Tommasini, Steven M

“…Abstract Parathyroid hormone-related protein (PTHrP) is widely expressed in the fibrous outer layer of the periosteum (PO), and the PTH/PTHrP type I receptor…”
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Parathyroid Hormone-Related Protein Induces Spontaneous Osteoclast Formation via a Paracrine Cascade by Nakchbandi, Inaam A., Weir, Eleanor E., Insogna, Karl L., Philbrick, William M., Broadus, Arthur E.

“…Experiments in vivo have established that tooth eruption fails in the absence of parathyroid hormone (PTH)-related protein (PTHrP) action in the…”
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Periosteal PTHrP regulates cortical bone modeling during linear growth in mice by Wang, Meina, VanHouten, Joshua N., Nasiri, Ali R., Tommasini, Steven M., Broadus, Arthur E.

“…The modeling of long bone surfaces during linear growth is a key developmental process, but its regulation is poorly understood. We report here that…”
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Mechanical regulation of PTHrP expression in entheses by Chen, Xuesong, Macica, Carolyn, Nasiri, Ali, Judex, Stefan, Broadus, Arthur E

“…Abstract The PTHrP gene is expressed in the periosteum and in tendon and ligament insertion sites in a PTHrP-lacZ knockin reporter mouse. Here, we present a…”
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The PTHrP Functional Domain Is at the Gates of Endochondral Bones by BROADUS, ARTHUR E., MACICA, CAROLYN, CHEN, XUESONG

“…:  PTHrP gene‐expression products are generally of very low abundance. The PTHrP‐lacZ knockin mouse is a useful tool in this regard, identifying PTHrP…”
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HYPERCALCEMIA OF MALIGNANCY: The Central Role of Parathyroid Hormone-Related Protein by Wysolmerski, John J, Broadus, Arthur E

“…Hypercalcemia is the most common metabolic complication of cancer. Malignancy-associated hypercalcemia (MAHC) can be divided into two syndromes, humoral…”
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The remarkable migration of the medial collateral ligament by Wang, Meina, Nasiri, Ali, VanHouten, Joshua N., Tommasini, Steven M., Broadus, Arthur E.

“…The developing cortical surfaces of long bones are sculpted and modeled by periosteal osteoclasts and osteoblasts. These surfaces also receive the insertions…”
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Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone–related protein in mice by Chen, Xuesong, Macica, Carolyn M., Nasiri, Ali, Broadus, Arthur E.

“…Objective Chondrocytes of the epiphyseal growth zone are regulated by the Indian hedgehog (IHH)–parathyroid hormone–related protein (PTHrP) axis. In…”
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Stretch‐Induced PTH‐Related Protein Gene Expression in Osteoblasts by Chen, Xuesong, Macica, Carolyn M, Ng, Kong Wah, Broadus, Arthur E

“…Mechanical forces play a critical role in regulating skeletal mass and structure. We report that mechanical loading induces PTHrP in osteoblast‐like cells and…”
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Induction of parathyroid hormone-related peptide following peripheral nerve injury: Role as a modulator of Schwann cell phenotype by Macica, Carolyn M., Liang, Guoying, Lankford, Karen L., Broadus, Arthur E.

“…Parathyroid hormone‐related peptide (PTHrP) is widely distributed in the rat nervous system, including the peripheral nervous system, where its function is…”
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Calcium homeostasis in immobilization: an example of resorptive hypercalciuria by Stewart, A F, Adler, M, Byers, C M, Segre, G V, Broadus, A E

“…Prolonged immobilization may result in hypercalcemia, hypercalciuria, and osteoporosis. Although bone resorption is central to this syndrome, the mechanism of…”
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Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development by Wysolmerski, J J, McCaughern-Carucci, J F, Daifotis, A G, Broadus, A E, Philbrick, W M

“…Parathyroid hormone-related protein (PTHrP) was originally discovered as the tumor product that causes humoral hypercalcemia of malignancy. PTHrP is now known…”
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The importance of circulating 1,25-dihydroxyvitamin D in the pathogenesis of hypercalciuria and renal-stone formation in primary hyperparathyroidism by Broadus, A E, Horst, R L, Lang, R, Littledike, E T, Rasmussen, H

“…Fifty patients with primary hyperparathyroidism were studied with an oral calcium-tolerance test, measurements of plasma levels of vitamin D metabolites, and…”
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PTHrP regulates cerebral blood flow and is neuroprotective by Macica, Carolyn M, Broadus, Arthur E

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Overexpression of Parathyroid Hormone-Related Protein in the Skin of Transgenic Mice Interferes with Hair Follicle Development by Wysolmerski, John J., Broadus, Arthur E., Zhou, Jing, Fuchs, Elaine, Milstone, Leonard M., Philbrick, William M.

“…Parathyroid hormone-related peptide (PTHrP) was initially discovered as the cause of the syndrome of humoral hypercalcemia of malignancy. Subsequently, the…”
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Immunochemical Characterization of Circulating Parathyroid Hormone–Related Protein in Patients with Humoral Hypercalcemia of Cancer by Burtis, William J, Brady, Thomas G, Orloff, John J, Ersbak, Julie B, Warrell, Raymond P, Olson, Beatriz R, Wu, Terence L, Mitnick, MaryAnn E, Broadus, Arthur E, Stewart, Andrew F

“…Tumors from patients with humoral hypercalcemia of cancer produce a parathyroid Hormone-Related protein (PTHRP). We have developed two region-specific…”
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Parathyroid hormone-related protein protects against kainic acid excitotoxicity in rat cerebellar granule cells by regulating L-type channel calcium flux by Brines, Michael L, Ling, Zhong, Broadus, Arthur E

“…The parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor genes are widely expressed in the CNS and both are highly expressed in the cerebellar…”
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