Circulating angiotensin-(1-7) is decreased in patients with isolated nocturnal hypertension

Circulating angiotensin-(1-7) is decreased in patients with isolated nocturnal hypertension

Isolated nocturnal hypertension (INHT), defined as nighttime elevated blood pressure (BP) with normal daytime BP assessed by ambulatory BP monitoring, is associated with higher cardiovascular morbidity and mortality. We hypothesized that an alteration in the circulating renin-angiotensin system (RAS...

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Bibliographic Details
Published in:Journal of hypertension Vol. 42; no. 6; pp. 1101 - 1104
Main Authors: Minetto, Julián, Cuello, María B, Dominici, Fernando P, Caniffi, Carolina, Brizzio, Ana M, Cerri, Gustavo, Salazar, Martin R, Espeche, Walter G, Gironacci, Mariela M
Format: Journal Article
Language:English
Published: Netherlands 01-06-2024
Subjects:
Adult
Angiotensin I - blood
Angiotensin II - blood
Angiotensin-Converting Enzyme 2 - blood
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm
Female
Humans
Hypertension - blood
Hypertension - physiopathology
Male
Middle Aged
Peptide Fragments - blood
Peptidyl-Dipeptidase A - blood
Renin-Angiotensin System - physiology
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Summary:Isolated nocturnal hypertension (INHT), defined as nighttime elevated blood pressure (BP) with normal daytime BP assessed by ambulatory BP monitoring, is associated with higher cardiovascular morbidity and mortality. We hypothesized that an alteration in the circulating renin-angiotensin system (RAS) contributes to INHT development. We examined circulating levels of angiotensin (Ang) (1-7) and Ang II and ACE2 activity in 26 patients that met the INHT criteria, out of 50 that were referred for BP evaluation (62% women, 45 ± 16 years old). Those with INHT were older, had a higher BMI, lower circulating Ang-(1-7) (P = 0.002) and Ang II levels (P = 0.02) and no change in ACE2 activity compared to those normotensives. Nighttime DBP was significantly correlated with Ang-(1-7) and Ang II levels. Logistic regression showed significant association in Ang-(1-7) and Ang II levels with INHT. Our study reveals differences in circulating RAS in individuals with INHT.
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ISSN:0263-6352
1473-5598
DOI:10.1097/HJH.0000000000003728