Search Results - "Brix, Lea M."

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice by Häusl, Alexander S., Brix, Lea M., Hartmann, Jakob, Pöhlmann, Max L., Lopez, Juan-Pablo, Menegaz, Danusa, Brivio, Elena, Engelhardt, Clara, Roeh, Simone, Bajaj, Thomas, Rudolph, Lisa, Stoffel, Rainer, Hafner, Kathrin, Goss, Hannah M., Reul, Johannes M. H. M., Deussing, Jan M., Eder, Matthias, Ressler, Kerry J., Gassen, Nils C., Chen, Alon, Schmidt, Mathias V.

“…Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-adrenal (HPA) axis is a fundamental component of multiple…”
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Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice by Brix, Lea M., Toksöz, Irmak, Aman, London, Kovarova, Veronika, Springer, Margherita, Bordes, Joeri, van Doeselaar, Lotte, Engelhardt, Clara, Häusl, Alexander S., Narayan, Sowmya, Sterlemann, Vera, Yang, Huanqing, Deussing, Jan M., Schmidt, Mathias V.

“…Steroidogenic factor 1 (SF1) expressing neurons in the ventromedial hypothalamus (VMH) have been directly implicated in whole-body metabolism and in the onset…”
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Metabolic effects of early life stress and pre‐pregnancy obesity are long lasting and sex specific in mice by Brix, Lea M., Monleon, Daniel, Collado, Maria Carmen, Ederveen, Thomas H. A., Toksöz, Irmak, Bordes, Joeri, Doeselaar, Lotte, Engelhardt, Clara, Mitra, Shiladitya, Narayan, Sowmya, Schmidt, Mathias V.

“…Early life stress (ELS) is associated with metabolic, cognitive, and psychiatric diseases and has a very high prevalence, highlighting the urgent need for a…”
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Sex-specific and opposed effects of FKBP51 in glutamatergic and GABAergic neurons: Implications for stress susceptibility and resilience by van Doeselaar, Lotte, Stark, Tibor, Mitra, Shiladitya, Yang, Huanqing, Bordes, Joeri, Stolwijk, Linda, Engelhardt, Clara, Kovarova, Veronika, Narayan, Sowmya, Brix, Lea M, Springer, Margherita, Deussing, Jan M, Lopez, Juan Pablo, Czisch, Michael, Schmidt, Mathias V

“…Mental health disorders often arise as a combination of environmental and genetic factors. The gene, encoding the GR co-chaperone FKBP51, has been uncovered as…”
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The co-chaperone FKBP51 modulates HPA axis activity and age-related maladaptation of the stress system in pituitary proopiomelanocortin cells by Brix, Lea M., Häusl, Alexander S., Toksöz, Irmak, Bordes, Joeri, van Doeselaar, Lotte, Engelhardt, Clara, Narayan, Sowmya, Springer, Margherita, Sterlemann, Vera, Deussing, Jan M., Chen, Alon, Schmidt, Mathias V.

“…Glucocorticoid (GC)-mediated negative feedback of the hypothalamic-pituitary-adrenal (HPA) axis, the body’s physiological stress response system, is tightly…”
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Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism by Häusl, Alexander S, Bajaj, Thomas, Brix, Lea M, Pöhlmann, Max L, Hafner, Kathrin, De Angelis, Meri, Nagler, Joachim, Dethloff, Frederik, Balsevich, Georgia, Schramm, Karl-Werner, Giavalisco, Patrick, Chen, Alon, Schmidt, Mathias V, Gassen, Nils C

“…The mediobasal hypothalamus (MBH) is the central region in the physiological response to metabolic stress. The FK506-binding protein 51 (FKBP51) is a major…”
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