Search Results - "Broadley, KJ"

β-Adrenoceptor responses of the airways: For better or worse? by Broadley, Kenneth J.

“…β2-adrenoceptor agonists are the first-line treatment of asthma and chronic obstructive pulmonary disease (COPD), in which a short-acting β2-adrenoceptor…”
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Effect of vagotomy on airway hyperreactivity to endogenously released neurotransmitters at 18–24 h after inhaled antigen by Johnson, Alexia, Broadley, Kenneth J

“…Airway reactivity was examined in anaesthetized guinea-pigs 18–24 h after inhalation challenge of ovalbumin-sensitized animals with ovalbumin…”
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Khat: pharmacological and medical aspects and its social use in Yemen by Al-Motarreb, Ahmed, Baker, Kathryn, Broadley, Kenneth J

“…Fresh leaves of the khat tree (Catha edulis Forsk.) are chewed for their euphoric properties in East Africa and parts of the Middle East, such as The Yemen…”
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Vasoconstrictor and vasodilator responses to tryptamine of rat‐isolated perfused mesentery: comparison with tyramine and β‐phenylethylamine by Anwar, MA, Ford, WR, Broadley, KJ, Herbert, AA

“…BACKGROUND AND PURPOSE Tryptamine increases blood pressure by vasoconstriction, but little is known about its actions on the mesentery, in particular the…”
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Effect of Phosphodiesterase-5 Inhibitor, Sildenafil (Viagra), in Animal Models of Airways Disease by Toward, Toby J, Smith, Nicola, Broadley, Kenneth J

“…Phosphodiesterase (PDE)-5 degrades guanosine 3',5'cyclic monophosphate (cGMP) and its inhibitor sildenafil citrate (Viagra) treats erectile dysfunction by…”
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Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and [beta]-phenylethylamine by Anwar, MA, d, WR, Broadley, KJ, Herbert, AA

“…BACKGROUND AND PURPOSE Tryptamine increases blood pressure by vasoconstriction, but little is known about its actions on the mesentery, in particular the…”
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Khat chewing is a risk factor for acute myocardial infarction: a case‐control study by Al‐Motarreb, A., Briancon, S., Al‐Jaber, N., Al‐Adhi, B., Al‐Jailani, F., Salek, M S., Broadley, K J.

“…Aim Khat chewing is a common habit in Yemen and east African countries. Millions of people chew khat leaves daily for its euphoric and energetic effects and to…”
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Bronchoprotection in conscious guinea pigs by budesonide and the NO‐donating analogue, TPI 1020, alone and combined with tiotropium or formoterol by Turner, DL, Ferrari, N, Ford, WR, Kidd, EJ, Nevin, B, Paquet, L, Renzi, P, Broadley, KJ

“…BACKGROUND AND PURPOSE Inhaled corticosteroids, anticholinergics and β2‐adrenoceptor agonists are frequently combined for treating chronic respiratory…”
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Nitric oxide in respiratory diseases by Nevin, B.J, Broadley, K.J

“…The formation and modulation of nitric oxide (NO) in the lungs is reviewed. Its beneficial and deleterious roles in airways diseases, including asthma, chronic…”
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Early and late bronchoconstrictions, airway hyper-reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram by Toward, T. J., Broadley, K. J.

“…Summary Background Guinea‐pig models can provide the essential features of asthma, including early‐ (EAR) and late‐ (LAR) phase asthmatic responses, airway…”
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Khat chewing and acute myocardial infarction by Al-Motarreb, A, Al-Kebsi, M, Al-Adhi, B, Broadley, K J

“…PATIENTS AND METHODS One hundred and fifty seven patients of Arabian origin admitted to the intensive care unit of Al-Thawra hospital, Sanaa, Yemen with acute…”
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Muscarinic Receptor Agonists and Antagonists by Broadley, Kenneth J., Kelly, David R.

“…A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic…”
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Respiratory syncytial virus infections: characteristics and treatment by Chidgey, Sharon M., Broadley, Kenneth J.

“…In this review, we describe the history, epidemiology and clinical manifestations of infections attributed to respiratory syncytial virus (RSV) in children. At…”
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Goblet cell hyperplasia, airway function, and leukocyte infiltration after chronic lipopolysaccharide exposure in conscious Guinea pigs: effects of rolipram and dexamethasone by Toward, Toby J, Broadley, Kenneth J

“…The effects of chronic exposures (nine, 48 h apart) of conscious guinea pigs to lipopolysaccharide (LPS) (30 microg. ml(-1), 1 h) on airway function, airway…”
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Effects of hypoxia on the vasodilator activity of nifedipine and evidence of secondary pharmacological properties by Broadley, Kenneth J., Penson, Peter E.

“…The effects of hypoxia on the vasodilator response of endothelium-denuded rat aortic rings to the calcium channel blocker, nifedipine, were examined. Under…”
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A(3) receptors mediate rapid inflammatory cell influx into the lungs of sensitized guinea-pigs by Spruntulis, L M, Broadley, K J

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Chronic lipopolysaccharide exposure on airway function, cell infiltration, and nitric oxide generation in conscious guinea pigs: effect of rolipram and dexamethasone by Toward, T J, Broadley, K J

“…This study investigated whether a correlation between airway hyperreactivity (AHR), leukocyte influx, and nitric oxide (NO) existed in guinea pigs chronically…”
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Comparative effects of inhaled budesonide and the NO-donating budesonide derivative, NCX 1020, against leukocyte influx and airway hyperreactivity following lipopolysaccharide challenge by Nevin, Barra J, Broadley, Kenneth J

“…Lipopolysaccharide (LPS) inhalation (30 μg ml −1, 1 h) caused airway hypereactivity (AHR) to histamine (1 mM, 20 s) 1 h later in conscious guinea-pigs…”
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Airway reactivity, inflammatory cell influx and nitric oxide in guinea‐pig airways after lipopolysaccharide inhalation by Toward, Toby J, Broadley, Kenneth J

“…The aim of this study was to investigate the relationship between airway reactivity, leukocyte influx and nitric oxide (NO), in conscious guinea‐pigs after…”
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Airway function, oedema, cell infiltration and nitric oxide generation in conscious ozone‐exposed guinea‐pigs: effects of dexamethasone and rolipram by Toward, Toby J, Broadley, Kenneth J

“…The effects of ozone inhalation (90 min, 2.15±0.05 p.p.m.) and their modification by dexamethasone (20 mg kg−1) or the phosphodiesterase‐4 inhibitor, rolipram…”
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