Search Results - "Broadbent, Steven"

Addressing the Need for Clinical Trial End Points in Autosomal Dominant Polycystic Kidney Disease: A Report From the Polycystic Kidney Disease Outcomes Consortium (PKDOC) by Smith, Kimberly A., Thompson, Aliza M., Baron, David A., Broadbent, Steven T., Lundstrom, Gary H., Perrone, Ronald D.

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Expansion of multiple cysts throughout both kidneys is…”
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Interaction between 2 extracellular loops influences the activity of the cystic fibrosis transmembrane conductance regulator chloride channel by Broadbent, Steven D, Wang, Wuyang, Linsdell, Paul

“…Activity of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is thought to be controlled by cytoplasmic factors. However, recent…”
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The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor by Broadbent, Steven D., Ramjeesingh, Mohabir, Bear, Christine E., Argent, Barry E., Linsdell, Paul, Gray, Michael A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl − channel that governs the quantity and composition of epithelial secretions. CFTR…”
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Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells by Krashia, Paraskevi, Moroni, Mirko, Broadbent, Steven, Hofmann, Giovanna, Kracun, Sebastian, Beato, Marco, Groot-Kormelink, Paul J, Sivilotti, Lucia G

“…The neuronal nicotinic receptors that mediate excitatory transmission in autonomic ganglia are thought to be formed mainly by the α3 and β4 subunits…”
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Constraining the expression of nicotinic acetylcholine receptors by using pentameric constructs by Groot-Kormelink, Paul J, Broadbent, Steven, Beato, Marco, Sivilotti, Lucia G

“…Much of our understanding of ligand-gated ion channels comes from heterologous expression studies. However, this technique cannot produce receptors with a…”
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Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors by Groot-Kormelink, Paul J, Broadbent, Steven D, Boorman, James P, Sivilotti, Lucia G

“…Tandem constructs are increasingly being used to restrict the composition of recombinant multimeric channels. It is therefore important to assess not only…”
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Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development by Lickiss, Bettina, Hunker, Jan, Bhagwan, Jamie, Linder, Peter, Thomas, Ulrich, Lotay, Hardeep, Broadbent, Steven, Dragicevic, Elena, Stoelzle-Feix, Sonja, Turner, Jan, Gossmann, Matthias

“…Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) have found utility for conducting in vitro drug screening and disease modelling to…”
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Human alpha 3 beta 4 Neuronal Nicotinic Receptors Show Different Stoichiometry if They Are Expressed in Xenopus Oocytes or Mammalian HEK293 Cells by Krashia, Paraskevi, Moroni, Mirko, Broadbent, Steven, Hofmann, Giovanna, Kracun, Sebastian, Beato, Marco, Groot-Kormelink, Paul J, Sivilotti, Lucia G

“…The neuronal nicotinic receptors that mediate excitatory transmission in autonomic ganglia are thought to be formed mainly by the alpha 3 and beta 4 subunits…”
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Activation of IP 3 R in atrial cardiomyocytes leads to generation of cytosolic cAMP by Akerman, Emily C, Read, Matthew J, Bose, Samuel J, Koschinski, Andreas, Capel, Rebecca A, Chao, Ying-Chi, Folkmanaite, Milda, Ayagama, Thamali, Broadbent, Steven D, Ahamed, Rufaida, Simon, Jillian N, Terrar, Derek A, Zaccolo, Manuela, Burton, Rebecca A B

“…Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Excessive stimulation of the inositol (1,4,5)-trisphosphate (IP ) signaling pathway…”
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Human [alpha]3[beta]4 Neuronal Nicotinic Receptors Show Different Stoichiometry if They Are Expressed in Xenopus Oocytes or Mammalian HEK293 Cells by Krashia, Paraskevi, Moroni, Mirko, Broadbent, Steven, Hofmann, Giovanna, Kracun, Sebastian, Beato, Marco, Groot-Kormelink, Paul J, Sivilotti, Lucia G

“…Background The neuronal nicotinic receptors that mediate excitatory transmission in autonomic ganglia are thought to be formed mainly by the [alpha]3 and…”
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The Effects of β3 Subunit Incorporation on the Pharmacology and Single Channel Properties of Oocyte-expressed Human α3β4 Neuronal Nicotinic Receptors by Boorman, James P., Beato, Marco, Groot-Kormelink, Paul J., Broadbent, Steven D., Sivilotti, Lucia G.

“…We compared the main properties of human recombinant α3β4β3 neuronal nicotinic receptors with those of α3β4 receptors, expressed in Xenopus oocytes. β3…”
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Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with α-lipoic acid and evening primrose oil by Shotton, Hannah R, Broadbent, Steven, Lincoln, Jill

“…Treatment with α-lipoic acid (LA) or evening primrose oil (EPO), individually, fails to prevent diabetes-induced changes in enteric nerves. Since synergy…”
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Incorporation of the beta3 subunit has a dominant-negative effect on the function of recombinant central-type neuronal nicotinic receptors by Broadbent, Steven, Groot-Kormelink, Paul J, Krashia, Paraskevi A, Harkness, Patricia C, Millar, Neil S, Beato, Marco, Sivilotti, Lucia G

“…The beta3 neuronal nicotinic subunit is localized in dopaminergic areas of the central nervous system, in which many other neuronal nicotinic subunits are…”
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The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors by Boorman, James P, Beato, Marco, Groot-Kormelink, Paul J, Broadbent, Steven D, Sivilotti, Lucia G

“…We compared the main properties of human recombinant alpha3beta4beta3 neuronal nicotinic receptors with those of alpha3beta4 receptors, expressed in Xenopus…”
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An investigation into neuronal nicotinic receptors with complex compositions by Broadbent, Steven David

“…Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels of the nicotinic superfamily. They are found widely in the autonomic nervous…”
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The Effects of β3 Subunit Incorporation on the Pharmacology and Single Channel Properties of Oocyte-expressed Human α3β4 Neuronal Nicotinic Receptors by James P. Boorman, Marco Beato, Paul J. Groot-Kormelink, Steven D. Broadbent, Lucia G. Sivilotti

“…We compared the main properties of human recombinant α3β4β3 neuronal nicotinic receptors with those of α3β4 receptors, expressed in Xenopus oocytes. β3…”
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