Search Results - "Broadbent, David G"

Systematic analysis of the molecular and biophysical properties of key DNA damage response factors by Heyza, Joshua R, Mikhova, Mariia, Bahl, Aastha, Broadbent, David G, Schmidt, Jens C

“…Repair of DNA double strand breaks (DSBs) is integral to preserving genomic integrity. Therefore, defining the mechanisms underlying DSB repair will enhance…”
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Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation by Broadbent, David G, Barnaba, Carlo, Perez, Gloria I, Schmidt, Jens C

“…Autophagy is a catabolic pathway required for the recycling of cytoplasmic materials. To define the mechanisms underlying autophagy it is critical to…”
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AMPK regulates phagophore-to-autophagosome maturation by Barnaba, Carlo, Broadbent, David G, Kaminsky, Emily G, Perez, Gloria I, Schmidt, Jens C

“…Autophagy is an important metabolic pathway that can non-selectively recycle cellular material or lead to targeted degradation of protein aggregates or damaged…”
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Metabolic-Stress-Induced Rearrangement of the 14-3-3ζ Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3ζ Interaction with Phosphorylated Atg9 by Weerasekara, Vajira K., Panek, David J., Broadbent, David G., Mortenson, Jeffrey B., Mathis, Andrew D., Logan, Gideon N., Prince, John T., Thomson, David M., Thompson, J. Will, Andersen, Joshua L.

“…14-3-3ζ promotes cell survival via dynamic interactions with a vast network of binding partners, many of which are involved in stress regulation. We show here…”
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ATG9A‐mediated turnover of p62 condensates requires ubiquitin and occurs independently of the LC3‐lipidation machinery by McEwan, Colten M., Broadbent, David G., Poole, Daniel M., Naylor, Brad C., Price, John C., Schmidt, Jens C., Andersen, Josh L.

“…Autophagy is a tightly controlled cellular recycling process that requires a host of autophagy machinery to form a double membraned vesicle called the…”
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Abstract 1942: Quantitative D2O proteomics reveals ATG9A-dependent autophagy substrates that are degraded independently of the LC3-lipidation machinery by McEwan, Colten M., Broadbent, David G., Kannangara, Ashari R., Poole, Daniel M., Naylor, Bradley C., Price, John C., Schmidt, Jens C., Andersen, Josh L.

“…Autophagy is an essential catabolic process that cancer cells use to survive metabolic stress and maintain basal cellular homeostasis via degradation of…”
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