Search Results - "Broadhurst, Michael"

The parabolised stability equations for 3D-flows: implementation and numerical stability by Broadhurst, Michael S., Sherwin, Spencer J.

“…The numerical implementation of the parabolised stability equations (PSE) using a spectral/ hp-element discretisation is considered, and the numerical…”
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Concise Syntheses of γ-Oxo-β,β-difluorinated Amino Acids via Chelated [3,3]-Rearrangement of Difluoroallylic Alcohols by Percy, Jonathan M, Prime, Michael E, Broadhurst, Michael J

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Rearrangement of unactivated N-alkyl- O-benzoyl hydroxamic acid derivatives with phosphazene bases by Clark, Andrew J, Al-Faiyz, Yassair S.S, Patel, Divya, Broadhurst, Michael J

“…The phosphazene super bases BTPP 5 , P-2- t Bu 6 , and P-4- t Bu 7 mediate the rearrangement of unactivated N-alkyl- O-benzoyl hydroxamic acid derivatives 8 ,…”
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Cyclisation of Aminyl Radicals Derived from Amino Acids by Bowman, W.Russell, Broadhurst, Michael J, Coghlan, Daniel R, Lewis, Kirk A

“…α-Amino acid aminyl radicals have been generated from sulfenamide precursors using Bu3SnH. The aminyl radicals undergo 5-exo-trig cyclisation reactions onto…”
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Base-mediated reactions of N-alkyl- O-acyl hydroxamic acids: synthesis of 3-oxo-2,3-dihydro-4-isoxazole carboxylic ester derivatives by Clark, Andrew J., Patel, Divya, Broadhurst, Michael J.

“…Treatment of malonyl derived O-acyl hydroxamic acid derivatives 10a– h with the phosphazene super base P-2- t-Bu 7 gives 2,3-dihydro-4-isoxazole carboxylic…”
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A novel intramolecular ester-enolate alkylation: preparation of acyl ketene acetals by Broadhurst, Michael D

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Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitors by Bottomley, K M, Borkakoti, N, Bradshaw, D, Brown, P A, Broadhurst, M J, Budd, J M, Elliott, L, Eyers, P, Hallam, T J, Handa, B K, Hill, C H, James, M, Lahm, H W, Lawton, G, Merritt, J E, Nixon, J S, Röthlisberger, U, Whittle, A, Johnson, W H

“…N-terminal analysis of aggrecan fragments lost from bovine nasal cartilage cultured in the presence of recombinant human interleukin 1alpha revealed a…”
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Synthesis and antitumor activity of 9-[(carbamoyloxy)alkyl]anthracyclines a novel class of anthracycline derivatives by Adams, Nigel, Blake, Colin, Broadhurst, Michael J, Bushnell, David J, Hassall, Cedric H, Hartmann, Hans R, Keech, Elizabeth, Stratton, Alan R, Thomas, Gareth J

“…A number of 4-demethoxyanthracyclines having hydroxylalkyl functions at the 9-position have previously been synthesized and shown to have potent antitumor…”
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Synthesis and antitumor activity of novel 4-demethoxyanthracyclines by Adams, Nigel, Blake, Colin, Broadhurst, Michael J, Bushnell, David J, Hassall, Cedric H, Hartmann, Hans R, Keech, Elizabeth, Stratton, Alan R, Thomas, Gareth J

“…A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl,…”
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Electrophilic substitution at saturated carbon. 52. A model for the proton transfer steps of biological transamination and the effect of a 4-pyridyl group on the base-catalyzed racemization of a carbon acid by Jaeger, David A, Broadhurst, Michael D, Cram, Donald J

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Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening by Pickett, Stephen D, Sherborne, Bradley S, Wilkinson, Trevor, Bennett, James, Borkakoti, Neera, Broadhurst, Michael, Hurst, David, Kilford, Ian, McKinnell, Murray, Jones, Philip S

“…Novel, low molecular weight inhibitors of IMPDH have been discovered through the application of a validated virtual screening protocol. A series of 21 IMPDH…”
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Addition reactions of the uniparticulate electrophile chlorosulfonyl isocyanate to highly strained bicyclic hydrocarbons by Paquette, Leo A, Allen, George R, Broadhurst, Michael J

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Needs analysis in a corporate setting by Broadhurst, Michael

“…This project draws from materials related to Human Performance Technology. It looks at individual roles as well as corporate dynamics in assessing performance…”
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Unsaturated heterocyclic systems. XCI. Stereochemical and substituent effects in chlorosulfonyl isocyanate additions to cis-bicyclo[6.1.0] nonatrienes by Paquette, Leo A, Broadhurst, Michael J, Lee, Cheeman, Clardy, Jon

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Unsaturated heterocyclic systems. LXXXIX. Reactivity of bicyclo [4.2.2] deca-2,4,7,9-tetraene derivatives under conditions of uniparticulate electrophilic addition. Intramolecular capture of zwitterionic bridged 1,4-bishomotropylium (bicyclo [4.3.1] deca-2,4,7-trienyl) intermediates by Paquette, Leo A, Broadhurst, Michael J

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Unsaturated heterocyclic systems. XC. Uniparticulate electrophilic addition as a probe of possible bicycloaromatic and antibicycloaromatic carbonium ion character. Reactions of chlorosulfonyl isocyanate with exocyclic methylene precursors to such cations by Paquette, Leo A, Broadhurst, Michael J

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Unsaturated heterocyclic systems. LXXXVII. Substituent effects on the nonconcerted cycloaddition of chlorosulfonyl isocyanate to cis-bicyclo[6.1.0.]nonatriene derivatives by Paquette, Leo A, Broadhurst, Michael J

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Model for the proton transfer stages of the biological transaminations and isotopic exchange reactions of amino acids by Broadhurst, Michael D, Cram, Donald J

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Unsaturated heterocyclic systems. LXXXVI. Stereochemistry of uniparticulate electrophilic additions to cis-bicyclo[6.1.0.]nonatrienes by Paquette, Leo A, Broadhurst, Michael J, Lee, Chee-Man, Clardy, Jon

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Vortex Stability and Breakdown : Direct Numerical Simulation and Stability Analysis Using BiGlobal and Parabolised Formulations by Broadhurst, Michael Stuart

“…This thesis concerns the application and implementation of recently developed stability techniques to the understanding of vortex stability and breakdown. The…”
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