Search Results - "Broadley, K J."

Vasoconstrictor and vasodilator responses to tryptamine of rat‐isolated perfused mesentery: comparison with tyramine and β‐phenylethylamine by Anwar, MA, Ford, WR, Broadley, KJ, Herbert, AA

“…BACKGROUND AND PURPOSE Tryptamine increases blood pressure by vasoconstriction, but little is known about its actions on the mesentery, in particular the…”
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Khat chewing is a risk factor for acute myocardial infarction: a case‐control study by Al‐Motarreb, A., Briancon, S., Al‐Jaber, N., Al‐Adhi, B., Al‐Jailani, F., Salek, M S., Broadley, K J.

“…Aim Khat chewing is a common habit in Yemen and east African countries. Millions of people chew khat leaves daily for its euphoric and energetic effects and to…”
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Dietary trace amine‐dependent vasoconstriction in porcine coronary artery by Herbert, A A, Kidd, E J, Broadley, K J

“…Background and purpose: The dietary trace amines tyramine and β‐phenylethylamine (β‐PEA) can increase blood pressure. However, the mechanisms involved in the…”
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Bronchoprotection in conscious guinea pigs by budesonide and the NO‐donating analogue, TPI 1020, alone and combined with tiotropium or formoterol by Turner, DL, Ferrari, N, Ford, WR, Kidd, EJ, Nevin, B, Paquet, L, Renzi, P, Broadley, KJ

“…BACKGROUND AND PURPOSE Inhaled corticosteroids, anticholinergics and β2‐adrenoceptor agonists are frequently combined for treating chronic respiratory…”
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Adenosine receptor subtypes in the airways responses to 5′-adenosine monophosphate inhalation of sensitized guinea-pigs by Smith, N., Broadley, K. J.

“…Summary Background Endogenous adenosine levels are raised in the lungs during asthma attacks. 5′‐adenosine monophosphate (5′‐AMP) inhalation in asthmatics…”
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Early and late bronchoconstrictions, airway hyper-reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram by Toward, T. J., Broadley, K. J.

“…Summary Background Guinea‐pig models can provide the essential features of asthma, including early‐ (EAR) and late‐ (LAR) phase asthmatic responses, airway…”
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Khat chewing and acute myocardial infarction by Al-Motarreb, A, Al-Kebsi, M, Al-Adhi, B, Broadley, K J

“…PATIENTS AND METHODS One hundred and fifty seven patients of Arabian origin admitted to the intensive care unit of Al-Thawra hospital, Sanaa, Yemen with acute…”
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Khat chewing, cardiovascular diseases and other internal medical problems: The current situation and directions for future research by Al-Motarreb, A., Al-Habori, M., Broadley, K.J.

“…The leaves of khat ( Catha edulis Forsk.) are chewed as a social habit for the central stimulant action of their cathinone content. This review summarizes the…”
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The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure by Schepelmann, M, Yarova, P L, Lopez-Fernandez, I, Davies, T S, Brennan, S C, Edwards, P J, Aggarwal, A, Graça, J, Rietdorf, K, Matchkov, V, Fenton, R A, Chang, W, Krssak, M, Stewart, A, Broadley, K J, Ward, D T, Price, S A, Edwards, D H, Kemp, P J, Riccardi, D

“…The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its role is not completely understood. In this study, we tested the…”
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Nitric oxide in respiratory diseases by Nevin, B.J, Broadley, K.J

“…The formation and modulation of nitric oxide (NO) in the lungs is reviewed. Its beneficial and deleterious roles in airways diseases, including asthma, chronic…”
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A3 receptors mediate rapid inflammatory cell influx into the lungs of sensitized guinea-pigs by Spruntulis, L. M., Broadley, K. J.

“…Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory cell activity. Elevated adenosine levels occur in the lungs…”
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LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma by Lowe, A P P, Thomas, R S, Nials, A T, Kidd, E J, Broadley, K J, Ford, W R

“…Background and Purpose Asthma exacerbations contribute to corticosteroid insensitivity. LPS is ubiquitous in the environment. It causes bronchoconstriction and…”
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Airway reactivity, inflammatory cell influx and nitric oxide in guinea‐pig airways after lipopolysaccharide inhalation by Toward, Toby J, Broadley, Kenneth J

“…The aim of this study was to investigate the relationship between airway reactivity, leukocyte influx and nitric oxide (NO), in conscious guinea‐pigs after…”
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PDE4 inhibition and a corticosteroid in chronically antigen exposed conscious guinea-pigs by DANAHAY, H, BROADLEY, K. J

“…Background The physiological and pharmacological consequences of repeated aero‐allergen challenge have not been previously characterized in conscious,…”
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Effects of inhibitors of phosphodiesterase, on antigen‐induced bronchial hyperreactivity in conscious sensitized guinea‐pigs and airway leukocyte infiltration by Danahay, Henry, Broadley, Kenneth J

“…The aim of this study was to determine the effects of inhibitors of phosphodiesterase (PDE) on the early and late phase bronchoconstriction in sensitized,…”
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Influences, decisions and serendipity: an autobiography by Broadley, K J

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Effect of vagotomy on airway hyperreactivity to endogenously released neurotransmitters at 18–24 h after inhaled antigen by Johnson, Alexia, Broadley, Kenneth J

“…Airway reactivity was examined in anaesthetized guinea-pigs 18–24 h after inhalation challenge of ovalbumin-sensitized animals with ovalbumin…”
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Analysis of the bronchoconstrictor responses to adenosine receptor agonists in sensitized guinea-pig lungs and trachea by Thorne, Julian R., Danahay, Henry, J. Broadley, Kenneth

“…Airway perfused lungs and half-lungs and superfused tracheal spirals from ovalbumin-sensitized guinea pigs were set up. Adenosine and the analogues, 5′-(…”
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Airway hyper‐ or hyporeactivity to inhaled spasmogens 24 h after ovalbumin challenge of sensitized guinea‐pigs by Lewis, Christine A., Broadley, Kenneth J.

“…1 The aim of this study was to determine whether an inhalation of ovalbumin (OA, 10 or 20 mg ml−1) by conscious OA‐sensitized guinea‐pigs leads to airway…”
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Analysis of the atypical characteristics of adenosine receptors mediating negative inotropic and chronotropic responses of guinea‐pig isolated atria and papillary muscles by Gardner, Neil M, Broadley, Kenneth J

“…Adenosine receptor(s) mediating negative inotropy of paced left atria, isoprenaline‐stimulated paced left atria and papillary muscles, and negative chronotropy…”
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